Author Topic: Russian Poiscenter  (Read 31041 times)

demografx

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Re: Russian Poiscenter
« Reply #40 on: July 01, 2020, 08:28:55 PM »

Thanks for the information Shep!


Thanks for posting, Limejuice!

Sending your kind words to Shep by email.
« Last Edit: July 01, 2020, 09:56:54 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: Russian Poiscenter
« Reply #41 on: July 02, 2020, 07:22:58 AM »

Hi Demo! I was waiting for a response from one user of the Russian site, and he answered me.
I would like to ask you to read this theory, and if there is an opportunity to correct it and pass it to the POIS researchers. Publish a post on your site if you want. Thanks! Let me know! Sorry for the English!

"We have a genetic failure of one of the SERT serotonin transporters. There are about 50 of them known, and each is responsible for the capture of serotonin in the synaptic clefts of different parts of the central nervous system. Our case is serotonin from the pineal gland to the hypothalamus, which extinguishes excess sexuality. And since the reverse capture does not works, then serotonin seems to be in short supply, and this gives our hypersexuality (I want sex even when the body does not pull).
Since the hypothalamus regulates stress and endocrinology, it increases serotonin from the pineal gland, but serotonin synthesis is increased everywhere by the side. And this gives the types of POIS. Depending on the characteristics of the exchanges, there are 2 extreme conditions. One thing is when serotonin is always everywhere low, and there are more symptoms with the psyche - insecurity, sociophobia, panic attacks, and great hypersexuality that simply squeezes the body. The second extreme, when the body managed to raise serotonin and muffle mental problems, but then all the inflammations, problems with the gastrointestinal tract and liver, and fog in the head come out.The fog in the head is precisely in this part, since it is from edema of the head, and edema from excessive serotonin in platelets. Well, all the changes are somewhere between these extreme positions. Here is the second case, German very well understood, and if this is your case, then German helps such people. And the pure first case is experiments with tranquilizers and SSRIs, but there will be no breakthrough until SSRIs invent exactly for serotonin in the pineal gland.


Fascinating theory!

Hopeoneday

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« Last Edit: July 02, 2020, 09:22:16 AM by Hopeoneday »
Dr-pois.

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Russian Poiscenter
« Reply #44 on: July 02, 2020, 11:22:08 AM »

Hi Demo! I was waiting for a response from one user of the Russian site, and he answered me.
I would like to ask you to read this theory, and if there is an opportunity to correct it and pass it to the POIS researchers. Publish a post on your site if you want. Thanks! Let me know! Sorry for the English!

"We have a genetic failure of one of the SERT serotonin transporters. There are about 50 of them known, and each is responsible for the capture of serotonin in the synaptic clefts of different parts of the central nervous system. Our case is serotonin from the pineal gland to the hypothalamus, which extinguishes excess sexuality. And since the reverse capture does not works, then serotonin seems to be in short supply, and this gives our hypersexuality (I want sex even when the body does not pull).
Since the hypothalamus regulates stress and endocrinology, it increases serotonin from the pineal gland, but serotonin synthesis is increased everywhere by the side. And this gives the types of POIS. Depending on the characteristics of the exchanges, there are 2 extreme conditions. One thing is when serotonin is always everywhere low, and there are more symptoms with the psyche - insecurity, sociophobia, panic attacks, and great hypersexuality that simply squeezes the body. The second extreme, when the body managed to raise serotonin and muffle mental problems, but then all the inflammations, problems with the gastrointestinal tract and liver, and fog in the head come out.The fog in the head is precisely in this part, since it is from edema of the head, and edema from excessive serotonin in platelets. Well, all the changes are somewhere between these extreme positions. Here is the second case, German very well understood, and if this is your case, then German helps such people. And the pure first case is experiments with tranquilizers and SSRIs, but there will be no breakthrough until SSRIs invent exactly for serotonin in the pineal gland.


Fascinating theory!

Emailed to Shep.

Thank you, Nas
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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« Last Edit: July 02, 2020, 11:44:49 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Shep

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Re: Russian Poiscenter
« Reply #47 on: July 02, 2020, 12:53:56 PM »
Hi. We are very glad that you were interested in the theory of slon_ik and you do not pass by. You have more people on the site, maybe someone will continue this in the direction of physical embodiment. I especially wanted to know the opinion of the user nicknamed
nanna1 Thank you! ;)
« Last Edit: July 02, 2020, 03:06:03 PM by demografx »

demografx

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Re: Russian Poiscenter
« Reply #48 on: July 02, 2020, 02:48:06 PM »
Thank you, Shep!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

berlin1984

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Re: Russian Poiscenter
« Reply #49 on: July 02, 2020, 02:56:49 PM »
Thanks for the FW Demo. Some of these parameters can be measured in Berlin if anyone is interested:
https://poiscenter.com/forums/index.php?topic=3207.0

See Serotonin (platelets)/Tryptophan metabolism 391-395:
https://www.imd-berlin.de/fileadmin/user_upload/Anforderungsscheine/SI_Anforderung_IGEL.pdf

OK, I'm in Berlin.

Which of those 391-395 shall I measure
At which state (neutral or in POIS? When?)
What do we expect to get as result to confirm a theory?

I'm not really understanding yet..Is it about excess Tryptophan?

"Here is the second case, German very well understood, and if this is your case, then German helps such people."

What does this mean? :-)

demografx

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Re: Russian Poiscenter
« Reply #50 on: July 02, 2020, 03:04:09 PM »

"Here is the second case, German very well understood, and if this is your case, then German helps such people."

What does this mean? :-)

You had “demografx” as the author because I was quoting Shep. So I  changed it to slon_ik (Russian forum member).

Emailing above to Shep :)
« Last Edit: July 02, 2020, 03:17:38 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

berlin1984

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Re: Russian Poiscenter
« Reply #51 on: July 02, 2020, 04:16:11 PM »
Quote from: slon_ik
And from platelets, serotonin comes out under stress, for example during ejaculation.

How would this link to https://www.pnas.org/content/115/7/E1550 ?
I'm not a biologist, see the Fig. 6 in the study.
Maybe the orgasm indirectly releases serotonine which then somehow makes the ICs "break" and re-release the pathogens (because they're not bound with the antigen anymore) (?).
Then this would explain my sore throat / weak immune system after orgasm?
(And would explain Transiently Induced Immune Deficiency, the pathogens are free-flowing after the orgasm)

slon_ik, nanna1, I have no scientific knowledge, please tell me if what I write is bogus then I'll strike it out.

demografx

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Re: Russian Poiscenter
« Reply #52 on: July 02, 2020, 05:50:41 PM »
berlin1984, thanks, emailing your post to Shep!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

drop247

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Re: Russian Poiscenter
« Reply #53 on: July 03, 2020, 12:51:36 PM »
How does the success many have had with anti-histamines fit with this theory? Do they effect serotonin directly or indirectly?

slon_ik

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Re: Russian Poiscenter
« Reply #54 on: July 12, 2020, 11:07:31 AM »
How does the success many have had with anti-histamines fit with this theory? Do they effect serotonin directly or indirectly?

Гистамин, серотонин  и простагландины это основные воспалительные агенты. Если уменьшить гистамин, то для серотонина как бы освобождается место. И тогда воспаление POIS начнется уже при большей дозе серотонина. То есть можно уменьшать гистамин или серотонин или пить НПВС, и эффект будет одинаковый. Но у всех разные пропорции воспалительных агентов, поэтому всем помогают разные препараты.


Histamine, serotonin and prostaglandins are the main inflammatory agents. If histamine is reduced, then for serotonin a place is freed up, as it were. And then the inflammation of the POIS will begin with a higher dose of serotonin. That is, you can reduce histamine or serotonin or drink NSAIDs, and the effect will be the same. But everyone has different proportions of inflammatory agents, so different drugs help everyone.

slon_ik

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Re: Russian Poiscenter
« Reply #55 on: July 12, 2020, 11:24:52 AM »
Я считаю, что основная причина POIS это сбой в регуляции стресса полового возбуждения в ЦНС. Это может быть генетический сбой в гипоталамусе или миндалине. Или могут быть аутоиммунные проблемы на медиаторы полового возбуждения и оргазма. Один из вариантов описан выше, это проблемы с серотонином и тучными клетками.

Я уверен, что POIS не связан с аутоиммунным на сперму, так как тогда бы у нас от спермы были красные пятна коже, а их нет ))

Так же я уверен, что проблема именно в голове. Мы хотим секса больше, чем можем себе позволить. Я это называю гиперсексуальностью. Если бы это было не так, то мы были бы или асексуалами, или импотентами. То есть наш организм не понимает, что не вытягивает стресс полового возбуждения, и это есть основная причина POIS.



I believe that the main reason for POIS is a failure in the regulation of stress of sexual arousal in the central nervous system. This may be a genetic malfunction in the hypothalamus or tonsil. Or there may be autoimmune problems on mediators of sexual arousal and orgasm. One option described above is problems with serotonin and mast cells.

I am sure that POIS is not associated with autoimmune sperm, since then we would have red spots from the sperm of the skin, but they are not))

I'm also sure that the problem is in the head. We want sex more than we can afford. I call this hypersexuality. If this were not so, then we would be either asexuals or impotent. That is, our body does not understand that it does not stretch the stress of sexual arousal, and this is the main reason for POIS.

demografx

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Re: Russian Poiscenter
« Reply #56 on: July 12, 2020, 04:25:05 PM »
slon_ik, thank you for posting!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Russian Poiscenter
« Reply #57 on: July 12, 2020, 04:29:12 PM »
Shep, thank you for connecting us!

[sent by email]
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: Russian Poiscenter
« Reply #58 on: July 13, 2020, 04:15:25 AM »
Hi slon_ik,

You may summarize your suggestions regarding what parameter to test for and how to time it in here:

https://poiscenter.com/forums/index.php?topic=3207.0

Nas

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Re: Russian Poiscenter
« Reply #59 on: July 13, 2020, 10:02:30 AM »
Я считаю, что основная причина POIS это сбой в регуляции стресса полового возбуждения в ЦНС. Это может быть генетический сбой в гипоталамусе или миндалине. Или могут быть аутоиммунные проблемы на медиаторы полового возбуждения и оргазма. Один из вариантов описан выше, это проблемы с серотонином и тучными клетками.

Я уверен, что POIS не связан с аутоиммунным на сперму, так как тогда бы у нас от спермы были красные пятна коже, а их нет ))

Так же я уверен, что проблема именно в голове. Мы хотим секса больше, чем можем себе позволить. Я это называю гиперсексуальностью. Если бы это было не так, то мы были бы или асексуалами, или импотентами. То есть наш организм не понимает, что не вытягивает стресс полового возбуждения, и это есть основная причина POIS.



I believe that the main reason for POIS is a failure in the regulation of stress of sexual arousal in the central nervous system. This may be a genetic malfunction in the hypothalamus or tonsil. Or there may be autoimmune problems on mediators of sexual arousal and orgasm. One option described above is problems with serotonin and mast cells.

I am sure that POIS is not associated with autoimmune sperm, since then we would have red spots from the sperm of the skin, but they are not))

I'm also sure that the problem is in the head. We want sex more than we can afford. I call this hypersexuality. If this were not so, then we would be either asexuals or impotent. That is, our body does not understand that it does not stretch the stress of sexual arousal, and this is the main reason for POIS.

Slon the reason I like your theory is because I have pure OCD that started with POIS. I also have many serotonin related issues such as depression anxiety and PTSD.
Do you think we can test the SERT genes genetically to prove if there is a genetic failure?
Low serotonin can also explain the Premature Ejaculation issue many of us suffer from, since increasing serotonin also increases the duration of sex. But I also have POIS from smoking cigarettes, do you think that this can also be related to serotonin?