Author Topic: POIS - a complication of Mercury Toxicity? Porphyria?  (Read 3431 times)


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Re: POIS - a complication of Mercury Toxicity? Porphyria?
« Reply #60 on: March 21, 2020, 08:53:30 AM »
Hey Milestone I am also seeing a functional med doc atm. However the supplements I am on are quite different;
Liposmal glutathione,Vitamin C, Bentonite clay, folinic acid

I plan to add Vitamin D with k2, vitamin b minus complex, Vegetable juicing, antifungal drug, grapefriuit seed extract, charcoal

What supplements from your stack have you have found the most helpful?


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Re: POIS - a complication of Mercury Toxicity? Porphyria?
« Reply #61 on: March 21, 2020, 09:26:17 AM »
The true answer at the moment is just full abstinence, and taking one day at a time.

The reaction I have is so severe that its debilitating, no matter whether it's from sex or masturbation.

I think it's in part due to how addicted I was to pornography, and I may be dealing with some glial-priming effects as well in the brain, and / or dopamine & opioid receptors that are kindled / over-excited.

For me, the POIS symptoms feel like extreme Alcohol / Benzo withdrawal, which is a nightmare on earth. Tremors, insomnia, hyper-vigilance, bi-polar reactions, depersonalization, burning blood vessels, pain in every part of my body, you name it.

Another element that could be at play is psychosomatic, because now I am correlating sexual activity / gratification with an immense amount of guilt / shame due to my focus on overcoming this addiction. I cut porn cold-turkey back in September of last year.

For me, I think it's a lot of comorbid issues:

* Gut Health / IBS (hence part of the supplement stack + probiotics + new supplements on the way)
* Immune Health (hence the other part of the supplement stack + diet changes)
* Viral Load / Contracting HSV1 within the past 5 years (re: detox foods)
* Radical change in my diet mid-last year (went very clean, very abruptly)
* Abruptly stopping omeprazole (used daily for over a decade)
* Abruptly stopping pornography
* Experiencing intense food poisoning middle of last year / ER Doctor put me on Bactrim which I had an extremely adverse reaction to (and may have wiped out my microflora)
* Prostate Damage, which is inflamed and may be infected (occurred middle of last year, thought nothing of it, visiting a urologist next week)
* Dealing with cognitive swings (anxiety / depression / anhedonia) due to dependence-like withdrawal of my pornography addiction (balancing dopamine / opioid receptors)
* Anxiety-induced Hypochondriasis (hence all of the above)

I developed POIS in the middle of last year, after all of the above happened.

Other stressors can also now trigger POIS-like symptoms for me including sodas (excessive sugar / caffeine) and alcohol (half a beer will do it).


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Re: POIS - a complication of Mercury Toxicity? Porphyria?
« Reply #62 on: March 25, 2020, 09:07:17 PM »
So, some updates...

I got more blood work back.

One of the tests performed was for genetic mutations indicating problems with MTHFR.

From the internet:

"What is an MTHFR mutation? Methylenetetrahydrofolate reductase, or MTHFR, is an enzyme that breaks down the amino acid homocysteine. The MTHFR gene that codes for this enzyme has the potential to mutate, which can either interfere with the enzyme's ability to function normally or completely inactivate it"

My test shows positive for one copy of the A1298C variant.

What this means is that I am not methylating properly (converting nutrients from my diet into active vitamins, minerals, and proteins my body can use).

Here is an article from Parsley Health (who are also my functional docs) on the issues relating to MTHFR gene mutations:

Here's a video on methylation & homocysteine levels:

Here's what stands out to me:

* MTHFR malfunctions cause deficiencies, particularly in B vitamins, manufacturing adequate neurotransmitters, and neurotransmitter protection
* low levels of vitamin B6 and B12 are risk factors for mild cognitive impairment
* Changes in the body's ability to control homocysteine levels
* Elevated homocysteine is related to neuropsychiatric issues
* Problems with detoxification
* Problems controlling free radicals and oxidative damage
* Related "gut dysbiosis" problems

This old thread from 2018 is very relevant:

My blood work shows I am also very high in Estrogen levels. It seems poor methylation can form a build-up of estrogen as a byproduct (and probably my reduced sexual activity).

My previous pornography addiction may have been a byproduct of my body trying to control and balance my hormones, neurotransmitter deficiencies, and active methylation issues.

From what I am seeing, the cascade of hormones released from orgasm is compounding everyone's methylation problems, which may be due to a hormonal and / or immune imbalance in the body.

If the body is actively fighting a chronic infection, it may not be able to deal with the flood of hormones released from orgasm. The body then likely doesn't have enough stores of vitamins to repair and replace the vial nutrients lost during orgasm and others needed to replenish sperm and related hormones. This correlates to people being 100% cured after removing chronic infections or toxins, such as mercury amalgams, wisdom teeth, or colon dysbiosis (coffee enemas & probiotics). Fits the equation outlined in this likely well-known video:

All of this also aligns with Nanna1's scientific breakdown of the cascade, as well as the supplements recommends to correct:

Supplementing with things like NAC, SAMe, Taurine, Niacin / B6, and Testosterone are ways of improving the methylation process and / or balancing the hormonal & immune response dysfunctions that people are experiencing from ejaculation. Things like Grapefruit Seed Extract have a similar effect to antibiotics which help in fighting active bacterial, fungal or parasitical infections.

The vasoconstrictors he recommends may help prevent histamines from creating permeability in the blood vessels that cause oxidative damage from mast cells / white blood cells radically attacking any dormant viral load you may have throughout your body (triggering the pain and myalgia symptoms).

All of this is likely because there is an imbalance in the body that is preventing these typical methylation processes from happening naturally. Everyone may have different imbalances that they need to treat.

My guess on "my personal" imbalance (that peaked last year as symptoms surfaced) is gut dysbiosis, low stomach acid, chronic infection (which I have yet to identify), viral load, and / or toxins (likely a mix of everything).

I have an appointment with my functional doctor from Parsley Health in April to go over all of my blood work and dig into treatment. I will report back as I learn more.

In the meantime, my protocol will focus on healing the gut, reducing inflammation, reducing stress, repairing neural damage, abstinence, and staying on the stack of antioxidant foods and supplements I noted above.


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Re: POIS - a complication of Mercury Toxicity? Porphyria?
« Reply #63 on: March 26, 2020, 01:50:25 PM »
Very interesting, Millstone.
Certainly keep us posted !