Author Topic: "Depression is caused by inflammation in the brain"  (Read 593 times)

Investigator

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"Depression is caused by inflammation in the brain"
« on: May 03, 2018, 02:25:08 AM »
I stumbled across this article, which would be of interest to us:
http://www.dailymail.co.uk/news/article-5675941/Cambridge-psychiatrist-claims-depression-actually-caused-inflammation-brain.html

There are obvious links between symptoms of depression and of POIS. Also, remember that the French Professor Gerard Amarenco says he has tried to treat POIS with antidepressants, but it didn't work. Many in the forum believe that POIS is caused by an inflammation in the brain - here is some more support for that view. And all the connections with the vagus nerve.

In my lab results, I had lower amount of white blood cells - no wonder, as this article explains in down-to-earth language - that's because they go and fight for the inflammation.

@the moderators: I wasn't sure if this is the right place for this post - please let me know where it should go instead. 

Observer

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Re: "Depression is caused by inflammation in the brain"
« Reply #1 on: May 03, 2018, 05:23:29 PM »
Really interesting Investigator.

I have marked some specific points:

Patients with severe depression might benefit from electrical stimulation of the vagus nerve, which runs from the gut to the brain. This treatment is known to calm inflammation. Changes in diet and lifestyle could be effective, too.

This could be why SSRIs don’t benefit depressed patients with high levels of inflammation — as the raw material for making serotonin isn’t available.

(...)

It’s not just illness and infection that cause inflammation. Obesity is linked with it, especially the fat stored round the middle (a source of inflammatory cytokines). Habits such as smoking, not exercising and a high sugar diet all combine to keep inflammation raised.

However, about 80 per cent of depressive episodes are connected with stress, says Professor Bullmore, citing the example of a man who starts divorce proceedings being ten times more likely to suffer depression than the general population; the risk for his wife is 20 times greater.

(...)

One intriguing new treatment for depression could be nerve stimulation, he suggests — specifically stimulation of the vagus nerve that runs from the gut to the brain. This helps keep automatic processes such as the heart rate stable.

It is now known that it does the same thing for inflammation. Indeed, research with rheumatoid arthritis patients has found that 20 minutes a day of vagus nerve stimulation led to a rapid, significant drop in inflammation.



b_jim

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Re: "Depression is caused by inflammation in the brain"
« Reply #2 on: May 05, 2018, 01:50:51 AM »
Tryptophan is used to produce neurotoxic molecules instead of serotonin/melatonine. This is the key.

Anyway, STRESS (physical and psychological) and junkfood is an engine of this mechanism.
When I work too much, I'm depressed. Not because I'm "sad' but because I produce too much cortisol to resist to the fatigue.

Maybe serotonin is enough to explain Pois ! It seems this neurotransmitter controles all the body, other neurotransmitters, hormones, bloodglucose... Serotonine is life and when when the levels are at the lowest, the death is close.
« Last Edit: May 05, 2018, 01:52:58 AM by b_jim »
Taurine = Anti-Pois