https://en.wikipedia.org/wiki/Psychoactive_drug#Affected_neurotransmitter_systemsThis can be helpful to understanding mechanics of POIS, in my experience nicotine and caffine help me but they stimulate two different receptors, serotoninergic drugs do very little, now I am interested in the nootropic drugs who can help with cognitive POIS I think, of course don't consider to try illegal drugs, I am using smoking to relieve POIS and sometimes feel I am doing wrong and it is legal even if unsafe, an illegal drug will do more harm than good.