My experience is this - It's not a long term solution for me. When in POiS and feeling bad, mestinon temporarily increases cognative function with better focus, memory, and social integration. However, after 1.5 to 2 hours the medication wears off and creates a withdrawal that actually feels worst than before even taking the medication. The withdrawal includes slow cognative function, irritability, and I even get the 'shakes'. This is only my experience and hope yours is totally different.