Author Topic: From my friend, Kurtosis  (Read 14088 times)

udomhorn

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From my friend, Kurtosis
« on: September 07, 2014, 06:20:51 AM »
 Hi, First time sending a message on this forum in years. I've no idea what's going on here or the Naked Scientists as I don't read them anymore. After lots of emails asking me was I really cured or trying to tell me I wasn't I just abandoned the forums. I haven't had POIS symptoms in a long time. I had a noticeable and dramatic improvement following treatment for SIBO and yeast infection. I believe POIS is effectively an epigenetic disorder. Read a bit about what Martin Pall has written about Nitric Oxide disorders. I think that we get an infection or virus and it weakens our immune system. Once that happens our ability to produce a correct immune response is compromised. In my case, I have several genetic mutations which would made it difficult for me to produce enough tetrahydrobiopterin (BH4). (Research GCH1 and MTHFR mutations, I wrote a bit about them on the other forum). B3/niacin is a co-factor in the recycling of BH4 within the body and I think that what happened was that following a gastric infection in puberty (which led me to become ill for 3 months) I never completely recovered and, I believe, existed in a low BH4 and NO state for years. This led to increased ammonia, symptoms of B3 depletion (a mild form of pellagra) and low levels of glutathione which leads to acne and other signs of inflammation.Treating SIBO gave my body some time to recover and made new nutrients easier to absorb. My glutathione levels increased, I got less acne etc. I believe that the benefits people get from B3 are increased BH4 recycling which reduces inflammation in their body. Insufficient NO and higher levels of superoxides, are hypothesised by Pall to lead to cardiovascular problems, fatigue and inflammation. Low BH4 may lead to low dopamine (or fluctuating levels of dopamine/serotonin) which may explain some of the cognitive symptoms I got following an O. See the Pall Protocol athttp://chronicfatigue.about.com/od/treatmentprotocols/a/Pall_Protocol.htmI learned more by forgetting about the sex element of POIS and just researching chronic fatigue syndrome. There are people with ME and CFS on those forums who have sexual symptoms but they don't talk much about them. Honestly, I think the focus on orgasms here is useful only in the indication of a reduced Nitric Oxide level and dopamine problem i.e. an indication of an issue with blood flow. They complain about dizziness, nausea and other blood flow related symptoms of the Phoenix Rising Forums also. The sex bit of POIS is possibly a "red herring". I think of my symptoms as Chronic Fatigue Syndrome that was made worse by orgasm. I was never completely better even without Os but I didn't know that because I couldn't stop having them I suspect that applies to other POIS sufferers. I don't take niacin before sex anymore but I still take a multivitamin every day. I studied the Pall protocol and my diet is focussed on creating and recycling bh4.I can't say what will work for you but I can tell you what worked for me. 1) Treat SIBO and a yeast infection if it exists. Note that there's some evidence that niacinamide helps treat  a yeast infection. Seehttp://www.livestrong.com/article/509942-niacin-yeast-infections/Probiotics can be useful here but if you're diagnosed with SIBO then don't be afraid to take the antibiotics. I'm glad I did. The doctor who prescribed me the antibiotics also told me to take less refined sugar. When you're tired, the solution isn't a sugar fix. He was adamant about that. Sugar just creates bacterial and yeast imbalance. There's enough in most foods and complex carbohydrates are a better source of energy. It was tough to stop eating sugary cakes and sweets but worth it. 2) Take a good multivitamin with active b vitamins and extra antioxidants. Some of the best have reduced glutathione, and alpha lipoic acid. The latter will help recycle glutathione in the body and increase the effectiveness of BH4 your body creates. ideally the multivitamin has some niacin and niacinamide. The Pall Protocol M-VMA is good. Douglas Labs Ultra Preventative is good. Pure Encapsulations O.N.E.  Thorne Extra Nutrients. There's a range of them that are fine and have a good selection of antioxidants as well as multivitamins. 3) Consider a supplement that are purported to increase the amount of NAD+ available in the mitochondria of cells. There's a few candidates that might do this. NADH had odd affects on some POIS sufferers. I liked it though. Resveratrol is great in my opinion as is pterostilbene. A combination is probably even better. There's talk of supplements like nicotinamide riboside being good but I only tried that once. I found it similar to resveratrol but more expensive. I don't really care much for particular brands but I take 100mg of 98% standardised trans-resveratrol extract in the morning and afternoon. This protocol is cheap and easy It's a multivitamin and resveratrol. Limit sugar drastically. Get exercise again and start living your life. Simple. Seehttp://forums.phoenixrising.me/index.php?threads/no-onoo-cycle-uncpoupling-by-resveratrol.7040/for some research that suggests a mechanism of action for resveratrol. 4) Forget about POIS and get on with your life. It just goes away. I think POIS for me was primarily about having low BH4 levels and consequently low Nitric Oxide. Once I didn't have problems getting nutrition from food and with some vitamins so I could recycle my Bh4 effectively everything got better. I've had some acne twice in 6 months. Both times, it cleared up in 2 days.  I used to have it every single week. So it's not just the orgasm related brain fog that's gone, there are obvious visible changes. The acne didn't clear up because of age or any other reason, that I can tell, because I had bad acne in my mid 30sI won't be back to this forum because I'm very busy. If you want to message me, that's fine, but I'm not going to reengage with either NSF or Poiscenter. The forums take up too much time and it's entirely possible we all have different illnesses. I had other posters try to talk me out of SIBO treatment, resveratrol and other stuff that worked for me because it didn't work for them or didn't work as they wanted. I don't know anymore. I wasted months of my life trying to come up with a cure for everyone and justifying my posts. You've asked for help and I respect that.  I'm sure the "professional researchers" will have their say and that's a good thing. The POIS research grant was a big milestone for this forum. But I needed to experiment faster and take more risks because I wanted to move on with my life. Good luck my friend, KReport To Admin

kurtosis

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Re: Treatment

« Sent to: Shinjiro on: August 25, 2014, 04:59:55 PM » « You have forwarded or responded to this message. »ReplyQuoteDeleteI'm not sure we're in the same boat. I have no POIS symptoms anymore. I'm happy with that. If POIS has a genetic basis then I don't expect it can just be switched off overnight. If that's the cure you imagine, with no ongoing medication, then you may be disappointed. Perhaps, I'd be fine without a multi-vitamin and resveratrol. I haven't tried to find out.If POIS comes from a viral infection e.g. HHV-6 then it won't be curable as such. The patient would have to take anti-virals when there are flare ups of the virus. Interestingly, vitamin D is used as a treatment for Herpes and some people with Epstein-Barr report improvement with vitamin D. Low vitamin D also effects testosterone and dopamine levels. Complimentary supplements in treating viruses are lysine and resveratrol as lysine inhibits the virus while reseveratrol and vitamin D increase the immune response. Some people may have a problem with low BH4. If they do, good, they should treat it. If they don't, they have problems other than what I had and I can't help. If you have SIBO it will create nutrition problems, fatigue etc.. Get it treated. My guess is that there are different illnesses on this forum. Some people are mentally ill perhaps and their POIS is anxiety related. I can't fix all these problems so I went away. It is easier for me to be happy with my own good health rather than spend hours every day trying to convince other people I'm OK. Why would I, they'd just resent me for being better but not being able to help them. Drinking red-bull and taking vitamin D is taking vitamins and caffeine to treat POIS. If that makes you happy, keep going. But if vitamin D is really making you better then it's advisable to get tested by your doctor for viral infections, EBV, Herpes etc.. Explain to your doctor your fatigue symptoms and see if they can help. Just try to make yourself better and don't try to fix POIS for everyone. One thing I learned, doctors have some ability to treat fatigue related illnesses and to test for viruses, bacterial overgrowth, vitamin deficiencies etc. They have no idea how to treat POIS and telling a doctor you have it will just make them think you're a hypochondriac Regards, KReport To Admin

kurtosis

Sr. MemberPosts: 370Scientist, Engineer, INTJ type

Re: Vitamin D3 (Fat)

« Sent to: Shinjiro on: September 04, 2014, 01:36:21 PM »ReplyQuoteDeleteSounds like a promising angle on treating POIS. I had a few posts about FADS2 enzymes on the Naked Scientists. I also wondered about POIS connection to delta-6-desaturase enzymes in the past. http://en.wikipedia.org/wiki/Fatty_acid_desaturaseAlso read http://www.encognitive.com/node/5050Fascinating. There's a possible connection between viral infections and autoimmune disease affecting lipid oxidation. Check outhttps://www.naturesplus.com/products/productdetail.php?productNumber=1045&criteria=keywordSearchResultsLooks a good D3 supplement and has added resveratrol. It's worth trying. Good luck. Regards, Kurtosis

 And Mr. Demo and Daveman after reading this. Don't forget to block my account. :)

Bulbo

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Re: From my friend, Kurtosis
« Reply #1 on: September 08, 2014, 07:22:23 AM »
Thank you udomhorn for forwarding kurtosis's message. Thank you kurtosis for helping us. I appreciate any help. I am going to try this regimen
Thanks udomhorn and kurtosis

Colm

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Re: From my friend, Kurtosis
« Reply #2 on: September 08, 2014, 08:51:22 AM »
Thank you udomhorn for forwarding kurtosis's message. Thank you kurtosis for helping us. I appreciate any help. I am going to try this regimen
Thanks udomhorn and kurtosis
PS. (Sender) Udomhorn message supposedly from Kurtosis, was up as (Sender) Shinjiro yesterday. Seems a bit peculiar.

Probably a genuine message, as this is the style of content I have seen Kutosis write about from his past posts.

Shinjiro might be over-stating the "friend of Kutosis bit". Who knows !

Interesting content I guess.
« Last Edit: September 08, 2014, 08:54:20 AM by Colm »

Daveman

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Re: From my friend, Kurtosis
« Reply #3 on: September 08, 2014, 10:41:49 AM »
udomhorn:

I know you are actually another user who has posted here recently, so it isn't true what you say about not having been on the forums for some time.

Given other discrepancies in that which this other user has written, I am not sure much of what is written can be taken seriously. I guess the rest have to decide for themselves.

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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Re: From my friend, Kurtosis
« Reply #4 on: September 08, 2014, 03:34:46 PM »
Thank you udomhorn for forwarding kurtosis's message. Thank you kurtosis for helping us. I appreciate any help. I am going to try this regimen
Thanks udomhorn and kurtosis
PS. (Sender) Udomhorn message supposedly from Kurtosis, was up as (Sender) Shinjiro yesterday. Seems a bit peculiar.

Probably a genuine message, as this is the style of content I have seen Kutosis write about from his past posts.

Shinjiro might be over-stating the "friend of Kutosis bit". Who knows !

Interesting content I guess.

I agree with everything you say but...I would not trust the content. We have seen nothing but fakery and NONSENSE from the schizoid team of Udomhorn/Shimjiro Multiple Personalities :)     Best current treatment is SAK   (Swift  Ass Kick)!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Stef

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Re: From my friend, Kurtosis
« Reply #5 on: September 08, 2014, 06:33:16 PM »
"Thank you udomhorn for forwarding kurtosis's message. Thank you kurtosis for helping us. I appreciate any help. I am going to try this regimen
Thanks udomhorn and kurtosis"

Bulbo -- specifically what regimen are you planning to follow?

Stef

Prancer

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Re: From my friend, Kurtosis
« Reply #6 on: September 08, 2014, 06:43:12 PM »
Thank you udomhorn for forwarding kurtosis's message. Thank you kurtosis for helping us. I appreciate any help. I am going to try this regimen
Thanks udomhorn and kurtosis
PS. (Sender) Udomhorn message supposedly from Kurtosis, was up as (Sender) Shinjiro yesterday. Seems a bit peculiar.

Probably a genuine message, as this is the style of content I have seen Kutosis write about from his past posts.

Shinjiro might be over-stating the "friend of Kutosis bit". Who knows !

Interesting content I guess.

I agree with everything you say but...I would not trust the content. We have seen nothing but fakery and NONSENSE from the schizoid team of Udomhorn/Shimjiro Multiple Personalities :)     Best current treatment is SAK   (Swift  Ass Kick)!

Wow, thanks guys. I spoke too soon. Didn't realize the udomhorn thing until Daveman mentioned it. I removed my last post because I don't have confidence in his [udomhorn's] message relay's accuracy yet.

And I agree demografx! SAK those lunatic fakers out for good!
« Last Edit: September 08, 2014, 08:15:11 PM by Prancer »

Nightingale

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Re: From my friend, Kurtosis
« Reply #7 on: September 08, 2014, 09:42:35 PM »
This is exactly where kurtosis was with his POIS when I last talked to him this spring. I never could find success with his treatments, and a large part is that I can't get past his step 1) to fix the gut. I am having such a hard time with this... I'm going to have an upper and lower endoscopy next week, and maybe a pill cam...

I have one big problem with what kurtosis says here:

Quote
The sex bit of POIS is possibly a "red herring". I think of my symptoms as Chronic Fatigue Syndrome that was made worse by orgasm.

What about there being no women with POIS? I have not encountered or heard of a woman having POIS, but men and women both have Chronic Fatigue Syndrome. Acutally, more women than men to my understanding. Why aren't we seeing the women with BH4 deficiencies that complain of a worsening of symptoms after sex? POIS is sex specific it seems, so I don't think there's any taking sex and orgasm/ejaculation out of the answer.

As far as kurtosis not wanting to engage with us, I think it's too bad... he doesn't have to try and save us all. He spent a lot of time trying, and it frustrated him. I wish he could just be around and engage as someone who has recovered from this illness... it's a really great thing for others to see that it's possible to be well and to be encouraged.
Turmeric and Rosemary 30-45 minutes before orgasm for anti-inflammatory and immune support has helped me a lot. Faster and easier than niacin approach.

kurtosis

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Re: From my friend, Kurtosis
« Reply #8 on: September 09, 2014, 05:22:38 AM »
Hi,
I'm posting to the forum because I'm shocked about this thread.
I had a private message exchange which I obviously did not intend to become a thread on poiscenter. I hadn't checked the Udomhorn/Shinjiro conversations as I just don't have enough time. The only reason I came back is I've received messages about this thread and decided to check them out during some downtime today.

In terms of people on the forum who I consider friends, I've exchanged enough emails with Nightingale and B_Daniel to believe I know them pretty well and like them both. Shinjiro seemed a nice guy but I don't think it was reasonable to post this without my permission and I surely didn't give permission. These are my words however so Nightingale called it correctly.

In terms of contributing to the forum, I've been too busy and I was worn out trying to find a universal cure. Also, nightingale, I'm pretty sure there were female POIS sufferers who post to the NSF. As I said to a few of you in messages over the years, there's accepted medical literature on women having an apparently allergic reaction during sex. Sneezing etc. The reactions can be caused by excessive histamine release or a reaction known as seminal plasma hypersensitivity. It was even mentioned in a daily newspaper in the UK last year. (Although not one I'm a fan of to be honest :))

Anyway, I'll go back to retirement (or whatever this is) but if I want to post to this forum in future I'll do it myself without assistance from a 3rd party. I will not communicate further with anybody who takes a private message and posts it on a public forum.

demografx

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Re: From my friend, Kurtosis
« Reply #9 on: September 09, 2014, 09:02:12 AM »

And I agree demografx! SAK those lunatic fakers out for good!


Shinjiro begged for - several times -- and received what he wanted - to be banned from the forum. "Udomhorn = Shinjiro" is on thin ice.

Keep in mind, please, that the last thing Daveman and I want to do is ban **anyone**. Everyone  here suffers as POISers, but we cannot allow for malicious, disruptive intent in this forum. We are all in the business of making each other BETTER...not to harm, or malign one another or to impede progress.

Edit: banned or not, ANYONE can still read this forum and benefit from all the good we will continue to provide POIS sufferers worldwide. From Rutgers Research to all other ways we have/ will find to combat this most dreadful malady of ours !
« Last Edit: September 09, 2014, 09:27:05 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: From my friend, Kurtosis
« Reply #10 on: September 09, 2014, 09:05:32 AM »
Segue : this feels like a good time to reiterate our Founding Principles - Demo & Daveman



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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Colm

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Re: From my friend, Kurtosis
« Reply #11 on: September 09, 2014, 03:23:00 PM »
Good idea putting that up Demo

demografx

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Re: From my friend, Kurtosis
« Reply #12 on: September 09, 2014, 05:39:36 PM »
Thanks, Colm
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Prancer

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Re: From my friend, Kurtosis
« Reply #13 on: September 10, 2014, 12:54:04 AM »
I can never understand WTF people like Shinjiro are actually trying to accomplish anyway. So Shinjiro tells us he's cured, and then he keeps repeating the same damn sh*t over and over again, shoving it down people's throats (just like that other guy did at NSF). Once or twice is enough! We get it. If someone wants to follow someone else's cure, they will. Otherwise, kindly refrain from being annoying to everyone else. If people have questions, they will send you a message asking for more details.

Edit: And I just now saw kurtosis' post and can definitely understand how frustrating it must be when someone like Shinjiro makes his private conversation public without his permission. Glad to see those really were his words though and not something Shinjiro made up...like he pretty much did with everything else for reasons unknown.
« Last Edit: September 10, 2014, 04:12:22 PM by Prancer »

Daveman

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Re: From my friend, Kurtosis
« Reply #14 on: September 10, 2014, 06:09:05 AM »
As far as POIS being potentially a collection of different problems, without a root cause.... it certainly is all strange. You Kurtosis are happy to have found YOUR solution, and inasmcuh as I know you tried damn hard to find a common element, it has been too difficult to really pin down anything. Yet I can't help but beleive that there still is some root cause.

One reason I say this is that my POIS has changed a great deal in these last months (maybe 18 or so). I have always been more physically affected, and still am, however it has moved from being muscular to gastric. Also I am finding that it's increasingly difficult to find relief in Niacin, still when it works it works well, but it's a lot harder to get it to work.

In these same 18 months, my life has changed quite a bit as well. But one thing I have always noted with POIS, is that it always seems to exaggerate some other underlying disorder, whether that be muscular, gastric, or even cognitive. Sex and orgasm are always the trigger, and whether its gastric or whatever, there's always that "POIS feeling" in the background.

So, there's such a tendency to go after treatments based on symptoms, where those symptoms can change depending on the underlying flare up. In one way POIS seems like a red herring, but I think it's actually the other way around. The red herring is7are the symptoms.

There is something that goes on during the orgasm that triggers the mechanism... what a puzzle. Hopefully, somewhere, some day, we'll understand this thing.

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!