Physiology of hot flashes

[b_jim]

I finally found a scientific document to explain CLEARLY how does the hot flashes work.
It's very interesting. PDF File In french, Bouffees de chaleur et traitement hormonal du cancer de la prostate

Very simply, 3 points :

- The cause of hot flashes is the increased levels of catecholamine in hypothalamus, center of temp regulation. The main catecholamine is noradrenaline.

- Opiod peptides down-regulate (=decrease ) level of these catecholamines then decrease hot flashes.

- Steroid hormones (Testosterone, DHT, oestrogens/progesterone) up-regulates (=increase) the levels of opiod peptides.


With these element you may understand a lot of things in Pois.

[b_jim]

Hot flashes : link hormones to hypothalamic cells : KNDy cells

In french :

http://www.lequotidiendumedecin.fr/actualites/article/2012/12/12/candy-au-pays-des-bouffees-de-chaleur_631797

I think I have a better knowledge of this and maybe, I hope, a batter knowledge to understand Pois :

I said in the first post that hypothalamus is the center of thermo-regulation.
But inside hypothalamus, there is a particular kind of cells called : KNDy cells.

--

Cela étant dit, les bouffées de chaleur, comme celles survenant à la ménopause (mais aussi chez les hommes sous traitement anti-androgène) constituent une énigme.

Hotflashes during women menopause (but during anti-androgen meds for men) are still mysterious.

=> Low testosterone = hot flashes

[Vandemolen]

Very simply, 3 points :

- The cause of hot flashes is the increased levels of catecholamine in hypothalamus, center of temp regulation. The main catecholamine is noradrenaline.

- Opiod peptides down-regulate (=decrease ) level of these catecholamines then decrease hot flashes.

- Steroid hormones (Testosterone, DHT, oestrogens/progesterone) up-regulates (=increase) the levels of opiod peptides.

With these element you may understand a lot of things in Pois.

Very interesting topic B_Jim. I am very interested in the hypothalamus in connection with POIS. So if you take testosterone does that mean that you will get less hot flashes and reduce the POIS?

[berlin1984]

There is a supplement marketed for women in menopause that claims to reduce hot flashes by 90%..
It's made from some kind of pollen and called "Serelys".

Maybe makes sense to check if it can somehow be useful to us.
(by "us" I mean male POISers, but input by female POISers is appreciated too)