Author Topic: I am wondering if any of you guys have the same experience as me...  (Read 4030 times)

asdfdoc

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Hi guys,

I want to know if any of you guys have the same symptoms, experience as me. I really studied POIS and my psych symptoms past 1 year and I am not cured. I worked with multiple psychiatrists, urologists and general practitioners to figure out what's going on. But I've had no luck so far.

POIS symptoms
- extreme physical and mental tiredness for a day or two, gets tired within 5-10 minutes after O, red and hot flushing within 30 minutes after O. Sleep is the key to getting better. If I pass out and wake up, I get a lot better. I don't have itchy or runny noses/eyes like an allergy reaction. I just wanna say that I am just really tired.

Physical differences/symptoms: this portion is something I've been observing about myself for a while in general when I am not going through POIS. Maybe this is coincidence, but who knows?
- My pupils are super small. They do dilate when I go in the dark area, but the range of dilation is not as dynamic as others. When my pupils are fully dilated, it's only about 50% of my iris, while others' eyes are like 80-90% dilation at full dilation.
- I was born with lazy eye, got it fixed eventually.
- My pupil size is different, one of them is about 1mm diameter larger than another.
- I sleep/drive/study with mouth open. I do not have sleep apnea.
- premature ejaculation
- I think I have slow metabolism, I gain weight easily, but I also lose weight easily if I work out.

Psych
- OCD, anxiety: these are the driving factor and motivation factor for me. Unfortunately I cannot function without anxiety.
- ADHD: messy, unorganized, no filter
- It's funny because I am OCD and ADHD. I am messy, unorganized, never read a book cover to cover, yet I tend to do well in school because I have this anxiety of failure in career. At the same time, messiness caused by others (roommates) gets under my skin and I cannot control my OCD. I always push things back and work on/study a day or two before the due date.
- doc ruled out bipolar, but I am still skeptical. I am seeking a different doc soon, so tbd on this. I don't have any impulse buy problems or sleep problems. I am not depressed, rather, I feel apathetic most of times. I do not really feel sadness or happiness.
- my personality, I have close friends but I tend to push people away because I have "no filter". I read carnegie's book on how to improve it, and went through therapy but it's really difficult to fix. My OCD isn't a big help in making friends. I feel edgy most of times, I am just a very anxious person.

Med reactions
- I respond really sensitive to stimulants. Right now, I am going through lexapro withdrawal (will talk more later), so reaction is different but when I first tried them, amphetamine family (adderall, vyvanse) drove me manic, 1/4 of the smallest dose 5mg ritalin was effective for my ADHD
- adderall was somewhat temporarily effective in treating pois, ritalin was not.
- 5htp was effective in treating pois and anxiety problems.
- St. John's wort at normal dosage gave me hallucinations and drove me manic
- Wellbutrin at lowest dosage 100mg SR made me apathetic for a week and caused a psychotic episode on day 7, I became delusional and hallucinated.
- Lexapro worked for me at 10mg. It killed anxiety and my OCD. The problem was I couldn't carry on my normal duties due to lack of anxiety. I wasn't "freaked out" enough to do what I am supposed to be doing. Lexapro 15mg drove me manic, mild serotonin syndrome, jerking movements, tensed up, felt really drugged up.
- Lexapro did nothing to my libido, my libido was still very high, it didn't fix my premature ejaculation problem.
- Lexapro helped me with POIS symptoms, reducing it 80% or so. However, on lexapro, stimulants stopped working. Stimulants made me really tired and put me to sleep.
- Lexapro made my eye dilation bigger and more dynamic! I noticed myself driving / sleeping with my mouth closed.
- Extremely long lexapro withdrawal, it's my 6th week off lexapro after being on it for 4 months, I feel really fatigued and I have really bad headache. No stimulants work on me, they just put me to sleep.
- Benzos (xanax), Doc prescribed me benzos just in case I have another psychotic event from drugs or just to take it before giving presentations. Benzos do work, but they make me super tired. It almost feels like I am going through POIS.

What I think
- I think GABA plays a big role in my case of POIS (feels similar when taking Benzos)
- serotonin system plays a role (OCD/Anxiety/Improvement of POIS)
- dopamine, I am not too sure, I feel like I am already high in dopamine, I feel really motivated. But who knows?
- some kind of feedback mechanism? I can think of O like a panic attack. Flushing all the neurotransmitter out and intense stimulation causing negative feedback loop, flooding synapse with gaba?

23andme
- nothing significant, no genetic problem for ADHD, chronic depression


any similarities or differences? please reply...
« Last Edit: April 13, 2013, 12:29:53 AM by asdfdoc »

Clycos

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Re: I am wondering if any of you guys have the same experience as me...
« Reply #1 on: April 13, 2013, 01:38:24 AM »
Hey guys I didnt know where to post this so I thought this topic was suitable. Sorry guy on top of me this is not a reply to your post. I was wondering if anyone else experiences this thing where whether your under POIS or not, at night times you always feel right and clear minded?

I have noticed this trend and I have realised maybe throughout the day Ill feel sick and weird but at nigh-times I am almost always 100%

Clycos

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Re: I am wondering if any of you guys have the same experience as me...
« Reply #2 on: April 13, 2013, 01:49:10 AM »
Hey finally I just read your post and I thought it was really interesting. My honest educated opinion is to stay away from psychiatrists; they tend to only treat symptoms and not really the cause. You have to understand drugs are usually given to patients to amplify the effect of therapy itself, however POIS is not psychological, it is physical and there is absolutely no reason why you should damage your brain to temporarily treat symptoms. Unfortunately, drugs treat certain symptoms but then create new ones.
I suggest you don't go deeper in to that path, a clinical psychologist can help you deal and manage issues with POIS.

asdfdoc

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Re: I am wondering if any of you guys have the same experience as me...
« Reply #3 on: April 13, 2013, 03:42:37 AM »
well, my hypothesis is that pois arise from neurochemical imbalance, and I have ocd/anxiety/adhd to treat anyway. i think they are linked, in my case at least...

as for yours, I don't feel clear and right minded at night :(.
« Last Edit: April 13, 2013, 03:45:21 AM by asdfdoc »

Clycos

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Re: I am wondering if any of you guys have the same experience as me...
« Reply #4 on: April 13, 2013, 11:57:45 AM »
You have a point, however I would assume doctors know how to objectively test neurochemical imbalances in the human brain by now. Do you have any hard evidence that neurochemically you are off balance?

demografx

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Re: I am wondering if any of you guys have the same experience as me...
« Reply #5 on: April 13, 2013, 01:56:46 PM »

I would assume doctors know how to objectively test neurochemical imbalances in the human brain by now.


Fascinating new developments in analyzing the human brain. Here's one in today's news:
http://touch.latimes.com/#section/-1/article/p2p-75334338/
« Last Edit: April 13, 2013, 02:00:12 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business