I think Sibo, or more appropriately, 'Intestinal permeability', is the mother of all diseases, and could very possibly be even root-cause of POIS. To dig one steep deeper into the foundation even, cellular integrity, adhesion molecules, membrane structure that comprises skin/collagen improving that, maybe could be better approach to solving intestinal permeability instead of the common solutions I read about - like reducing bacteria etc. I wish we had a lot of molecular biology scientists here.