Best pre-packs before O

[Monte]

If you allow I start new thread about our best pre-packs or pre-packs which we are going to implement. If you can, please write your best sets, you can put short description how these remedies work. If you also have knowledge you can indicate which type od POIS you suspect.
I am preparing for implementation my first pre-pack, which would reduce intensity of POIS.
Few main symptoms:
- deterioration of cognitive processes and intellectual abilities
- emotional and social problems
- jumping muscles, trembling muscles
- pain in the whole body (bones, muscles)
- rather no burning/itching eyes

So I think to take:
- antihistamine - for example claritine (H1 blocker, decrease activity of histamine and mast cells)
- taurine (lowering prolactin, increasing gaba)
- pseudoephedrine (acts on α- and β2-adrenergic receptors = mast cell inhibition) or another NLPZ like diclofenac
- drotaverine (anti-inflammatory) ? without a prescription or better Prednisolone if I will get prescription
- acyclovir (works when we have HSV-1)
- melatonin (to inhibit noradrenaline)
- calcium (in my case every POIS causes deficiency of calcium)

Moreover:
- lysine (inhibits HSV-1)
- carnitine
- NAC (regeneration)
- protein shake (regeneration)

Eventual:
- benzodiazepine (to inhibit dopamine and noradrenaline)

And go to sleep after O (to inhibit noradrenaline)

I don`t take quercetin because I have child in plans (any of my remedies also has a negative effect on fertility?)

I suspect that my POIS is assiociated with immunology (but I don`t exclude other reasons). When I got first time POIS I was working in strong stress and (short time) in toxic environment (I will write about it later in topic about my case https://poiscenter.com/forums/index.php?topic=3423.0).

Please write if you have thoughts on my pre-pack or if you have your own well working pre-packs.

[berlin1984]

Sounds good and interesting.

What brought you to the conclusion about calcium? Which exact form of calcium do you take? Linking your other thread here where you mention calcium: https://poiscenter.com/forums/index.php?topic=3423.msg36092#msg36092
Note that calcium is dependant on Vitamin D in the body (which then depends on K and Magnesium.. I'm not an expert there but that's what I read)

Here are some mentions of calcium in the forum:

My doctor told me yesterday that my blood test came back with a slightly higher than normal calcium level,

One last thing. I doubt if anyone with POIS needs extra calcium if they have a normal diet but they may need extra D to help absorb the calcium from the food they eat.  Extra calcium will actually bind with magnesium and cause it to be excreted so loading up on calcium supplements may take magnesium from your body. A calcium overdose would be a seizure. Some doctors believe there's a connection between calcium./magnesium imbalance and migraines.  Note that Nathan is achieving some success with a calcium channel blocker. While I think that may be too much in the long run, I think that high levels of calcium supplementation may actually worsen POIS symptoms. You're probably better off with dietary calcium and a small amount of extra magnesium and a lot of vitamin D3. Or skip the calcium and magnesium and just take the D3.  Just an opinion ...

Release of cytokines need intracellular calcium, they all go down post O. Is there a decrease of intracellular calcium inside leukocytes? IFN-g may still be climbing days later as in a type IV reaction.

Muscle stiffness, spasms post-orgasm could indicate changes in intracellular calcium concentration. Another trigger is heat/high ambient temperatures especially during rest after movement (just taking a walk) through hot environments.

Postorgasmic illness syndrome: випадок із практики
....
Calcium 2.54 mmol/L, reference range: 2,15-2,50 mmol/L
Serum Iron 37,3 μmol/l, reference range: 5,83-34,50  μmol/l

And I had my calcium checked. It was a bit high but in the normal range.

i too have vey high levels and have had calcium kidney stones removed, is this relevent i suppose only time will tell

Oh and would be nice if you could still answer the questions overe there, I'm looking for corelations

[Monte]

I take Calcii carbonas. Muon also drew attention to the calcium in the cells.

I see mast cell problems.

S. aureus can tap into allergic pathways. It can induce IL-8.
https://poiscenter.com/forums/index.php?topic=2695.msg35824#msg35824

Human Mast Cell Activation by Staphylococcus aureus: Interleukin-8 and Tumor Necrosis Factor Alpha Release and the Role of Toll-Like Receptor 2 and CD48 Molecules

There might be something going on with intracellular calcium instead of extracellular.

Don't bother talking about mast cells with your doctor, you will waste your time. Their knowledge is limited to tryptase and histamine.

Any suggestions?

Yes, ask your urologist to test for IL-8 in seminal fluid (sIL-8):
Interleukin 8 and the male genital tract

I know my problems with calcium are strange and my case may be specific.
How I discovered problems with calcium?
I was supplementing magnesium and I was feeling worse and worse, but one day ... (read below).

Discovered positive sides of calcium was very important thing to me. Once a time I was preparing myself for my cousins` wedding and I was in POIS. Magnesium didn`t help, multivitamin (with small dose of niacin) din`t work, and then I take supplement with calcium mixed with vit. D. Then I couldn`t belive but  brainfog, bad mood and pain was gone and the wedding was really great time for me. I belived that I found an antidotum for my bad condition (I thought that I have just calcium deficiency and I should just refill it, I didn`t know that is beginning of such a war). But till today calcium is one of my most important allies.

[Quantum]

Hi Monte, and welcoe to the forum !

You will find a detailed description of my pre-pack at https://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604 , along with details with my overall method for controlling my POIS symptoms.
I have been using it for over 5 years now, and it is still helping a lot.