We know that one patient cured POIS by taking norethisterone,
https://my.clevelandclinic.org/health/diseases/8260-menstrual-migraines-hormone-headaches and
https://www.healthline.com/health/headache/headache-during-period#causes shows that "After ovulation (the release of an egg from the ovary), hormone levels decline. Estrogen and progesterone levels are at their lowest right before your period. It’s this decrease that makes some women more likely to experience headaches.","Headaches in women, especially migraines, are related to changes in the levels of estrogen. Levels of estrogen drop immediately before the start of your menstrual flow (menses).Premenstrual migraines regularly occur during or after the time when the female hormones, estrogen and progesterone, drop to their lowest levels.Migraine attacks usually improve during pregnancy. However, some women have reported that their migraines started during the first trimester of pregnancy, and then went away."
On the other hand, in men, estrogen can also be produced by testosterone, maybe it is connected with the problem that why HCG and TRT can help, As far as I am concerned, non steroidal anti-inflammatory drugs and glucocorticoids can greatly alleviate my symptoms. These two drugs are also used to treat menstrual headache, which leads us to wonder whether POIS is related to estrogen?
OK guys, how do you like it? Be as free and open as you wish