Author Topic: Is POIS a version of CFS?  (Read 67440 times)

Progecitor

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Re: Is POIS a version of CFS?
« Reply #140 on: February 24, 2025, 10:34:38 PM »
As I stated yesterday:
technical jargon can alienate readers

Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!
The cause is probably a combination of autoimmunity and SASP leading to excessive oxidative stress and lipid peroxidation. Antioxidants, testosterone, NO and norepinephrine boosters, ERbeta, sigma-1, SIRT-1 and dopamine agonists, PDE4, PDE5 inhibitors and CD36 antagonists are effective.

carlo_francesco

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Re: Is POIS a version of CFS?
« Reply #141 on: February 25, 2025, 04:49:41 AM »
As I stated yesterday:
technical jargon can alienate readers

Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!

I can appreciate the effort you put into your posts, but this is a sulky attitude. In my everyday technical writing I also tend to overcomplicate things and go down endless rabbit holes of derivations. But most often brevity trumps endless elaborations, if you want to get a point across in scientific matters. As suggested earlier, in the future, you could restrict your posts to the key messages and put your intermediate reasonings into a text file attachment. This allows forum members to follow your arguments in-depth, if they wish.
« Last Edit: February 25, 2025, 09:51:34 AM by carlo_francesco »

demografx

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Re: Is POIS a version of CFS?
« Reply #142 on: February 25, 2025, 09:09:50 AM »

As I stated yesterday:
technical jargon can alienate readers

Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!

I can appreciat the effort you put into your posts, but this is a sulky attitude. In my everyday technical writing I also tend to overcomplicate things and go down endless rabbit holes of derivations. But most often brevity trumps endless elaborations, if you want to get a point across in scientific matters. As suggested earlier, in the future, you could restrict your posts to the key messages and put your intermediate reasonings into a text file attachment. This allows forum members to follow your arguments in-depth, if they wish.

Thank you, carlo_francesco.

There have been research studies that confirm the impact of technical jargon in forums with non-technical audiences:
   1.   Zimmermann & Jucks (2018): This study found that experts using less technical jargon in forums aimed at laypersons were perceived as more credible and trustworthy. Conversely, excessive jargon reduced perceived accommodation and trustworthiness when addressing non-expert audiences.
   2.   Galinsky’s Research (2022): This study suggested that jargon is often used to signal authority or status but can alienate audiences unfamiliar with the terms, reducing effective communication.
   3.   Cybercrime Forum Study (2023): Research on a cybercrime forum revealed that excessive use of jargon (argot) negatively correlated with user reputation, suggesting that simpler language fosters better engagement and trust.
These studies highlight the importance of tailoring language to the audience for effective communication in forums.
10 years of significant POIS-reduction, treatment consisting of weekly (52 weeks/year) testosterone self-injections.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

berlin1984

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Re: Is POIS a version of CFS?
« Reply #143 on: February 25, 2025, 09:39:49 AM »
FYI I took this post:
If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).

and pasted it into ChatGPT and asked it to dumb it down into easier language and summarize it to 3 sentences (twice):
Quote from: ChatGPT
The condition involves problems with how the body produces energy, often due to issues with the mitochondria. Some treatments for ME/CFS and long COVID focus on a protein called HIF-1a, which seems important for managing symptoms. The way energy shifts in the body during these conditions may explain the similarities between long COVID and POIS.

Maybe it's an option you put a tl;dr in front of your posts that contain an AI summary?

demografx

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Re: Is POIS a version of CFS?
« Reply #144 on: February 25, 2025, 04:31:09 PM »
FYI I took this post:

If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).
and pasted it into ChatGPT and asked it to dumb it down into easier language and summarize it to 3 sentences (twice):
Quote from: ChatGPT

The condition involves problems with how the body produces energy, often due to issues with the mitochondria. Some treatments for ME/CFS and long COVID focus on a protein called HIF-1a, which seems important for managing symptoms. The way energy shifts in the body during these conditions may explain the similarities between long COVID and POIS.
Maybe it's an option you put a tl;dr in front of your posts that contain an AI summary?

Brilliant, Berlin!!
« Last Edit: February 26, 2025, 06:32:55 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of weekly (52 weeks/year) testosterone self-injections.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.

demografx

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Re: Is POIS a version of CFS?
« Reply #145 on: February 28, 2025, 12:26:00 AM »

Maybe it's an option you [Progecitor] put a tl;dr in front of your posts that contain an AI summary?

Brilliant, Berlin!!
1.Berlin, I used tl;dr in front of this AI below twice
The question “what is life?” is complex and has been debated by philosophers, scientists, and thinkers across various disciplines. Here’s a concise overview:
Biological Perspective:
   •   Life is generally defined by characteristics such as growth, reproduction, functional activity, and continual change preceding death.
   •   It involves complex interactions at the molecular, cellular, and organismal levels.
Philosophical Perspective:
   •   Life can be seen as a journey of experiences, emotions, and consciousness.
   •   It often involves questions about purpose, meaning, and existence.
Cultural and Social Perspective:
   •   Life is shaped by relationships, culture, and societal norms.
   •   It encompasses personal growth, learning, and contributions to the world around us.
In summary, life is a multifaceted concept that can be understood through biological, philosophical, and cultural lenses.


2.…and I got this!
Life is a mix of biology, consciousness, and experiences.

3. using tl;dr only once
Life is a complex mix of biological processes, personal experiences, and social interactions that shape our existence and understanding of the world.

Amazing, Berlin! :)
« Last Edit: February 28, 2025, 12:17:32 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of weekly (52 weeks/year) testosterone self-injections.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.