Neurosteroids are involwed in POIS mechanism

[Hopeoneday]

While i resarching why benzodiazapines in small doses helped
me to surviwe In POIS atac, i dicovered that Neurosteroids are
wery potent positive GABAa receptors modulators.
(mainly by Allopregnanolone , androstanediol...)

So, syntesis of neurosteroids
in brain for exemple depend from pregnelone, progesterone,
testosterone by enzyme pathways...


List of neurosteroids.

https://en.wikipedia.org/wiki/List_of_neurosteroids



Allopregnanolone


https://en.wikipedia.org/wiki/Allopregnanolone

Allopregnanolone possesses a wide variety of effects, including,
in no particular order, antidepressant, anxiolytic, stress-reducing,
rewarding,[9] prosocial,[10] antiaggressive,[11] prosexual,
[10] sedative, pro-sleep,[12] cognitive, memory-impairment
....

Increased levels of allopregnanolone can produce paradoxical effects,
including negative mood, anxiety, irritability, and aggression.[17][18][19]

Scientists discover how neuroactive steroids dampen inflammatory
signaling in cells:
https://www.sciencedaily.com/releases/2019/02/190213142713.htm

I used to hawe seizures in POIS,
The conections here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252764/


Neurosteroid Biosynthesis Upregulation in PTSD:

https://www.intechopen.com/books/anxiety-disorders/
neurosteroid-biosynthesis-upregulation-a-novel-promising
-therapy-for-anxiety-disorders-and-ptsd


Tolernace to allopregnanolone in chronic acute stress:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031054/

Neurosteroid s’effects and mechanisms for social,
cognitive, emotional, and physical functions:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898141/

[b_jim]

I think you are close to the truth and  GABA receptors is a key of the mystery.

[swell]

I think you are close to the truth and Cholesterol the pre-cursor to Neurosteroids may be playing a key role in POIS

[Nas]

Excellent post HOD, neurosteroids are definitely a strong candidate. Maybe that's why dexamethasone works for me.

[b_jim]

After 5 ejaculations, my bloodtest showed :
-normal total testosterone
- normal but low limit free testosterone
- DHEAs too high

An old bloodtest (15 years?) showed low total cholesterol out of Pois.

DHEAs too high would give me "male" symptoms : muscles, hairy strong voice... that I doen't have.

[Muon]

My total cholesterol has always been low. You can also find members on this forum who have high levels which makes a potential link between POIS and cholesterol questionable. Are there any tests available that can verify this theory? What neurosteroid could be tested?

[Nas]

I also like to add, are neurosteroids endogenous in the brain or do they affect the brain when produced ( outside of the nervous system )?

[demografx]

Muon, FWIW, I’ve been on cholesterol meds (rosuvastatin calcium aka Crestor) since open heart surgery.

[Nas]

One contradiction with this theory is that both inhibitory and excitatory neurosteroids have benefits; the former is  anti-depressant, anti-anxiety, pro-social, pro-sleep, etc. The latter is pro-memory and pro-cognitive. This can not fit into POIS, since the majority of POISers experience both cognitive and psychological symptoms, even those who have agitation symptoms also report cognitive issues. I don't know how you can amend this contradiction since you can't have only the negative effects without the positive effects.