Stress

[traderwithpois]

Stress

[Green]

I'm down with depression, stress and POIS have been interlinked for me. Even when out of POIS I constantly think about things, I've had generalised anxiety disorder since my early teens, large part health anxiety.

[Vincent M]

I have social anxiety pretty bad and last semester at college I had a constant burning in my chest from all the anxiety. Felt like there was literally a ball of acid in my chest at all times.

I believe this anxiety worsened my POIS symptoms.

[Samir]

I work almost 24x7, just stopping to sleep and eat.  An average day for me is 10-12hrs with as many as 20hrs in a 48hr time period on the weekends.

[BoneBroth]

Stress and homonal imbalances goes hand in hand

[Muon]

Animus, did you experience any stress or were you in a stressful situation just prior to your development of POIS symptoms?

Hi Muon,
Great question... thank you for asking. Short answer: YES.  Lots of stress at the time when I developed POIS.
I was stressed out with life in New York City, and wanting to leave.  Also intense physical stress I think. What really triggered it for me, was when I took some herbal "male enhancement pills". They were designed to give more powerful erections, and more volume ejaculations. They also caused my testicles to grow twice their size, seriously.  They had a very bad effect on me for some reason.

So, as to your question, I don't know if you mean physical or mental stress. But at the time, I certainly had both.

Dr. Theoharides:

" Therefore, any type of stress by definition is likely to stimulate the mast cells directly or make them more responsive either to new triggers or whatever triggers a patient might have had to begin with."

"We published a paper a long time ago that stress meaning CRH we add CRH to human mast cells they become much more responsive to Mercury, for instance, okay. And this is an area that just not being discussed, that the mast cells must have some threshold that is being reset. Because I have so many patients who basically say, "Something happened, and all of a sudden I'm allergic or I respond to everything" Ref

Stress ---> could made his genitourinary mast cells responsive to constituents of semen.

They also caused my testicles to grow twice their size, seriously.  They had a very bad effect on me for some reason.

Could be swelling and could be a sign of mast cell activation (MRGPRX2 is a key player in drug hypersensitivities), plus it may be an additional trigger to stress (on top of his true allergies which are IgE mediated triggers):

"Combination of triggers is more important than individual ones as they can lower the stimulation threshold of mast cells and 'prime' them for additional triggers." Ref

Castration prevents direct contact between the constituents of semen and the primed mast cells of the genitourinary system.

[Journey]

Animus, did you experience any stress or were you in a stressful situation just prior to your development of POIS symptoms?

Hi Muon,
Great question... thank you for asking. Short answer: YES.  Lots of stress at the time when I developed POIS.
I was stressed out with life in New York City, and wanting to leave.  Also intense physical stress I think. What really triggered it for me, was when I took some herbal "male enhancement pills". They were designed to give more powerful erections, and more volume ejaculations. They also caused my testicles to grow twice their size, seriously.  They had a very bad effect on me for some reason.

So, as to your question, I don't know if you mean physical or mental stress. But at the time, I certainly had both.

Dr. Theoharides:

" Therefore, any type of stress by definition is likely to stimulate the mast cells directly or make them more responsive either to new triggers or whatever triggers a patient might have had to begin with."

"We published a paper a long time ago that stress meaning CRH we add CRH to human mast cells they become much more responsive to Mercury, for instance, okay. And this is an area that just not being discussed, that the mast cells must have some threshold that is being reset. Because I have so many patients who basically say, "Something happened, and all of a sudden I'm allergic or I respond to everything" Ref

Stress ---> could made his genitourinary mast cells responsive to constituents of semen.

They also caused my testicles to grow twice their size, seriously.  They had a very bad effect on me for some reason.

Could be swelling and could be a sign of mast cell activation (MRGPRX2 is a key player in drug hypersensitivities), plus it may be an additional trigger to stress (on top of his true allergies which are IgE mediated triggers):

"Combination of triggers is more important than individual ones as they can lower the stimulation threshold of mast cells and 'prime' them for additional triggers." Ref

Castration prevents direct contact between the constituents of semen and the primed mast cells of the genitourinary system.

How 2 stop mastcell orgasm reaction? If POIS=MCAS why while ill POIS disappeared?