New Member Intro

[certainlypois2]

I found a post on NakedScientists where he said he also had a crash on day 4 and 5 when using weak antihistamines. At least I think that's what he means. It's hard to understand the sentence.

Hello everyone,
I am happy2.  I found the cure for POIS at Christmas time.  I am now 100% POIS free.  B Jim, Daveman, or whoever, e-mail me, and I will let you know how I did it.  I posted years ago with a severe case of POIS.  I suffered for almost 20 years.  3 1/2 years ago I went to a urologist.  He said he had never heard of this before.  However, he told me to get on an anti-histamine, which I did.  30 days later, after being on Claritin daily I orgasmed.  I immediately got out of bed and popped 2 benadryls and as I reported 3 1/2 years back, this reduced POIS symptoms by 95%.  I went back to same urologist 3 years later, this last July.  He told me to get on Zyrtec because this was more powerful of an anti-histamine than Claritin.  I experimented with Zyrtec next POIS session on days 1, 2, and 3.  Usually with physical or mental exertion on any POIS day for me has caused fatigue, or crash days, the following days after POIS, days 4 and 5.  This time was different, however.  I had no crash days on 4 and 5.  So, I started taking both Claritin and Zyrtec together, daily.  Two months later, I orgasmed, popped the usual 2 benadryls, and waited, 30 seconds, 1 minute, and nothing.  Mind did not fog over for the first time in 20 years following an orgasm.  This occurred at Christmas time, 2015.  I experimented for the next 4 weeks, orgasming 12 times.  Every time was the same result, NO POIS.  Thank God I found this cure.  I tried one benadryl instead of two, and it did not give the same result.  So, to recap, one Claritin and one Zyrtec daily, and exactly 2 benadryls immediately, within 20 seconds or so following orgasm.  NO POIS.  Thanks to the people on this site that gave me so much information about POIS.  I would have never known what it was except for this site.  Like I said, moderators, feel free to contact me.  Thanks to all.

So I went to my doctor and got a prescription for Hydroxyzine (Atarax) on advice of someone on reddit who says a single dose of 50mg before O relieves him of POIS. The doctor says this is the strongest antihistamine available. I will experiment with a single dose because I don't want to take daily antihistamines like Happy2 if I can avoid it. But if I continue to crash on day 4 and 5 I may have to take a weak antihistamine daily plus the Hydroxyzine before O.

It crosses the blood brain barrier. There might not be a need the benadryl.

[OpiesDad]

Hi guys -- just an update.  I'm having to start over on the elimination, because I got crossed up on my medications and proceeded to have a very bad POIS event that lasted 7+ days. 

More color -- I got "cocky" and played with a medication (dapoxetine) that is supposed to help with premature E (something that started happening after POIS emerged last year).  The medication "worked" in my experiment but also left me completely POIS'd.  IN fact it made me wonder whether the duration of the sexual arousal whichw as 5x longer than would be normal for me now somehow made the POIS worse.

Anyways, interested in hearing how the attarax goes, meanwhile I will try to get back to testing.

[drop247]

To my surprise Atarax didn't work. I may have screwed up the experiment though because I started sexy times early before taking it and had significant precum. Then I took the Atarax and waited an hour before finishing. So I was exposed to semenial fluid for a long time without protection. I should try the experiment again soon once I'm out of POIS. I'm disheartened though. I'm starting to wonder if it was the pseudoephedrine in the Allegra-D that works well due to vasoconstriction.

[Muon]

I'm starting to wonder if it was the pseudoephedrine in the Allegra-D that works well due to vasoconstriction.

Someone should try pure pseudoephedrine and time it with POIS. It isn't available here so I have never tried it. We had a discussion about it on this board somewhere.

[b_jim]

We know POIS hits much more men than women.
So something is specific to men.

Women orgasm is linked to oxcitocyne release while men orgasm is linked to vasopressin release.

We know vasopressin has vasocontriction effect and it causes prostaglandin (=inflammation) release.

So the question is : too much vasopressin  ? Not enough ? And where ?

[Muon]

Yes vasopressin is interesting. I have seen some folks here with elevated Aldosterone which can lead to higher Angiotensin II which stimulates AVP production and drives up sympathetic activity. The medicine Losartan is able to block this, this is something I wanted to try for a long time, it's used for POTS as well, but they won't give it to me when I ask for it. Same goes for pyridostigmine to lower heart rate a bit by other means than blocking beta1 receptors.

[demografx]

I always thought vasopressin was interesting.

[Nas]

We know POIS hits much more men than women.
So something is specific to men.

Women orgasm is linked to oxcitocyne release while men orgasm is linked to vasopressin release.

We know vasopressin has vasocontriction effect and it causes prostaglandin (=inflammation) release.

So the question is : too much vasopressin  ? Not enough ? And where ?

B_jim both men and women release oxytocin after sex. I think what you're looking for is the refractory period. Women do not have a refractory period after an orgasm that's why they can go for round two while we don't. It also can be related to the plumit of dopamine we suffer from causing us low motivation and all the brain issues we suffer from.

[demografx]

Last time I read about it, I think oxytocin can be purchased in Europe as a nasal spray. Now also on Amazon? Supposedly it helps many cognitive areas, e.g., overcoming shyness. Please be very cautious with it. See your doctor.