The Role of Histamine H3 in POIS's Cognitive Symptoms

[Nas]

POIS is a tricky illness and one with multiple symptoms that can be different from on POISer to another. One theory suggests a huge similarity between Mast Cell Activation Syndrome ( MCAS ) and POIS. Another theory supposes an auto-immune reaction to seminal fluid as proposed by Waldinger (1). Though it is much more likely that POIS can be a case of Mast Cell Activation Disorder ( MCAD ) through auto-immune signaling of IgG anti-bodies. (2)

A huge part of the debilitating effects of POIS symptoms are those that are related to Central Nervous System ( CNS ). One of them are the Cognitive cascade of symptoms that involve debilitating Cognitive an Social problems. These problems are supposed to be caused by the inflammation that occurs in the CNS. Typically suggested treatments for such problem are anti-histamines or NSAID. The later treatment is inconsistent and personally never worked for me. The former is also inconstant and it also never worked for me. In both cases it might have worked for some people but not for me, nor for others. This is strikingly similar to the case of MCAS.

Thus I suggest an investigation of the role of Histamine H3 receptors which are primarily located in the CNS; Which are, unlike the H1 receptor, possess an anti-inflammatory effect (3). Yet, they also possess an inhibitory role of many neurotransmitters such as ( Dopamine, GABA, acetylecholine, neuradrenaline, histamine, serotonin, etc.) (4). It could be that H3 histamine is released during neuroinflammation to counter act the release of histamine H1 which can cause damage to these neurons, but by its release it inhibits the function of many neurotransmitters and thus it inhibits many functions in the brain.

A way to investigate this theory is to try Histamine H3 receptor antagonists. Such as Betahistine, or Ciproxifan and Wakix (if available to you) under professional medical supervision. I don't have access to these drugs personally but maybe it'll help folks who do have access to it.

Best of luck to you all.

[FernandoPOIS]

I agree NAS
But I still like my theory

1. Stress/depression = decrease in serotonin, noradrenaline, dopamine, gaba and testosterone.
2. Chronic inflammatory condition (spine, intestine, nerves, muscles, uretra) = depletion of acetylcholine stores.
3. Low blood pressure or dysautonomia (due to the body type I saw in Facebook photos) = depletion of acetylcholine stores.
4. Orgasm: requirement of the neurotransmitters described above for excitement-orgasm-reorganization after orgasm.
5. Consequence: Anaphylaxis because the body understands as an aggression the event of orgasm. There were not enough neurotransmitters at the time of orgasm. Vagus nerves working poorly do not perform the job properly.

[Nas]

I agree NAS
But I still like my theory

1. Stress/depression = decrease in serotonin, noradrenaline, dopamine, gaba and testosterone.
2. Chronic inflammatory condition (spine, intestine, nerves, muscles, uretra) = depletion of acetylcholine stores.
3. Low blood pressure or dysautonomia (due to the body type I saw in Facebook photos) = depletion of acetylcholine stores.
4. Orgasm: requirement of the neurotransmitters described above for excitement-orgasm-reorganization after orgasm.
5. Consequence: Anaphylaxis because the body understands as an aggression the event of orgasm. There were not enough neurotransmitters at the time of orgasm. Vagus nerves working poorly do not perform the job properly.

Well your theory is a bit hard to prove, and mine is as simple as taking a drug. Mine focuses of the work already done by Waldinger and his suggestions.
Anyways, no one really knows what POIS is until it is observed scientifically. Who knows if what we theories is true or not.

[FernandoPOIS]

I have been reading about histamine in the last few days and I believe there is a very direct relationship between POIS and histamine with some considerations related to my theory that shows a problem in the work of the vagus nerve. For example:
The vagus nerve is responsible for the immune response and it is a part responsible for the release of histamine. If there is a problem in the vagus nerve, there will probably be problems in controlling histamine.
Histamine is responsible for orgasm. People with low histamine have greater difficulty in achieving orgasm. A member here of the forum reported that the antidepressant citalopram in dose of 40 mg made him heal of the POIS. We know that this antidepressant besides inhibiting the reuptake of serotonin is also a histamine inhibitor.
If we look at the symptoms of POIS we see that there is release of histamine and prostaglandins. After orgasm we have allergic symptoms and body aches. Then comes the individual problem of each one. In my case I have few allergic problems and what hurts me most is the muscle pain.
Hypotonia and cognitive problems seem to be common to all members. I believe this is due to the exaggerated release of allergic and inflammatory mediators that deplete the stores of acetylcholine.
To summarize I believe that an antidepressant with a function of inhibiting histamine as is the case of citalopram can help prevent POIS. And as we all know the antihistamines after orgasm help as well.
But there is the question of prostaglandins (pain mediators). For this problem it would be interesting an anti depressant that works by decreasing the painful sensitivity of the muscles. I believe the best in this case are duloxetine and venlaflaxin. And after the orgasm still have to be made the use of analgesics or anti-inflammatory.
These attempts are valid but they can not be the only way to combat POIS because if we do not treat the inflammation or allergy that exists in each one suffering from the problem, the attack is not being done in the cause of the problem.
There is still the issue of neurotransmitters related to depression and anxiety such as serotonin, dopamine, noradrenaline and gaba.
So I propose:
 - Abstinence (going without orgasm!)
 - Correction of the vagus nerve (muscle relaxation, postural correction, physiotherapy for strengthening the spine and adjacent muscles)
 - Stress management

Once you have a body without inflammation and well strengthened you may have orgasms again. But I believe you should always try to stay as good as abstinence.
It's a great challenge!

[demografx]

Fernando from Brazil,

Thanks for keeping the vagus nerve theory alive!