Gather and Post Here Your Medical Tests Results - Discussion Thread

[nanna1]

...There seems to be a pattern emerging in the Medical Data/test thread show immunodeficiency in many of us POISers.

A few patterns in the data:
--4 of us have low neutrophil counts (nanna1, quotz, BluesBrother, certainlypois2).
--3 of us show normal neutrophil levels (Muon, Muon's brother, Nas).
--1 of us show low monocyte levels (quotz)
--1 of us show low Natural Killer cell (NK cells) levels (muon)
--2 of us show low lymphocyte levels (muon, fernab)
--1 of us show lymphocytes do not increase in response to lung infection (aswinpras06)

  I am only showing data of people who self-report, but Hopeoneday has also found several cases of neutropenia in POISers posted elsewhere. Immunodeficiency diseases are rare (low prevalence, post), so this seems very interesting. Most of the data is on Complete Blood Counts (CBC, neutrophils), but I think Muon's low NK cell levels is the most interesting result so far. This is because NK cells are the primary virus killers of the immune system. These immune deficiencies are all associated with the innate immune system. The innate immune cells (monocytes, neutrophils, NK cells) are the first responders to a harmful event (infection, cancer, poison, etc...). If the innate immune system fails, then the adaptive immune system (T cells, B cells, etc...) takes over and tries to control the harmful event.

  I mention all this because low immunoglobulin levels are sometimes used to measure immunodeficiency diseases. But this is usually done using the IgG subclasses (IgG1, IgG2, IgG3, IgG4). Kurtosis and Muon have written a few good post on immunoglobulins...
Immunoglobulin are mostly related to the innate and adaptive immune systems...
A test that measures NK, T and B cells would probably be... informative (Lymphocyte Subset Panel Test).

There is not enough data to confirm or disprove that POIS is a type of immunodeficiency disease. But test like this that measure Natural Killer cells, T lymphocytes and B lymphocytes can help (Lymphocyte Subset Panel Test). If you cannot get one test that has all three cell counts, you can order them individually. A total lymphocyte count will not reveal a NK cell deficiency because NK deficiencies are compensated by T cell over-expression. Low total lymphocyte levels probably means multiple cell types are deficient.

Individual Lymphocyte test:
CD56+ or CD16+ = NK cell test
CD4+ (helper) and CD8+ (suppressor) = T cell test also T-Lymphocyte Helper/Suppressor Profile
CD19+ = B cell test

[fernab]

Hi all,

As I told you last january 8th I have visited a specialist. I'm sorry I could not write you before, but I've had a lot of personal difficulties

I told him my symptoms. And which is my trigger. Pressure by the pelvic área, buttocks and lumbar area.

For the moment, I said nothing about POIS. To preventing him thinking of something other than MCAS.

As a POIS sufferer I know that also any emision (seminal or preseminal) is a trigger for my symptoms. But as I explained I prefered to tell nothing about POIS.

In general, of all the set of symptoms I told him. He told me that some of them where not typical to MCAS.

But anyway, he told me that it could be due to a MCAS. So he thinks that maybe I am an MCAS sufferer.

So, he decided I do a genetic test in first place. It called something like ‘mutation in SP’ or ‘Mutation Kit study’. This genetic test will be driven by hematology ( in the hospital I went to see this specialist ).

I have to wait until hematology calls me back and they will give me then a date for blood extraction. One month after the extraction we will have the genetic result. If it turns out positive, he explained me that the probability of being a MCAS sufferer increases considerabily.

In parallel to the genetic study, he has also asked me to take two histamine inhibitors. one for H1 receptors (bilastine 20 mg/day) and another for H2 receptors (Ranitidine 150mg/day). Besides the disodic cromoglycate (200mg/8hours). and the anti-inflammatory etoricoxib (which I've been noticing for a long time It helps me a lot, 60mg whenever I feel I need it, once a day).

Here below, I add some personal reflections:

MCAS has a lot of similarities with POIS:

1.- As for POIS, there are no two patients alike. Symptoms and treatment should be unique per patient.

2.- MCAS has many different Activation triggers.

3.- Could POIS be a form of MCAS in which the trigger is any emision (seminal or preseminal)?

Will continue updating.

[fernab]

By the way, my IgG levels are normal.

[fernab]

Sorry. And IgM, also. Normal.

In my last blood test, curiously, my lymphocyte level is a bit low : 1.09 10E3/microL (normal range 1.2 - 4.0).

[Vandemolen]

Sorry. And IgM, also. Normal.

In my last blood test, curiously, my lymphocyte level is a bit low : 1.09 10E3/microL (normal range 1.2 - 4.0).

Great Fernab. Keep us updated about your MCAS doctor. There are MCAS-patients who have abnormal IgG, IgA or IgM levels.

[Nas]

MCAS has a lot of similarities with POIS:

1.- As for POIS, there are no two patients alike. Symptoms and treatment should be unique per patient.

2.- MCAS has many different Activation triggers.

3.- Could POIS be a form of MCAS in which the trigger is any emision (seminal or preseminal)?

Will continue updating.

This is pretty much what I theorize, but the failure or the MCAS regiment to have any profound effect on my POIS is making me more skeptical. I very much appreciate what you are doing Fernab because you're pretty much working on figuring out whether Mast Cells are involved or not. But I think I'm moving towards trying to fix a hormonal issue, since nothing really is working for me when it comes to anti-inflammatory treatment, besides dexamethason.

[Limejuice]

My lymphocyte levels are normal along with most other immune response markers. However, a couple are elevated such as basophil count  and % which could indicate chronic inflammation (as would be the case with leaky gut and POIS which I have). My platelet count is high but results show platelet clumps were observed which would alter results.

[Muon]

Thanks for the update Fernab. I'm also interested in T-regulatory cells because they play a role in immunological tolerance in particular self/non-self discrimination.

https://en.wikipedia.org/wiki/Regulatory_T_cell
https://en.wikipedia.org/wiki/Immune_tolerance
https://en.wikipedia.org/wiki/Central_tolerance
https://en.wikipedia.org/wiki/Peripheral_tolerance

[nanna1]

...one way of interpreting Habibou's neurotransmitter test is that he has reduced functioning of his Aldehyde dehydrogenase (ALDH) enzyme (see dopamine degradation pathway, DOPAC, HVA). I would rule out monoamine oxidase (MAO) dysfunction because his serotonin and 5HIAA are normal. I would also rule out catechol-O-methyltransferase (COMT) dysfunction because his DOPAC levels are low and his MHPG is normal. DOPAC does not depend on COMT (diagram1) but MHPG does diagram2). The diagram below shows the enzymes responsible for the 3-Methoxy-4-hydroxyphenylglycol (MHPG) and Vanillylmandelic acid (VMA) parameters in his urine test:

[Hopeoneday]

This is the perfect exapmle that this member actualy cant see that this could
be (I think that it is) couse of his pois.

I think that here is key of pois in some of us, genetics test results of curisocaracter.
https://poiscenter.com/forums/index.php?topic=2728.msg24633#msg24633


So here we see, vitamin D problem(GENETIC MUTATION)
For this reason, having MTHFR SNPs that cause undermethylation and COMT SNPs that result in lower COMT are a BAD COMBINATION.
And this-
Catechol-O-Methyltransferase (COMT) is one of several enzymes that degrade dopamine, epinephrine, and norepinephrine.

So acording to this , genetics mutations a lot of stuff in body can go wrong

    MTHFR A1298C - heterozygous
    VDR bsm - homozygous
    COMT V158M - heterozygous
    COMT H62H - heterozygous
    MTRR A66G - heterozygous


This couse a low vit D
We see that LH hormone can be disturbed and this could be explanation
of LOW T in big mayority of poisers.
Degrade dopamine, epinephrine, and norepinephrine feilure.
Wery senzitiwe, toxic, on mercury exposure (note in mans only).

All expleined here:
https://selfhacked.com/blog/worrier-warrior-explaining-rs4680comt-v158m-gene/

[Nas]

This is the perfect exapmle that this member actualy cant see that this could
be (I think that it is) couse of his pois.

I think that here is key of pois in some of us, genetics test results of curisocaracter.
https://poiscenter.com/forums/index.php?topic=2728.msg24633#msg24633


So here we see, vitamin D problem(GENETIC MUTATION)
For this reason, having MTHFR SNPs that cause undermethylation and COMT SNPs that result in lower COMT are a BAD COMBINATION.
And this-
Catechol-O-Methyltransferase (COMT) is one of several enzymes that degrade dopamine, epinephrine, and norepinephrine.

So acording to this , genetics mutations a lot of stuff in body can go wrong

    MTHFR A1298C - heterozygous
    VDR bsm - homozygous
    COMT V158M - heterozygous
    COMT H62H - heterozygous
    MTRR A66G - heterozygous


This couse a low vit D
We see that LH hormone can be disturbed and this could be explanation
of LOW T in big mayority of poisers.
Degrade dopamine, epinephrine, and norepinephrine feilure.
Wery senzitiwe, toxic, on mercury exposure (note in mans only).

All expleined here:
https://selfhacked.com/blog/worrier-warrior-explaining-rs4680comt-v158m-gene/

Wait so you have a MTHFR SNP mutation?

[Hopeoneday]

Nas, i suspect that genetics factors are inwolwed in big here.

Catecholamines are like you supouse definitly inwolwed here.
I didnt tested, because unfortinutly , i was born where i am born , and because of
that , i cant do a big mayority of tests wich i wish to do.
Something similar to Iran in your case.

As you can see from genetics test of this member, what cascade of feilures
that can lead, it can lead streight to pois when you read deaper.

[Nas]

Nas, i suspect that genetics factors are inwolwed in big here.

Catecholamines are like you supouse definitly inwolwed here.
I didnt tested, because unfortinutly , i was born where i am born , and because of
that , i cant do a big mayority of tests wich i wish to do.
Something similar to Iran in your case.

As you can see from genetics test of this member, what cascade of feilures
that can lead, it can lead streight to pois when you read deaper.

I'm from Iraq btw, but I'm still confused, who are these tests for? Is it for a nother POIS sufferer or just a guy who has MTHFR mutation?

[Hopeoneday]

Yes Iraq... i posted link of curioscharacter post about his genetics test results.

It is on 4rth line in my post from up to the botom.

[Nas]

Yes Iraq... i posted link of curioscharacter post about his genetics test results.

It is on 4rth line in my post from up to the botom.

Hmmmm, I guess this is potentially huge.

[Muon]

Could abnormalities in catecholamine metabolism alter adrenoceptor densities? Could this lead to premature ejaculation?

[Nas]

This is the perfect exapmle that this member actualy cant see that this could
be (I think that it is) couse of his pois.

I think that here is key of pois in some of us, genetics test results of curisocaracter.
https://poiscenter.com/forums/index.php?topic=2728.msg24633#msg24633


So here we see, vitamin D problem(GENETIC MUTATION)
For this reason, having MTHFR SNPs that cause undermethylation and COMT SNPs that result in lower COMT are a BAD COMBINATION.
And this-
Catechol-O-Methyltransferase (COMT) is one of several enzymes that degrade dopamine, epinephrine, and norepinephrine.

So acording to this , genetics mutations a lot of stuff in body can go wrong

    MTHFR A1298C - heterozygous
    VDR bsm - homozygous
    COMT V158M - heterozygous
    COMT H62H - heterozygous
    MTRR A66G - heterozygous


This couse a low vit D
We see that LH hormone can be disturbed and this could be explanation
of LOW T in big mayority of poisers.
Degrade dopamine, epinephrine, and norepinephrine feilure.
Wery senzitiwe, toxic, on mercury exposure (note in mans only).

All expleined here:
https://selfhacked.com/blog/worrier-warrior-explaining-rs4680comt-v158m-gene/

Wait I'm confused, does COMT SNP cause lower or higher amounts of catecholamines? From what I read, it should cause excess of these neurotransmitters which are quite the opposite of the usual cognitive symptoms we suffer from?

[fernab]

They have taken a while to call me back. But finally I have an appointment for blood extraction to do the genetic test.

Next thursday (7th February) they hopefully will take my blood sample. And a month later (8th March), will know the result.

I'll tell you the result of this genetic test.

[demografx]

Thank you, fernab!

[Vandemolen]

Bloodtest Vandemolen (I combined a few bloodtest in the last years because not all things were tested in 1 blood test)

Hemotology
ESR: 3. Reference range (RR)0-15
Hemaglobin: 9.8. RR: 8.5-11
Hematocrit: 0.40. RR: 0.40-0.50
Mean Corpuscular Volume: 84. RR: 80-100
Erythocytes: 4.89. RR: 4.50-5.50
Trombocytes: 6.0. RR: 6.0
Leucocytes: 5.6. RR: 4.0-10.0
Neutrophils: 2.95. RR: 2.0-7.0
Basophilic granulocytes: 0.05. RR: 0-0.20
Eosinophilic granuloctyes: 0.15. RR: 0.00-0.45
Lymphocytes: 2.01. RR: 0.50-4.50
Moncytes: 0.41. RR: 0-0.80.
Ferritin: 54. RR: 25-250
Amalyse 92. RR: 0-99

Clininal Chemie
Urea: 3.5 (in 2016). RR: 2.5-6.5
Creatinine: 85. RR: 64-104
eGFR (MDRD): higher than 60. RR: higher than 60
eGFR (CKD-EPI): higher than 90. RR: higher than 90
Natrium: 141. RR: 135-145
Calcium: 2.59. RR: 2.15-2.65
Magnesium: 0.95 (in 2016). RR: 0.70-1.00
Uric acid: 0.37. RR: 0.20-0.38
ASAT: 29. RR: 0-34
ALAT: 26. RR: 0-44
Alkaline Phosphoatase: 56. RR: 40-120
gammaGT: 35. RR: 0-54
Tryptase: 4.6. RR: 0-11.4
Triglycerides: 2.4 (in 2016). RR: 0-2.0
Glucose: 5 (in 2016). RR: 4-6
Vitamin B12: 525. RR: 130-700
Methylmalonic serum: 221. RR: less than 350
Homocysteine: 9. RR: 0-15
Folic acid: 29. RR: 6-39
Vitamin D (25-OH): 173. RR: higher than 50
Iron: 13. RR: 14-30
Transferrin: 2.3. RR: 2-4
Cholesterol: 7.21. RR: 2.50-6.50
LDL cholesterol: 3.6. RR: less than 2.5
HDL cholesterol: 1.0. RR: less than 1.0

Endocrinology
TSH: 8.1 RR: 0.55-4.8
Free T4: 17.5. RR: 10-26
Thyriod Peroxidase antibodies: 25. RR: less than 50
Cortisol: 0.19. RR: 0.03
Testosterone: 9.6 (in 2016). RR: 10-30
Free testosterone: 378 (in 2011). RR: 174-729
SHBG: 12 (in 2011). RR: 13-71
DHEA-S: 7.0. RR: 2.6-14
PTH: 1.6. RR: 1.6-6.8
PSA: 2.3 (in 2016). RR: 0-2.0

Immonology
C-reactive protein: 1. RR: 0-10
IgA: 1.22. RR: 0.70-4.00
iGe: 64 (in 2015). RR: 1-90
IgM: 0.26. RR: 0.40-2.30
IgG: 10.0. RR: 7.0-16.0
t-TransGlut IgA: less than 1 (in 2011). RR: 0-5
Prolactin: 0.29 (in 2011). RR: 0-0.32
Progestrone: 1.8 (in 2010). RR: 0.7-4.3
HCG + beta: less than 1 (in 2011). RR: 0-1
ANA-titer: 1.160. RR: less than 1.80
ENA-screening: neg. RR: neg
Ds-DNA as: less than 10. RR: 0-35

Did some new blood tests. Most important is that my ANA-titer is too high. I do not know what this means for POIS. But it is for sure that on immunology there is something wrong. Althought also healthy people can have too high ANA-titer.