I have developed my pre-pack in the 4 to 6 months after having found this forum. Obviously I have tried niacin, because of so many members here having good results with it. Some early versions of my pre-pack included niacin. It was quite positive has a result, but no better than other pre-pack versions without niacin, so considering the flush, and considering I had to time with meal, it was added complexity that other pre-pack versions did not have, so i let go of niacin.
Also, afterward, my current pre-pack was developed around my hypothesis on POIS pathophysiology, so, as I made research on the IDO and TDO enzymes, and their immune upregulation leading to excitotoxicity, and the production of pro-inflammatory cytokines, and the tryptophane use, and so on, I have chosen my pre-pack elements accordingly, and searched for natural products to act as TDO inhibitors, IDO inhibitors, NMDA receptors inhibitors to block excitotoxicity, antioxidants against pro-inflammatory cytokines, and so on.
B-complex may have been of help, but no part of my hypothesis lead me to include them in my pre-pack. And, once I got to a pre-pack composition that was consistently efficient, after 6 months of "development" and trials, I just stopped at that and keep on with the good results ( and it is still effective after over 2 years).
B-complex could have a role in the days after release when my pre-pack has not blocked 100% of symptoms. I have used them before, they give me a good boost in energy, but only if using them from time to time ( for me, when used daily, they stop to work after a few weeks). But, nowadays, I have turned to green smoothies and highly healthy diet to get all the viatamins I need, even what's not even studied by science ( I trust nature itself on that, in bringing through good food allthe necessary nutriments .... and nutrition scinece confirms that )
About your prevention plan, it's hard to tell if things could be the same for you, but abstaining during your "phantom phase" of POIS, when blocked with your pre-pack, seems to be a safe approach for sure, when you really want to stay away form any POIS symptoms.
It is sometime hard to keep that much discipline in a relationship context, but I have discussed this with my spouse, and she knows about the fact that I need at least 4 days between release - it is important to set things clear with your spouse and agree, and "collaborate" in order to maintain optimal "timing" of releases. She do not like at all the "anxious madman" I become when in POIS, and appreciate my 'normal' self, so she easily agrees with this way of doing things.
