Author Topic: New ideas about POIS and review of excitotoxicity  (Read 30029 times)

Quantum

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Re: New ideas about POIS and review of excitotoxicity
« Reply #20 on: April 18, 2017, 07:34:43 AM »
Hi TTP,

It sounds promising for you.

Your story with Parmesan reminded me of a "recipe" I had written about how to have a severe POIS cycle ( I have found it back at the bottom of this post: http://poiscenter.com/forums/index.php?topic=1235.msg15572#msg15572 ):

"So, a good recipe for a hellish POIS cycle would be to take, at least 2 hours before O, a lot of sodas and junk sweets ( as HFCS sources), along with aspartame and MSG, and also some BCAA supplement as well if you are really masochist.  Add some lactose or gluten, if your digestive tract is irritated by them, or anything else that will help produce pro-inflammatory cytokines in the guts - this will increase the madness of your POIS. And, of course, avoid anything beneficial, including niacin, tryptophan sources, 5-HTP, curcumin, or any antioxidant.  Be sure to be stressed and worried, so your cortisol is high and turns your TDO liver enzyme in overactive mode, depleting your Trp still more. Anybody want to try this recipe for the worst POIS ever ?   O_o    Sincerely, I hope not ! ! !

A healthy diet is obviously leading to.....  a better health :)"


It is surprising how much what we eat can influence our immune reactions.   


Keep us updated on your experiments. 



I have a question about one of your supplement,  What source of luteolin are you using ?   It is not easy to find a good sources of it.  I am using artichoke and rosemary as luteolin source, currently.
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #21 on: April 18, 2017, 10:55:32 PM »
Quantum,

Yeah the gluten in the pasta and glutamate in Parmesan cheese is one of the worst things you could eat during POIS, I just love it so much I've kind of ignored it until now, now that I've really seen the effect it has on me I'm not going near it during POIS.

For Luteolin it is hard to find, which is unfortunate because it might be even better than Quercetin.  I used to order Luteolin, Quercetin, Bromelain and Olive Leaf Extract from Swanson vitamins, but I just ordered NeuroProtek because it essentially combines all of these into a few pills. 

Spartak

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Re: New ideas about POIS and review of excitotoxicity
« Reply #22 on: April 20, 2017, 10:58:35 AM »
Hi Trust,

Interesting to see that you mentioned parmessan, I can say that cheese is pois safe food for me, same as milk,
I saw that some POIS-ers can't handle them, but judging by verious relief treatments which work on various members and fact that there are various types of POIS, it seems that every intolerance or relief method are pretty subjective.
I can't handle magnesium suplementation, while some have relief with it. Seems the same with gluten, I can eat gluten as much as I want, no effect on my POIS, but I can't handle sugars.

Take care,
Spartak
« Last Edit: April 20, 2017, 11:02:04 AM by Spartak »
no sugar diet helps me a tiny bit, also makes my mind much calmer in general. Sugar is definitely something my body does not handle well. Also I noticed that other inflammations like a hangover are better since I quit sugar. I avoid sweet fruits as well.

Quantum

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Re: New ideas about POIS and review of excitotoxicity
« Reply #23 on: April 21, 2017, 12:36:43 PM »
Quantum,

Yeah the gluten in the pasta and glutamate in Parmesan cheese is one of the worst things you could eat during POIS, I just love it so much I've kind of ignored it until now, now that I've really seen the effect it has on me I'm not going near it during POIS.

For Luteolin it is hard to find, which is unfortunate because it might be even better than Quercetin.  I used to order Luteolin, Quercetin, Bromelain and Olive Leaf Extract from Swanson vitamins, but I just ordered NeuroProtek because it essentially combines all of these into a few pills.

Thanks TTP for the information about the Swanson preparation of luteolin.   Luteolin is contained in parsley, artichoke leaves, celery, peppers, olive oil, rosemary, olive leaf extract, lemons, peppermint, sage, thyme and other foods, but it is harder to know how much you get through these sources, exactly.

At least a couple of member reported they had used NeuroProtek ( I think Kurtosis did, and had positive results with it). Let us know what it will do for you.

You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

VSmasher

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Re: New ideas about POIS and review of excitotoxicity
« Reply #24 on: April 23, 2017, 07:49:40 PM »
Maybe we have candida.

Check this out...

https://www.ncbi.nlm.nih.gov/pubmed/20624941
My POIS Symptoms:  Brain Fog, frustration, stuffed nose, anger, anxiety, intense hunger, low self esteem, swollen face, and feel zoned out.

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #25 on: April 24, 2017, 01:19:59 AM »
Maybe we have candida.

Check this out...

https://www.ncbi.nlm.nih.gov/pubmed/20624941

Interesting.  I think a weakened immune system is a necessary requirement for POIS, and Candida is not only caused by a weak immune system but it can also worsen the immune system by causing leaky gut syndrome, imbalanced gut flora, and adrenal fatigue/HPA dysfunction.  I always knew Candida affected many POIS sufferers, caused by lowered immunity, but I've looked into it more and I learned it can be caused by taking antibiotics or eating a high sugar diet as well.  I believe this article does support us having Candida, so I've read through that article and a few others about Candida.  I found a Candida quiz that seemed reliable (http://bodyecology.com/quiz.php), and it said I almost certainly have Candida.  After a lot of reading up on Candida I think it might be behind gut problems, along with many other symptoms of POIS, for the following reasons.

Research from Rice university shows that 70% of all people have Candida infections, and this is rising due to factors like lowered gut diversity, poor food quality, poor diets, widespread use of antibiotics, and other drugs that create an acidic environment which weakens our immunity.  Candida can cause dozens of symptoms, because it produces toxins and causes inflammatory and autoimmune reactions (which can lead to autoimmune disease).  Candida also lowers nutrient absorption, and can produce a neurotoxin named acetaldehyde (the same chemical that causes hangovers).  High levels of acetaldehyde taxes the liver, which reduces its ability to store and use the essential vitamin B12, this along with other factors puts excess stress on others organs like the brain (which uses lots of energy to pump calcium out of neurons, preventing excitotoxicity).  Acetaldehyde also can cause a deficiency in B1 (crucial for good brain health), binds with dopamine (why alcoholics are usually depressed), can damage nerve cells in a similar way to chronic alcoholism or Alzheimer's, and makes red blood cells less effective at carrying oxygen to the brain.  All this damage from one toxin, and Candida produces around a hundred toxins, including other serious ones like ammonia and uric acid. 

While the body is processing Candida toxins it also must fight Candida and maintain energy levels so neuronal death doesn't occur.  This can deplete hormones like pregnenolone, cortisol, and DHEA, which are also being used by the body to counter inflammation.  Candida can also suppress the production of serotonin, crucial in depression.  Candida also down regulates IL-17, perhaps as a defense mechanism, as IL-17 is very important in removing Candida.  Recent research suggests that it might directly bind to Candida and induce nutrient starvation conditions in the organism.  Candida down regulates IL-17 by shifting the Kynurenine pathway the opposite direction that POIS does, which may support its proliferation in our bodies as a way to counter this effect.  Coincidentally, Staph. A infections counter the inflammatory effects of Candida, and a few years ago I had a antibiotic resistant Staph A. infection (MRSA).

Throughout my life I've also had chronic bronchitis, colds, enteroviruses, and as a kid I had asthma, Tourette's syndrome, and Sydenham's chorea.  This makes me think that I either have a bacterial infection or are very vulnerable to them.  Candida causes physical damage to endothelial cell walls, making them vulnerable to bacteria.  As a result, 1 in 4 patients with Candida also have a bacterial infection. (https://www.ncbi.nlm.nih.gov/pubmed/17888612)

Now how could we treat Candida and possible polymicrobrial infections?  I need to look more into this but it seems like I've already figured most of it out by cutting sugar, milk, and recently gluten from my diet, taking antimicrobial supplements like Resveratrol, Olive Leaf Extract, and Andrographis, and IL-1 antagonists like Luteolin for the following reason:  "'Interleukin 1b is now turning out to be a decisive molecular switch, which the microbes use to dictate between healthy or sick,' says Dr. Christina Zielinski. She sees great potential in the therapy of inflammatory diseases by blocking this messenger substance. In contrast to other immune therapies this does not lead to a weakening of the immune system, but rather enables the cells instead to be anti-inflammatory if needed, without losing the ability to fight dangerous pathogens."
(https://www.candidaplan.com/620/candida-linked-to-arthritis-multiple-sclerosis-psoriasis-and-other-autoimmune-conditions/)

notmythirdaccount

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Re: New ideas about POIS and review of excitotoxicity
« Reply #26 on: April 24, 2017, 11:36:51 AM »
Hey guys,

I wanted to throw my experience into the mix.

TLDR: I think POIS has an immune, microbial, viral infection link, and Olive Leaf Extract seems to have helped. I have been taking most of the other vitamins for months without much change, however OLA seems to have improved my overall symptoms.

I have begun taking multivitamins and supplements diligently over the past three weeks. I can safely say that my symptoms have improved. My symptoms basically last only 1 day, following ejaculation. Day 2 and onwards is solid.

I've noticed no negative change by doing this (although you should take my and anyone else's information with a grain of salt and caution.) My libido is the same if not higher, my mood is more stabilized (day 1 is still rough, albeit better.)

The best part is not having muscular contractions or aches following an O. They're virtually non-existent. I can work-out like normal. On day 1 of POIS, I managed to run a total of 2 miles at a pace I've never ran before. I'd say that's an improvement.

So, on to the good stuff. Going off the first post in this thread, I do feel that POIS has an immune link, and also a bacterial, infectious or viral sickness link. I've had a couple of bouts of Staph infection in the past, one of which caused me to miss 3 weeks of work a few years back. I was on anti-biotics, but to be perfectly honest I may not have used all of the pills.

Additionally, as a child I was constantly sick with diarrhea or rashes. Growing up, I had a feeling that my immune system was crappy. But it's taken me a while to connect the dots.

I feel like I'm rambling, but will get to the point. Out of all the supplements that I have been using, like others in this thread, I feel that Olive Leaf Extract has been the most potent.

Unfortunately, I don't have a way of narrowing it down to OLA, but I feel that it plays an important role in my recovery and well-being.

My total regimen includes:
B-Complex (100mg?)
Quercetin Complex (with Vitamin C.) (500mg)
Vitamin D (5,000 IU)
Basic multivitamin (with Vitamin E, and other needed traces.)
Niacin (500mg)
Iron (60mg)
Ashwagandha
Olive Leaf Extract

I take all of these once a day, in the morning. I don't like using percentages because it's subjective, but I feel...at least at 70% on day 1, and 90%+ on day 2 and onwards. Before, my symptoms would last 2-3 days, and they were more severe.

I'd also like anyone else's bowel experience following an O, and the day after. When I release, it's as if my bowel movements entirely shut down. I can eat tons of food that day, and it seems like nothing is processed. I've also experienced this while taking Niacin, for example. Sometimes the Niacin will not work. I take 500mg and can feel the flush every time, so it baffles me why I can't feel it some days after an O. It's like my system goes on pause-mode on day 1. Once day 2 starts, I can use the restroom normally.

The gut has got to be important in this as well. I will try to get my hands on a high-quality probiotic to add to my stack.

Hope this helps.

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #27 on: April 24, 2017, 10:45:51 PM »
Hey notmythirdaccount,

Thanks for sharing your experience, I agree with your views on POIS and I'm going to start taking Olive Leaf Extract and other antimicrobrials on a daily basis. 

I originally thought just taking them before O would be enough, but my last two tests with these supplements have convinced me otherwise.  Both times I was missing a few supplements (neuroprotek, h2 blocker, b complex), and although they still gave me like 70% POIS relief, I was disappointed because I was still tired, unmotivated, out of it, and a little depressed.  Because I've done just about everything else I can try, I'm seeing my endocrinologist Wednesday and telling him I think I have candida, and that is has either made my immune system very vulnerable or it has allowed bacteria to colonize somewhere in my body.

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #28 on: April 26, 2017, 04:17:03 AM »
Maybe we have candida.

Check this out...

https://www.ncbi.nlm.nih.gov/pubmed/20624941

The more I read about Candida, the more convinced I am that it is causing POIS.

VagSmasher, I'm really glad you started a discussion about Candida in this thread, because it fits like a puzzle piece with everything I've described in the first page.  I thought the fact that I tended towards certain bacterial illnesses meant I had a bacterial infection, but that doesn't really make sense because I've had a wide range of both viruses and bacterial infections at a rate that just about everyone in my life has noticed and commented on how often I get sick.

Candida could not only make the body vulnerable to these illnesses, but it could do this consistently because it can evade detection.  How does it do this?  In the same way that I proposed the bacterial infection could, through molecular mimicry.  This leads to systemic auto immunity, as candida has been proven to cause fibromyalgia, something that runs in my family along with many other Candida/POIS related issues.  The genetic components that allow this are described in the first page of this thread, and has evolved because once we treat the Candida infection, these genes should give us an above average resistance to cancer.
(Read this article, much more info about this: http://nutritioninstitute.com/fibromyalgia/)

Now I know what your thinking, POIS isn't like fibromyalgia, but that's because there is a rather rare occurrence in POIS sufferers, which is the breakdown of the Blood Brain Barrier (BBB) during sex.  Rather than Candida's toxins just attacking nerves, it attacks the central nervous system.  Many factors can lead to the breakdown of the BBB, but during sex there is only one, the natural release of histamine which reliably opens the BBB.  This exposes the brain to around 100 extremely poisonous toxins like Acetaldehyde and Ammonia, which not only taxes your liver and kidneys, but triggers IDO activation and Kynurenine production to protect the brain at the cost of significant excitotocitiy.  This requires every ounce of energy in your body to protect you from stroke or seizure, which puts significant strain on the HPA (Hypothalamus-Pituitary-Adrenal) axis and depletes your body of hormones.  Dietary factors, particularly alcohol, sugar, and antibiotic consumption will feed the Candida and result in worse symptoms.  Even a comprehensive strategies to eliminate POIS will never completely work until Candida is removed from our bodies, so I'm going to ask my doctor to prescribe me a special antibiotic for fungal infections called nystatin later on today and see what he says.

VSmasher

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Re: New ideas about POIS and review of excitotoxicity
« Reply #29 on: April 27, 2017, 07:08:26 PM »
Yes. I think candida affects alot of people without them knowing it. There's even an Italian MD that says candida is the cause of cancer. Now, I just saw on the news that there's a new form of candida from China called Candida Auris that can KILL you! Shits crazy. I ate a ton of sugar all my life. My intestines are probably loaded with fungus. Also, I get POIS symptoms when I take herbs and supplements that kill candida. Maybe POIS is actually candida die off.

Things I take to kill candida...

raw garlic
Niacinamide
Raw coconut oil
Olive leaf xtrct
Grapefruit seed xtrct
Eat no sugar diet.

« Last Edit: April 30, 2017, 10:46:47 PM by VagSmasher »
My POIS Symptoms:  Brain Fog, frustration, stuffed nose, anger, anxiety, intense hunger, low self esteem, swollen face, and feel zoned out.

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #30 on: April 28, 2017, 10:44:17 PM »
Yes. I think candida affects alot of people without them knowing it. There's even an Italian MD that says candida is the cause of cancer. Now, I just saw on the news that there's a new form of candida from China called Candida Auris that can KILL you! Shits crazy. I ate a ton of sugar all my life. My intestines are probably loaded with fungus. Also, I get POIS symptoms when I take herbs and supplements that kill candida. Maybe POIS is actually candida die off.

Things I take to kill candida...

raw garlic
Niacinamide
Raw coconut oil
Olive leaf xtrct
Grapefruit seed xtrct
Eat no sugar diet.

Everyone on here should try it and see if it affects POIS in any way and report back here.
Thanks!!!!

Yeah I agree with that you it's crazy, that most doctors around the world ignore a fungus that can cause autoimmune disease, cancer, and even kill you is absolutely insane.

When I was at my endocrinologist on Wednesday, I brought that candida quiz that I linked to (in this thread), which said I almost certainly had it.  I told him that, and said the quiz had just about every single serious health symptom I was experiencing, and tried to hand the list to him.  As I held the papers out, he said he didn't want to look at them because as far as he was concerned, it was "bogus".

Then he went on and tried convince me I wasn't there for the symptoms I had repeatedly told him about, but had actually come to him for frequent urination, something which I never even wanted him to treat.  He just forced that upon me because he thought that was the most serious symptom, even though I listed at least five other more serious symptoms.

Needless to say, I was out of that office in five minutes and will never be going back to that guy.  This was my first time trying to seek professional help for POIS, and 6 months, 2 appointments, and a few hundred dollars thrown out the window later, I probably will never be trying that again.  Glad I listened to everyone's advice on this forum and tried to figure out POIS myself, trying to get help for POIS from that guy probably would've required dozens of tests and thousands of dollars.

I'd much rather try to treat Candida naturally anyway, so I just ordered three new supplements, and plan on trying these.  I have no clue what effects these will have, and ever since I started taking OLE andrographis and resveratrol my symptoms have gotten worse, not sure if I'm just stressed out about finals or if they're giving me side effects, so don't take any of these but I'll let you guys know how much they help.

http://www.iherb.com/Wakunaga-Kyolic-Kyolic-Formula-102-Candida-Cleanse-Digestion-100-Veggie-Tablets/56189
(Kyolic Formula 102 herb & enzyme blend, contains a unique, natural and synergistic combination of Aged Garlic Extract, Ginger, Glucanase, Lipase and Protease)

http://www.iherb.com/Now-Foods-Candida-Support-90-Veggie-Caps/462
(Candida Support is a combination of traditional herbal ingredients (Pau D'Arco, Black Walnut and Oregano Oil), Biotin (a B-complex vitamin) and Caprylic Acid (a naturally occurring fatty acid derived from plant oils)

http://www.iherb.com/Nature-s-Sources-Kolorex-Advanced-Candida-Care-60-Softgels/6634
(Kolorex Advanced Candida Care helps maintain balanced intestinal micro-flora, using a patented extract of New Zealand RedLeaf Horopito.)

Along with VagSmashers suggestions
Raw Coconut oil
Olive Leaf Extract
No sugar diet

And a few of mine
Andrographis
Resveratrol
Probiotics
« Last Edit: April 29, 2017, 03:20:04 AM by trusttheprocess »

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #31 on: May 04, 2017, 01:32:04 AM »
Found a better quiz for diagnosing Candida:  http://www.wholeapproach.com/candida/questionnaire.php

This link was in an article about histamine intolerance, the author of the article said they "scored a whopping 200 points!"

I scored 395.

This is very troubling as the author was a woman, and I should be less susceptible to Candidiasis for the following reasons:
(from http://thehistamineintolerantchick.blogspot.com/2013/08/coulld-candida-albicans-be-causing-your.html)
  • "C. albicans growth is stimulated by the female hormone progesterone. Its levels are elevated during pregnancy and in the second half of each menstrual cycle. Synthetic progestins are found in oral contraceptives and also contribute to candida overgrowth."
  • "Female hormonal levels are constantly fluctuating and sustained high levels of estrogen can occur. This condition tends to impair immune system function."
  • "The female anatomy lends itself to the ready migration of C. albicans...yeast infections are a common result."
Why did I score so highly on the quiz then?  Without getting into the genetic factors behind this, I can think of two reasons.
  • Candida triples histamine levels in people with asthma (asthma runs in my family, from study "Concentration of LTC4 and Histamine in Serum and IgG Against Candida albicans")
  • Some people are allergic to Candida, results in a 20% higher histamine level on average when it's put on the skin (allergies run in my family, from study "HRA: Production by Mitogen or Antigen-Stimulated Human Mononuclear Cells")
Below is a good explanation of the link between histamine and candida, and some effective ways to treat Candida.
Quote
"Research shows that Candida triggers histamine release, but did you know you can be allergic to candida, causing repeated, longer lasting or more intense infections? Or that those with chronic candida are 70% more likely to have a history of family allergies and allergic rhinitis? There?s really exciting news though ? Tufts researchers have made a discovery that will rock our world!

Will treating Candida help resolve histamine intolerance/excess histamine/mast cell activation?

Possibly.

Are there natural treatments available?

Yes! A recent study by researchers at Tufts has found that a coconut oil rich diet reduces the amount of Candida albicans in the gut by more than 90% in mice [1].

More on that below.

Before proceeding, I?m just adding a quick update on a new review published in the European Journal of Pharmacology which discusses the findings that curcumin, extracted from turmeric, may be an appropriate treatment for invasive fungal infections like candida in cancer patients [1a].

We?ll have to wait for convulsive results but I thought it worthy of a mention given the study I read in Critical Reviews in Microbiology which shared something new to me: not only does candida take advantage of the immunocompromised by increasing the risk of carcinogenesis and metastasis in those undergoing chemotherapy, but that new research indicates candida may cause cancer progression by triggering inflammation [1b].

Back to the histamine connection.

Most, if not all, bacterial, viral and fungal infections cause an immune system response which comprises the release of histamine and many other inflammatory molecules [2].

A number of studies, including one published this year (2015) in the Nature Journal show that candida infection triggers mast cells to release inflammatory mediators to try and kill off the fungus [3].

As you?ll remember, histamine is found outside of the body in foods but it?s also present in our body, where it lives in mast cells, which are a key component of our immune system. When mast cells freak out for no reason (like in mast cell activation disorder/syndrome) or need to get in there and fight a pathogen, they do their degranulation boogaloo, shaking loose a ton of inflammatory cytokines to get the healing process going.

In 2012 authors of a study published in Frontiers in Immunology concluded that mast cells could be involved in the defence against Candida albicans by releasing histamine [4]."  (https://healinghistamine.com/are-you-allergic-to-candida/)

Candida, Histamine, and Leaky gut all seemed to be linked, probably because Candida can put holes in cell walls, damaging and destroying them.  This will lead to an immune response, allergies, and mast cell activation.

"Studies show that if your gut is colonised with the fungus Candida you are likely to become sensitive against food antigens (food allergy), because of the increased number of mast cells, and the hyper permeability of the gastrointestinal mucosa (which is caused by histamine release).  If you have histamine intolerances and food allergies it is very important to test for pathogens. As a minimum they can be contributing to the histamine load if you have a histamine related disease. They could also just be the cause." (http://alisonvickery.com.au/fungal-infections-histamine-intolerance-and-mast-cells/)

These gut issues can also lead to low levels of DAO, the main factor in histamine intolerance.  A list of conditions that cause DAO deficiency is listed below:
  • Gluten intolerance
  • Leaky gut
  • SIBO
  • DAO-blocking foods: alcohol, energy drinks, and tea
  • Genetic mutations (common in people of Asian-descent)
  • Inflammation from Crohn?s, ulcerative colitis, and inflammatory bowel disease.
Or taking any of the following medications: (from (http://www.amymyersmd.com/2016/02/everything-you-need-to-know-about-histamine-intolerance/)
  • Non-steroidal anti-inflammatory drugs (ibuprofen, aspirin)
  • Antidepressants (Cymbalta, Effexor, Prozac, Zoloft)
  • Immune modulators (Humira, Enbrel, Plaquenil)
  • Antiarrhythmics (propanolol, metaprolol, Cardizem, Norvasc)
  • Antihistamines (Allegra, Zyrtec, Benadryl)
  • Histamine (H2) blockers (Tagamet, Pepcid, Zantac)
Note: Don't know if this entire list is accurate.  Tagamet did inhibit DAO by 25%, but Benedryl increased DAO by 20%, and Zyrtec and Zantac had no effect (from (http://www.ncbi.nlm.nih.gov/pubmed/9831324?dopt=Abstract).

Other factors can raise histamine levels even more such as allergies, histamine-rich foods, and HNMT, MAO, NAT2, or MTHFR deficiency.  This explains why B vitamins help POIS, as they are required for these histamine clearing enzymes. (http://mthfr.net/histamine-intolerance-mthfr-and-methylation/2015/06/11/)
  • HNMT ? which requires SAMe as a cofactor (and this requires an effective MTHFR enzyme to help produce SAMe)
  • DAO ? which requires vitamin B6 and copper
  • MAO ? which requires vitamin B2 and iron
  • NAT2 ? which requires CoA which stems from vitamin B5
I want to talk about why Candida/Histamine are so imporant now, so if you want to know more about treating histamine intolerance, read this website (https://selfhacked.com/2014/08/01/deal-histamine/).

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #32 on: May 04, 2017, 05:49:54 AM »
Importance of Candida related Histamine release

High levels of histamine are not healthy, one reason for this is because it opens the blood brain barrier.  This can allow Candida, or at least the toxins it produces, into the brain.  Although the causes behind it aren't clear, Candida can cause meningitis, something that is recognized by the Meningitis Research Foundation (http://www.meningitis.org/disease-info/types-causes/fungal).  Due to the link between Candida overgrowth and Histamine intolerance, and the interaction between them just worsens symptoms until a diet that doesn't feed Candida is adopted.

Overview of Fungal Meningitis (Gottfredsson, Magn?s, and John Perfect. "Fungal Meningitis.")

"Fungal infections have increased in incidence. This increase is attributed to an enlarging population of high-risk immunosuppressed patients, which is due in part to more successful pharmacological immunosuppression and chemotherapies and the frequent use of antibacterial and antiviral therapies. In addition, large numbers of patients living with human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS) develop life-threatening fungal infections during the course of their illness. As a result of these trends, central nervous system (CNS) infections caused by opportunistic fungal pathogens are becoming increasingly relevant. In addition, seemingly immunocompetent individuals can acquire these CNS infections with fungi.

In the majority of cases the fungus appears to seed the CNS hematogeneously, usually from a pulmonary focus of infection but occasionally from extracranial sites such as infective endocarditis. Direct extension of fungal infections involving the cranial bones or sinuses into the subarachnoid space has also been described, usually causing basal meningitis or mass lesions. For clinicians, the varied clinical presentations of fungal meningitis and its possible concomitant brain parenchymal involvement constitute a major diagnostic challenge, because the yield of traditional diagnostic methods, such as culture, may not routinely be positive. Moreover, as more potential treatment options for these CNS infections become available, a timely and accurate diagnosis is crucial to improve prognosis for these seriously ill patients. In this review, we examine the topic of fungal infections of the meninges in both a general and a fungus-specific format...

The brain and the subarachnoid space are considered immunologically sequestered sites. The subarachnoid space has anatomic and functional barriers that exclude or modify immune responses. Except for the apparent neurotropism of C. neoformans, it remains unclear why this fungus uniquely invades this privileged sanctuary and what factors possessed by the fungus allow it to do so. On the other hand, although some patients with fungal meningitis have no overt immune defect or underlying disease, most patients with this infection have some predisposing factors or immune abnormalities that allow invasion by these low-virulent pathogens.

Certain clinical conditions have been identified that lead to failure of these host defenses. For example, direct inoculation of fungi into the brain following head injuries or neurosurgical procedures is an easily defined pathological mechanism. However, there can be subtle local immune cell dysregulation that allows establishment of meningitis; for instance, development of suppressor T cells in cerebrospinal fluid (CSF) has been observed in a case of Histoplasma meningitis.   Even potent antibacterial regimens may be a contributing factor to Candida meningitis. Corticosteroid treatment is a risk factor for fungal meningitis, and C. neoformans is the most prominent fungus complicating corticosteroid use.  The host immune responses and underlying disease are not only the major factors in the pathogenesis of these infections but also the most significant determinants of outcome in the patients.

All types of invasive infections with C. albicans and other Candida species are increasing in prevalence. The clinical symptoms of Candida meningitis are highly variable and can range from acute to chronic in nature, with headache and fever the most common clinical manifestations. In patients with Candida meningitis without concomitant HIV infection, [neck] rigidity is also commonly detected.  Almost all of these patients have also received broad-spectrum antibacterial agents and in some reports have had an antecedent bacterial meningitis.  In rare circumstances, Candida species can invade the subarachnoid spaces from the sinuses and the adjacent bone.  This is generally associated with an anatomic defect. Intracranial extension of the Candida infection can lead to arteritis within the CNS and subarachnoidal hemorrhage.

All Candida meningitis cases should be aggressively treated. The mortality for Candida meningitis with treatment has been reduced to 10 to 20%. The combination of amphotericin B and flucytosine is attractive as the regimen of choice because this combination has synergistic activity against Candida in vitro and flucytosine immediately reaches high concentrations in the CSF. Clinical experience suggests that this combination provides an excellent cure rate."

Pathology of fungal meningitis (S?nchez?Portocarrero, Jorge, et al. "The Central Nervous System and Infection by Candida Species.")

"When the CNS is involved in patients with systemic candidiasis, several clinical manifestations can be overlooked due to the severity of the patient?s situation. The decrease in the level of consciousness is the most frequent manifestation of CNS candidiasis. Often, not much attention is given to this manifestation when we come across septic patients suffering from severe illnesses in intensive care units, patients undergoing invasive procedures or sedated on drugs. Studies of the brain of patients who died from systemic candidiasis have concluded that up to 50% had CNS invasion by Candida species.  However, these patients were rarely diagnosed when alive because of the lack of clinical manifestations.

Recently, Candida species have been considered to be responsible for other neurologic clinical manifestations besides decreasing the level of consciousness. We therefore think that it is necessary to review the full and constantly changing spectrum of neurologic pathology caused by this microorganism.  The physiopathology of Candida CNS involvement varies according to the clinical setting. When systemic candidiasis is prolonged, it can affect the CNS and induce diffuse encephalopathy with diminished consciousness in which the predominant lesions are microabscesses. These have been reproduced experimentally by introducing C. albicans into the internal carotid of rats, thus simulating candidemia.

Pathologic findings are many. Microabscesses are usually found in the joint between the gray and white matters and they are widely spread in the CNS, being the basal ganglia and the cerebellum the sites more frequently involved.  Other findings are macroabscesses and lesions of vascular origin such as cerebral infarcts by vasculitis or mycotic aneurysms.  Up to 23% of patients with CNS candidiasis in necropsy studies may have evidence of vascular invasion, either in the vascular wall itself or with invasion of the arterial lumen. When cerebral ischemic damage exists, the infarcts are usually found in the basal ganglia. Old vascular lesions such as operated subdural hematoma can be infected by Candida species (Lipton et al., 1984). In general, these vascular complications seem to have a less important clinical role, although invasion of the arteries at the base of the brain by the fungus can produce transitory or permanent neurologic deficits.  Microabscesses cannot generally be seen on the cranial CT scan. They can be observed using magnetic resonance (MR) imaging, where they are seen as small enhanced ring lesions with a hemorrhagic component and widely spread in the brain."



Quantum

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Re: New ideas about POIS and review of excitotoxicity
« Reply #33 on: May 04, 2017, 06:53:23 AM »
Hi TTP,

Have added yet coconut oil and curcumin to your diet, the proposed natural cure for candida proposed in one of your references ?

I note that having a healthy diet and incorporating healthy food has many advantages, beyond what we may be aware of.   I say that because I already have turmeric/curcumin incorporated in my daily diet for at least 2 years, and in January, I have started to add organic coconut oil to my green smoothies ( I like its smell and its taste !   Be aware that if the coconut oil you use do not have a coconut smell, it has been tempered with and is not as healthy).

DAO has been discussed as a solution.  A member seemed to have some good initial results, but we did not have any news after.  One other member reported no effect with DAO.  But we already no that no one product works for every POIS sufferer.
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

trusttheprocess

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Re: New ideas about POIS and review of excitotoxicity
« Reply #34 on: May 04, 2017, 12:13:20 PM »
Quantum,

I haven't added coconut oil to my diet yet, although I plan on doing that sometime this weekend. 

Curcumin I have been using for a long time as the main anti-inflammatory for me during POIS.  I used to use Aspirin, but I have always mixed many different supplements and I didn't want to risk stomach or liver damage.  The health benefits of curcumin are staggering, I think it belongs in the "elite" tier of supplements with the most benefits, along with green tea and fish oil.  Check out these 37 proven health benefits if you don't believe me: https://selfhacked.com/2016/03/14/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/

I agree with you that healthy diets are very important, cutting out dairy, MSG, aspartame and most gluten and sugar has helped me tremendously.  I'm not an expert on healthy foods so I've mainly just tried to start eating organic salads with vegetables mixed in.  Also was eating blueberries for a while, they are excellent at reducing neuro-inflammation. 

I've never tried DAO but have always wanted to.  As I mentioned in my post, low DAO it is the main risk factor in elevated histamine but many other things can cause it including candida.  I would think a healthy diet would work better than DAO because it treats the cause of the elevated histamine, the candida, and not just the body's response to it.

Mr Raba

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Re: New ideas about POIS and review of excitotoxicity
« Reply #35 on: May 04, 2017, 02:24:36 PM »
TTP,

I have both CFS and POIS.  Latest studies have found a state of induced hypometabolic state such as in sepsis with CFS. Also remarkable findings in the pathways you describe.

I do not know if you are aware of the latest CFS research which is now a breakthrough after a breakthrough.

I strongly encourage you to look at several excellent articles regarding energy impairment and compensations ocurring to bring homeostasis in this excellent blog site:  Health Rising.  Here is one such article that discusses calcium channels involvement. Look at older posts in same blog  for a literal gold mine of info on inflammation and energy pathways.

https://www.healthrising.org/blog/2017/02/28/biomarker-aussies-chronic-fatigue-syndrome/

Simultaneous onset of CFS and POIS since Feb 1993. Married since 1989.

Helped by Immunocal (I explained how to take in previous posts).  Some relief on day one and day two.  It affects neurotransmitters.

VSmasher

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Re: New ideas about POIS and review of excitotoxicity
« Reply #36 on: May 06, 2017, 11:43:12 AM »
Yes. I've long believed that POIS is caused by High brain histamine. Histamine is the neurotransmitter that makes you orgasm. The higher your brain histamine, the quicker you orgasm. That's why so many of us have Nocturnal emissions and Premature ejaculations.

Candida increases histamine which can increase POIS. Intense exercise also increases histamine. So does STRESS and ANXIETY. (Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress causing even more histamine to get into the brain!!!)

Not only does high histamine increase orgasm, but orgasm increases histamine. It's a never ending cycle. Maybe our H3 receptors aren't working? ( they work to control histamine like an automatic feedback loop)

The Diencephalon part of the brain is our emotional center. It is surrounded by mast cell. The mast cell release histamine into Diencephalon causing emotional sensitivity, anxiety, autism, brain fog, and Pois??...
« Last Edit: May 06, 2017, 12:18:08 PM by VagSmasher »
My POIS Symptoms:  Brain Fog, frustration, stuffed nose, anger, anxiety, intense hunger, low self esteem, swollen face, and feel zoned out.

ThisType

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Re: New ideas about POIS and review of excitotoxicity
« Reply #37 on: May 07, 2017, 07:56:02 AM »
VagSmasher, that's an interesting theory.  I have a benign pineal cyst seen via MRI.  The Diencephalon (https://en.wikipedia.org/wiki/Diencephalon) includes the pineal gland (https://en.wikipedia.org/wiki/Pineal_gland).  I see the cluster 1 symptoms of POIS (speech, brain fog, etc) per (http://tau.amegroups.com/article/view/11107/11778).

demografx

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Re: New ideas about POIS and review of excitotoxicity
« Reply #38 on: May 07, 2017, 02:36:13 PM »
Interesting, TT.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Going less Crazy

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Re: New ideas about POIS and review of excitotoxicity
« Reply #39 on: May 08, 2017, 05:05:03 AM »
Hmm maybe that's why vitamin c has helped me, antihistamine?

I didn't read too much but candida could be a possibility by paving the way for food sensitivities, Intolerance/auto immune issues causing high histamine and other inflammatory issues.  Im not sure if "curing candida" would resolve this issue once your immune system has tagged food a foreign invader.
« Last Edit: May 08, 2017, 05:09:03 AM by Going less Crazy »
My POIS managed with Diet (@ diet that 100% manages my pois)Believe my POIS stems from inflammation in the gut. O = neuro POIS from inflammation from the gut

Current supps: thyme and melatonin for sleep, zyrtec anti-pois.