Author Topic: Phenoxybenzamine (Dibenzyline)  (Read 2071 times)

biocentric

  • Lab1
  • Jr. Member
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Phenoxybenzamine (Dibenzyline)
« on: May 22, 2011, 06:17:16 AM »
Has anyone tried Dibenzyline???
thanks!

http://en.wikipedia.org/wiki/Phenoxybenzamine
Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-specific, irreversible alpha antagonist.

Uses
It is used in the treatment of hypertension, and specifically that caused by pheochromocytoma. It has a slower onset and a longer lasting effect compared with other alpha blockers.

It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia, although it is currently seldom used for that indication due to unfavourable side effects.
It has been used in the treatment of hypoplastic left heart syndrome.
It is also used in Complex Regional Pain Syndrome Type 1 due to its anti-adrenergic affects. It has shown to be beneficial if used in the first 3 months of CRPS diagnosis.

Phenoxybenzamine has long been known to block ejaculation without affecting semen quality or ability to achieve orgasm, which could make it an effective male contraceptive. This effect is completely reversible, and is believed to be the result of alpha-1 adrenoceptor blockade in the longitudinal muscles of the vas deferens. As of 2008, research was underway to identify possible drug candidates that share this effect but act specifically on the reproductive tract, unlike phenoxybenzamine.

Not sure if this is a good thing or bad thing but "blockade in the longitudinal muscles of the vas deferens" sounds interesting to me as I have a pet theory those Vas Deferen muscles are the key to my POIS problem.

rocketman

  • Guest
Re: Phenoxybenzamine (Dibenzyline)
« Reply #1 on: August 27, 2011, 12:28:34 PM »
Hi,

I was doing some research and came across this article on phenoxybenzamine http://malecontraceptives.org/methods/contraction_inhibitor.php. Have you tried Dibenzyline and what were your results?

Fact that it is also used as a high blood medication may help the migraines. Also, the prevention of sperm mixing with semen may help the autoimmune response, although I am just speculating here.

Thanks,