Author Topic: Experience with Galantamine,  (Read 3173 times)

romies

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Experience with Galantamine,
« on: December 16, 2016, 12:49:43 PM »
At the suggestion of nightingale, I recently tried Galantamine and received pretty good results in maintaining cognitive function in POIS period (T+24hrs)

Why Galantamine?
It increase choline (Ach) in the brain by inhibiting the enzyme that breaks it down
It activate ?cholinergic anti-inflammatory pathway?
It reduces mast cell and microglial activation in the brain
some details with references: http://www.lostfalco.com/the-brain-fog-two-step/

Who benefits from Galantamine?
    people who respond to Huperzine A
    people who benefit a lot from egg consumption (egg yolk is a good choline source)

Galantamine vs Huperzine A
    Galantamine is similar to Huperzine A, but has a much longer half life. I personally respond a bit better to Galantamine

When to take Galantamine
    Morning or noon time. Ideally not before sleep, since it tends to generate lucid dreams/nightmares in some people
    It is not in my pre-pack and I have not tested whether it is important.

I take Galantamine 4mg in the morning occasionally (every other day) and it seems to be sufficient.

Credit: I really should acknowledge nightingale for the lead to all these intriguing reading.
« Last Edit: December 16, 2016, 12:56:56 PM by romies »

Quantum

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Re: Experience with Galantamine,
« Reply #1 on: December 17, 2016, 10:11:02 AM »
Hi romies,

Interesting post.

the use of cholinesterase inhibitors in order to boost acetylcholine activity is totally in line with the current Rutgers study n POIS involving vagus nerve stimulation  ( for those wondering,, the vagus nerve is one of the most important cholinergic nerve in the whole body).  The use of cholinesterase inhibitors like galantamine is just another way to achieve this, and to stimulate the Cholinergic Anti-inflammatory Pathway  ( CAP) .   For more information about all this, those interested can see this post I have written about CAP and the ways to stimulate it : http://poiscenter.com/forums/index.php?topic=2200.msg17995#msg17995 .

Eating eggs, yes, may be linked too, because egg yolks are an excellent source of choline.


The CAP can also be simulated via non-invasive techniques, like meditation, and yoga.


I have huperzine A at hand, but having no cognitive issues in POIS, I didn't use it very often.

Galantamine is more potent, but then, you have to be careful, because stronger main effect also means stronger side effects.  That is why I stay away as much as possible form prescription drugs.  But if anyone choose to go this way, in agreement with his helath professional,  than the way to go is to carefully control for the optimal dosage, which is always the lowest effective dose, than you lower the risks.  Another way to stay safe is to be aware for what side effects might occur.  With galantamine, keep an eye on gastro-intestinal disturbance, and on slow heart rhythm  ( https://en.wikipedia.org/wiki/Galantamine#Side_effects ).


Ibudilast, talked in the reference you gave about brain fog, is available mainly in Japan.  But other PDE4 inhibitors are of interest ( https://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor),  in particular luteolin, that I have already talked about on the forum because of its mast cells stabilizing properties.  Luteolin can be found in artichoke and chamomile flowering tops and some other sources, and in some supplements as well ( https://en.wikipedia.org/wiki/Luteolin ).


Let us know about your long term results with galantamine.

You say you take 4mg every other day.  Does that mean that, even out of POIS, you have have been suffering from a certain level of brain fog that is always present ?
« Last Edit: December 17, 2016, 10:13:29 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

romies

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Re: Experience with Galantamine,
« Reply #2 on: January 08, 2017, 02:25:05 PM »
A quick update here. I am reducing my Galantamine intake to around once a week (on the average), when I realize my working memory is deteriorating. I found only 50% of the time I need to take galantamine after an O, usually around T+24 hrs.

I don't need galantamine to be included in my pre-O pack.