Interesting new theory, Mrraba, but it will take some time to really grasp all it implies. I will look more into it. It will take some time for me to study it, since it covers a large array of metabolical events. But, just looking at the B section of figure 2, showing 9 metabolic processes with their ill or healthy state, is very striking - many, if not all, of those nine process have been discussed on the forum ( gut microbia, mehtylation, kynurenine production via tryptophan pathways hacking, etc...). Needless to say that it is an ambitious synthesis of what is causing "chronic metabolical illnesses", or the like those resisting modern medecine so far ( including CFS/ME, and POIS !)
The old pathways mentioned, those controlling the so-called CDR, are not without reminding me of the "old vagus" response mentioned in the polyvagal theory, and could be one and the same, viewed from different angles.
Interesting enough, the article states that lysine supplements opposes CDR, and I have some lysine coming in my current supplements order ( i wanted to test its anxiolytic properties). However, I would never, never take Suramin, the drug used by Dr Naviaux ( mainly on rats, I think, hopefully), it is a very dangerous drug, with very severe side effects ( including sudden deaths, leading to stop using it in HIV patients ). I prefer, to say the least, Lysine, a naturally occurring amino acid, or safe, low doses of P5P ( vitamin B6)
