I saw the same article earlier, thought it would be interesting to know if we had similar formations in the brain. CFS is an energy problem, and I think that POIS at its core is an energy issue as well. I'm currently waiting to hear from a naturopath who understands methylation, I ran into so many obstacles in trying to supplement for methylation that I needed an expert to help me find the steps I need to take. This ultimately would result in improved mitochondrial function, and that means energy function too.
But brain topography is something that requires another approach to view, diagnose and potentially treat. Am curious about how long term usage of a vagus nerve stimulator would affect these areas discussed in the papers.