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Author Topic: Does POIS result from overstimulation of muscarinic receptors  (Read 18240 times)

Cursed

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Re: Does POIS result from overstimulation of muscarinic receptors
« Reply #20 on: September 09, 2021, 10:09:56 AM »
Quote from: FernandoPOIS on September 09, 2021, 08:50:46 AM
This entire process that we go through is due to excess vasodilation caused by stress that causes low serotonin, sedentary lifestyle that causes low dopamine and endorphins and muscle weakness (genetic) that makes us more susceptible to pain and tension. As long as this cycle is not broken, studying receptors and drugs wont help.

Actually nothing you have said here makes much sense, and it's not relevant to the topic being discussed.
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BuckarooBanzai88

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Re: Does POIS result from overstimulation of muscarinic receptors
« Reply #21 on: September 13, 2021, 05:47:23 PM »
Predisone is one of the few drugs that helps me.  At a high enough dose, I don't have any symptoms.  I was just wondering, is there any explanation of prednisones' efficacy (for my particular biology) that would serve to substantiate this theory?
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demografx

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Re: Does POIS result from overstimulation of muscarinic receptors
« Reply #22 on: September 14, 2021, 05:57:52 AM »
Thanks, BB88, I assume the higher dose anti-POIS efficacy has a significant downside of side effects for you?
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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Progecitor

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Re: Does POIS result from overstimulation of muscarinic receptors
« Reply #23 on: September 14, 2021, 12:34:20 PM »
Quote from: BuckarooBanzai88 on September 13, 2021, 05:47:23 PM
Predisone is one of the few drugs that helps me.  At a high enough dose, I don't have any symptoms.  I was just wondering, is there any explanation of prednisones' efficacy (for my particular biology) that would serve to substantiate this theory?

One possible explanation:
High-dose corticosteroid therapy increases plasma SIRT-1.
https://academic.oup.com/ndt/article/36/Supplement_1/gfab078.0020/6288899?login=true

SIRT-1 is a co-activator of PGC-1a and their interaction positively influences mitochondrial biogenesis.
https://poiscenter.com/forums/index.php?topic=3986.msg42372#msg42372
https://poiscenter.com/forums/index.php?topic=2456.msg20886#msg20886
https://poiscenter.com/forums/index.php?topic=458.msg41345#msg41345
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The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.

BuckarooBanzai88

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Re: Does POIS result from overstimulation of muscarinic receptors
« Reply #24 on: September 21, 2021, 02:10:31 AM »
@demografx - I actually haven't had a problem with side effects from Prednisone thankfully!  I've found that if I maintain my vitamin D levels, I don't experience side effects until I get into really high doses of prednisone.  Lately, I've taken around ~7.5mg with no side effects.


@Progecitor - Thanks for sharing!  The doses discussed in that research are way, way higher than what I take.  I wonder if the SIRT-1 increase with my dose schedule would be enough to account for muscarinic effects.
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