I started masturbating from an early age. I think at age 5 perhaps because I remember it was prior to elementary school. My first ejaculation was perhaps at around age 10 or 11. I saw a few entries trying to link this but I don't remember any cases of poisining before POIS. Perhaps there were. But I remember alcohol consumption in small doses during my teens--my late father forced me to consume a teacup of diluted wine on a daily basis thinking it would help ectomorph me gain weight. I'm not sure how long that 'programme' lasted. Maybe a month. Maybe more. I don't drink or smoke at all, by the way. No illegal drugs either.
Now for the severity of symptoms. I think they were the most severe during my twenties, judging by the mental symptoms that were pretty much life wreckers. I can't forget that. I'm still trying to erase their rippling effects or at least be ready to deal with their haunting ghosts today. I'm 33 now and feeling better about coping with, and recovering from, POIS. I'm not sure what lessened the severity of the symptoms AND sped up recovery times, but here are my guesses:
1) Discovering POIS! Knowing that I have (or may have; always the skeptic) this condition/syndrome helps me manage it more effectively and more directly than before when I had thought my myriad of symptoms were disconnected and unrelated.
2) The gym! I started a strength+stamina training programme in January 2012, and that clearly (to me) sped up my recovery times from 3+ days to 1+ days. And there were days when POIS symptoms were so mild that the next day I was able to have a great day at work and at home. However, I think maybe the training didn't help with the intensity of the symptoms; just the recovery duration.
3) My age? The most related to this thread, could it be that the body starts to cope better with POIS at this stage (when testosterone levels start declining, I presume), provided that POIS had been triggered at an early age? And could it be the opposite for those of us who 'triggered' POIS later in their lives, making it more difficult to manage the symptoms as you age?
One last thing. I'm not sure if it's useful in any way to the topic, but I'm noticeably younger looking physically than what my age lets on. My younger siblings and younger friends have started going bald, many with white hair and smile wrinkles. I sometimes thought that it was perhaps a genetic fluke/mutation rather than directly inherited genes that led to both my appearance and (my readiness for) POIS.