The autoimmune theory is bogus

[kurtosis]

"threat" should have been "treat" and "v vitamins" should have been "b vitamins"
I was typing too fast. Sorry

Although anything that's a threat to POIS is good in my book!

[demografx]

Thanks, kurtosis.

[Nightingale]

From doing some searches, Ciproxifan is no longer in the pipe.  I see there has been some research done since this was apparently decided, but I can't find anything saying it's still in the pipe.  I hope I'm wrong, as it is a really novel drug

[kurtosis]

From doing some searches, Ciproxifan is no longer in the pipe.  I see there has been some research done since this was apparently decided, but I can't find anything saying it's still in the pipe.  I hope I'm wrong, as it is a really novel drug

You're right! Can't find it either. The idea that h3 inverse agonists can be used effectively to treat cognitive impairment conditions is relatively new. Or to be more accurate, it wasn't fashionable until recently.
So if there's a histaminergic element to POIS (I think there is) then it's not a surprise that doctors don't really known how to treat it or even why it might be happening.

Medical science is improving all the time and these drugs are really novel and work in a way that is completely different to amphetamine ADHD medication, as you say. One thing noticed is far less side effects and better patient response over time.  I assume there's still studies being done on Cirproxifan as there are still bulk suppliers making it available to researchers for trial.

Another possibility is Pitolisant. Again, this is still in clinical trial from the post on longecity - basically a nootropic & brain drug forum with lots of people discussing ADHD meds, nootropics etc. Longecity isn't always correct but there are some very smart people on the site.
http://www.longecity.org/forum/topic/55110-pitolisant-when-will-the-trials-finish/

[Nightingale]

I know many of us have already tried antihistamines as a treatment for POIS, but how many have tried them along with Zantac (Ranitidine) or any other heartburn relief meds?  They too are technically antihistamines, acting on the H2 receptor.

I need to give myself some time before my next O, but I'm going to try taking both.

[haidcat]

I have tried both, they personally dont do much. Also, the H2 receptors are really only found in the gastrointestinal system and on the heart, not down in the genitals

[Vincent M]

I tried a few Ranitidine pills. I tried to use it similarly to how I would take benadryl or claritin (~1hr prior to orgasm), but it didn't help.

[kurtosis]

I have tried both, they personally dont do much. Also, the H2 receptors are really only found in the gastrointestinal system and on the heart, not down in the genitals

Whether a h2 anti-histamine is much good really depends on how bad your POIS symptoms are. If you get "racing heart" and stomach pain then perhaps it's useful. If not and it's primarily cognitive then rantidine wouldn't be much good. I found benadryl to be more effective than 2nd or 3rd generation antihistamines. Oddly, even though it should make me drowsy (and does somewhat) it appeared to help with some of the cognitive symptoms and I felt surprisingly smart if not particularly alert after an O. I have a few theories why this was the case.

Until h3 inverse agonists are available, it's difficult to test the theory of POIS activity on H3 receptors, except perhaps by comparing the mast cell stabilisers (which may reduce our desire to orgasm in the first place) and standard anti-histamines and that's quite a theoretical test.

[demografx]

I tried a few Ranitidine pills. I tried to use it similarly to how I would take benadryl or claritin (~1hr prior to orgasm), but it didn't help.

I take Ranitidine (generic for "Zantac"), it does a great job on my heartburn. Didn't realize anyone tried for POIS.

I used to take Benadryl to force naps...naps improved my POIS.

[kurtosis]

I have tried both, they personally dont do much. Also, the H2 receptors are really only found in the gastrointestinal system and on the heart, not down in the genitals

Whether a h2 anti-histamine is much good really depends on how bad your POIS symptoms are. If you get "racing heart" and stomach pain then perhaps it's useful. If not and it's primarily cognitive then rantidine wouldn't be much good. I found benadryl to be more effective than 2nd or 3rd generation antihistamines. Oddly, even though it should make me drowsy (and does somewhat) it appeared to help with some of the cognitive symptoms and I felt surprisingly smart if not particularly alert after an O. I have a few theories why this was the case.

Until h3 inverse agonists are available, it's difficult to test the theory of POIS activity on H3 receptors, except perhaps by comparing the mast cell stabilisers (which may reduce our desire to orgasm in the first place) and standard anti-histamines and that's quite a theoretical test.

http://en.wikipedia.org/wiki/Betahistine is a vertigo treatment and an inverse agonist of h3. My concern would be it's also an agonist of h1. So it might make some POIS symptoms worse.  If anyone is trying this, please check with your doctor.
It's a shame we can't get Ciproxifan but this http://en.wikipedia.org/wiki/Pitolisant looks promising.

[Nightingale]

http://en.wikipedia.org/wiki/Betahistine is a vertigo treatment and an inverse agonist of h3. My concern would be it's also an agonist of h1. So it might make some POIS symptoms worse.  If anyone is trying this, please check with your doctor.
It's a shame we can't get Ciproxifan but this http://en.wikipedia.org/wiki/Pitolisant looks promising.

I read about Betahistine.  There's a part at the end of that wiki article saying that a recent study for weight loss saw very few side effects.  You are right that we should be concerned since we have POIS.  I am going to talk to my doc about it.

[Nightingale]

Upon speaking with my primary care physician, he mentioned to me that if I were concerned about excess histamine I should take hot showers.  Supposedly the heat from the water would stimulate the skin and bring histamine there where it would be used up.  I thought this interesting, as I was unknowingly using this treatment for years as there was nothing that made me feel better than sitting and soaking in a hot shower.

A few days passed, and was going to have an O so I took my niacin and awaited the flush.  Then this idea came to mind: my skin flushing feels so much like getting a scorching hot bath.  The flushing feels pleasant in a similar way, washing over me.

Is there a connection?  I have not been able to find any study on hot showers reducing histamine, but my doctor told it to me like it was common knowledge among his peers.  He is an osteopathic doctor, by the way, and has been fantastic to me.

[Nightingale]

I found this book all about the H3 receptor on Google Play.  On sale for ONLY $216...  kurtosis, do you think you have access to this thru your work?

https://play.google.com/store/books/details?id=HJuzEwpF2-EC

[kurtosis]

I found this book all about the H3 receptor on Google Play.  On sale for ONLY $216...  kurtosis, do you think you have access to this thru your work?

https://play.google.com/store/books/details?id=HJuzEwpF2-EC

I couldn't even access it from my country I'll have a go using a proxy later today.

[Vincent M]

lol @ "ONLY $216". Love the sarcasm.

[demografx]

 

[LAPOISSE]

rosscb, excellent discussion, and great to see kurtosis' and CertainlyPOIS' remarks.

I found testosterone injectables stopped working for me. I've been told by my endocrinologist that patches and gel work much more "like the real thing", distributing T evenly throughout the body 24/7. Injections, he says, "spike" in and out of the system. I have been POIS-free about 3 years, via daily (365x) application of testosterone patches and antiinflammatory/mood meds.

Demo, what do you mean by "mood meds" ?

[demografx]

Ritalin, lorazepam, and controversial mild psychoactive Rx.

At different times, not in the same treatment period.

[demografx]

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Select as many months as you want! 2 months, 3 months, 4 months, 6 months, 12 months, whatever!  



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[demografx]

Very interesting theory...it makes a lot of sense for me
how many persons have recovered by taking testosterone ?..Hearing testimonies, it seems more efficient than desens

At least 6 forum members have reported some level of testosterone success.