Why taking L-methionine 500mg daily is bad?
I'm taking the methionine more often now. 500mg / day. I couldn't get enough from food it seems. As I've increased the dose I've felt better and calmer.
To explain the chemistry at work here. The basic formulas are the one for glycosis.
Glucose + 2 NAD+ + 2 Pi + 2 ADP → 2 pyruvate + 2 NADH + 2 ATP + 2 H+ + 2 H2O + heat
See
http://en.wikipedia.org/wiki/Cellular_respirationSo NADH helps increase ATP, see the Krebs cycle.
and (very roughly)
Methionine + ATP → SAM-e
You can think of SAM-e as a kind of universal methylator which assists in the methylation (donation of a methyl group ) to various neurotransmitters including histamine. Methylation is the first step in your body clearing histamine. The 2nd is deanimation and the 3rd is the conversion of the aldehyde byproduct into acetic acid. To achieve all this efficiently you need various B vitamin co-factors and healthy cellular energy (ATP).
Things which boost ATP are NADH and D-Ribose powder. Creatine donates a phosphate to ATP to help recycle the ATP that's created using NADH and D-Ribose. Some athletes combine Creatine and D-Ribose for a big energy boost.
So my sketch idea is the following.
- Lower histamine using methionine or SAM-e.
- Take b vitamins as they are required co-factors in many enzymatic reactions triggered by methylation. The v vitamin I take has coq10 as this is depleted in many illnesses and helps immune function.
- Increase ATP to help the body recover. If the histamine is caused by an underlying infection then the body has some chance of fighting it with more ATP. By adding NADH and D-Ribose from external sources (i.e. supplements) you're giving your body something that it would have to use precious energy to create. If high histamine is caused by a genetic defect in the methylation process then taking SAM-e should sort that out.
There are people who have made huge improvement in dealing with chronic fatigue syndrome by just adding NADH and/or D-Ribose. I hadn't thought of myself as chronically fatigued until I started taking NADH and D-Ribose and realised that there were lots of active things that I used to do that I had stopped because I felt tired. This is not normal for someone in their mid 30s. If you feel tired, don't want to go out etc. that's not normal and it's gotta be put right!
It wasn't always that way but this illness became worse since my late 20s and I think that has a lot to do with a decrease in hormone production and fatigue.
I think the reason why TRT works as a treatment is that POIS is actually something our body is continually fighting, which leads to inflammation and "cortisol steal". Untreated POIS would therefore naturally lower testosterone levels. It may be viral or it may be just a genetic inefficiency but the end result is that we end up being in an "allergic" state.
This does not mean that I think anyone is allergic to sperm. It's is 100% known that histamine is released during an orgasm anyway. The allergist I spoke to said she already had women patients with some allergic reactions following orgasm it's just that they're not that severe (but some suffer headaches, some get rashes, signs of nasal allergy etc.). She told me that
you don't need an allergy to sperm to produce histamine during an orgasm. A simple google confirms this.
It is also understood that the H3 histamine receptor will inhibit both histamine and the release of other neurotransmitters in the brain
This is why novel drugs like
http://en.wikipedia.org/wiki/Ciproxifan are being produced that threat attention disorders &/ dementia via the H3 receptor.
It has been suggested that testosterone may inhibit the allergic reactions in men so increased testosterone may lower histaminergic reactions but the occasional orgasm related rash or flush in some men does happen. What if POIS is just that but ramped up because we have too much circulating histamine ANYWAY?
The Raising ATP and lowering Histamine path is not a quick fix by any stretch of the imagination. It's giving the body a chance to recover and assisting the body's natural healing processes by giving the cells the thing they most need to heal (energy).
If you have high histamine and reduced ATP output, you may get infections. Increasing ATP output and reducing histamine may actually make you feel sicker for a few days (or even more than a week) like I felt during the anti-fungals.
People with above average levels of histamine are very driven apparently but, one of the problems with this, is that high-histamine types often have unrealistic expectations. For example, people who are taking SAM-e to reduce the effects of osteoarthritis inflammation don't expect to take it for a day or so and play professional soccer
But I can see numerous examples of people on NSF saying
"I took X and I had a bad orgasm so X obviously won't help with POIS". This is like predicting the average rainfall for the year based on one day
but it's symptomatic of our personalities and the neurotransmitter balance that produce POIS (and that includes histamine). It's one reason why doctors think we have anxiety disorders.
Some of us come into them with histories of what most people would consider solid or even outstanding academic achievement and say we have a serious physiological problem and can't think. In some cases, we're probably smarter and more driven than the doctors themselves. The doctor assumes you're nuts and doesn't question what genetic or physiological conditions may produce someone
who is clearly smart but knows they could be smarter if not for a problem that's holding them back. I believe the thing that's driving us to beat POIS may be the thing making us sick but it's not "psychological".
My own expectations involve looking at every week and seeing did I have more energy on average and did I function better in work. If I can't decide whether I improved or disimproved that week, I decide to be positive about it and assume it was better. The next trend is monthly. Daily trends tell me nothing.
