Mast Cell Activation Syndrome

[Muon]

The first year and this year, the problem arose when the weather became warmer

[Muon]

Landscape of mast cell populations across organs in mice and humans

[Muon]

Food for thought: Do certain mutations in mast cells define POIS?

Video: Root Causes & Treatment of Mast Cell Disease

Treatment comes down to trial and error in finding personal key(s) to the molecular lock(s) plus recognizing and avoiding triggers.

[Muon]

News letter

Hi,

On August 14th, Drs. Afrin and I, with one of our close collaborators, Dr. Gerhard Molderings (an internationally recognized expert in mast cell activation syndrome (MCAS) based at the University Hospital of Bonn), published an article in the journal Diagnosis discussing challenges in accurately interpreting results of tests in MCAS patients for levels of antibodies which mark for various infectious or autoimmune diseases.

While positive antibody tests in MCAS patients may not always indicate the presence of associated diseases, the immune system's chaotic response often leads to the production of inappropriate antibodies. Conversely, the immune system may fail to produce antibodies against actual infections, resulting in false negative results. Unfamiliar clinicians may misinterpret these results, leading to unnecessary treatment.

In this paper

Learned cautions regarding antibody testing in mast cell activation syndrome

we emphasize that understanding the significance of antibody tests in MCAS patients is best achieved by observing patterns of results over time. These patterns differ when MCAS is present, and alternative testing methods may also be useful for accurate diagnosis.

In critical situations, immediate treatment may be necessary based on a positive antibody test. However, in most cases, patients should work closely with their doctors to retest over time and establish a consistent pattern. This approach saves patients from unnecessary treatment or potential misdiagnoses.

These complexities with interpreting antibody test results are just one aspect of the intricate nature of MCAS.

To your best health,
Dr. Tania Dempsey

[Muon]

It’s been 2 weeks now that he’s going through pois. He said he’s feeling bad just by drinking water

[Muon]

News letter

Good morning,

Did you know that hormone imbalance is one of the top issues associated with Mast Cell Activation Syndrome (MCAS)?

Do you have any of these top symptoms of hormone imbalance?

Unexplained weight gain or weight loss
Fatigue
Higher-than-normal blood cholesterol levels
Depression or anxiety
Slow heartbeat or rapid heartbeat (tachycardia)
Extreme thirst and frequent urination
Hair loss
Excess body hair
Menstrual issues
Low libido

These are a few indicators that you might have a hormonal imbalance. Dysfunction of mast cells could exacerbate hormonal problems, but hormones can also act as a trigger for your mast cells.

If you have any of those or any other hormonal imbalance symptoms, then watch my interview with Beth O'Hara now.

https://www.youtube.com/watch?v=DQEHG1zvcJE

In this interview, you'll learn more about:

The most critical hormones in MCAS
How hormonal imbalances affect MCAS
What is a Psycho-Neuro-Endocrine-Immune condition?
Is MCAS considered a Psycho-Neuro-Endocrine-Immune condition?
The important order of operations for balanced hormones with MCAS
Dr. Dempsey’s top tips for rebalancing hormones

Want to learn more?

Join us at the Mastering Mast Cell Activation Summit, where you’ll learn all about MCAS symptoms, triggers, coexisting conditions, and what you can do now to start addressing your symptoms.

Find your path to healing when you attend this complimentary, online event!

Dr. Tania Dempsey

P.S. When you register for Mastering Mast Cell Activation, you’ll also unlock early-access interviews, complimentary guides and helpful eBooks exploring MCAS and how to get started on your healing journey.

[Muon]

Connective tissue mast cells store and release noradrenaline (2023)
https://jps.biomedcentral.com/articles/10.1186/s12576-023-00883-3

Our findings indicate that mast cells may play a role in regulating noradrenaline concentration by storing and releasing it in somatic tissues.

In addition to noradrenaline, mast cells take up various bioactive substances. For example, in the 1970s, it was reported that mast cells take up serotonin (5-hydroxytryptamine; 5-HT) into the cell [11]. In this study, we confirmed that noradrenaline-storing CTMCs express Oct3 (Fig. 5), which has been reported to take up histamine, serotonin, dopamine, and adrenaline into the cell, as well as noradrenaline

[Muon]

Improving neuropsychiatric conditions by Mast Cell-directed treatment.
Neuropsychiatric Manifestations of Mast Cell Activation Syndrome and Response to Mast-Cell-Directed Treatment: A Case Series (2023)

[Muon]

Mast Cells in the Autonomic Nervous System and Potential Role in Disorders with Dysautonomia and Neuroinflammation (2023)

Conclusion

The available evidence indicates that MC can affect ANS via a variety of actions such as activation of microglia and astrocytes, BBB disruption, cardiac peacemaking, circadian clock, coronary artery constriction, HPA axis regulation, neuroinflammation, neurosensitization and vascular tone control (Table 3), thus potentially contributing to a number of dysautonomias and neuroinflammatory conditions with dysfunctional homeostasis.

Key Messages

Mast cells are located close to blood vessels and neurons.

Mast cells secrete many vasoactive and neurosensitizing mediators without histamine or tryptase.

Mast cells can affect and be affected by the autonomic nervous system.

Mast cells could contribute to dysautonomias and neuroinflammation.

There is a need for development of effective inhibitors of mast cell activation.

[Muon]

I recently received the results of an evaluation that included my Chromogranin A (CgA) value, and I wanted to update you on it. It turns out that my CgA level is [L225 ng/mL], which is higher than normal.