In my current method, I use 3 NMDAR blockers ( magnesium, flax seed oil and L-theanine/green tea) that help reduce the excitotoxicity in the brain by blocking the NMDA receptors, so whatever the agonist is, the receptor is blocked. I also use IDO and TDO inhibitors, that prevent the production of the toxic metabolites I suppose are at play in the brain while in POIS. The reasons I state are only a hypothesis, but however, my pre-pack of supplements works for me, whatever the exact scientific reasons may be.
Hi Quantum,
I read about your pre-pack, I don't know if I interpret this article right.
http://www.ncbi.nlm.nih.gov/pubmed/17230642#
But could perhaps creatine among the other things mentioned in this article be interesting for use in the pre-pack ?
Hi erik !
Good point, creatine has indeed NMDAR blocker properties. I have tried it a few times, a few months ago, but even at low dose, it makes may urinate at a very high frequency for several hours ( up to 24 hours for a single dose), so it was not worth it for me, because of this particular side effect it has for me. The mechanism of this increased urination may be osmotic diuresis, I suppose, since creatine is a very small molecule, and can cause this in the kidney tubules. This effect is not often mentioned, but I did have found other cases of this mentioned on the internet, often on forums by body builders that have tried using it.
Since I have already other NMDAR blockers that work well without side effects, I have let go of creatine. It may be useful for other POIS sufferers, as it is usually well tolerated. If anyone get good results with it, let me know.
