POIS Cause/Treatment Discussions > General Alternative Causes and Treatments of POIS

Stumbled onto something potentially huge!

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This theory already has some backing here:https://sites.google.com/site/poiswebsite/test-page/orgasm-induced-catecholamine-imbalance-via-pituitary-dysfunction
Ive got a theory here, that might explain alot of symptoms of POIS, and why niacin/continual vitamin b complex supplmentation is working for alot of us. To make it short, POIS could be a debilitating reaction to a massive adrenaline surge during orgasm. This reaction can last for DAYS, yes days. Hyperadrenergic disrorders are different from just plain stress/anxiety, in that it really is an overload of pure adrenaline coursing through your veins that can be caused by orgasm, eating, running, etc. Many patients who have hyperadrenergic POTS, report that it can sometimes take days to recover from an adrenaline surge episode, and the symtpoms include dizziness, brain fog, muscle pain, palpitations, dry mouth, digestive problems....

And guess what vitamin b3 has been shown to be really good for??? thats right, adrenaline surges... Look at this quote, "Accordingly, they decided to use high doses of niacin, another natural methyl acceptor, to reduce the conversion rate of noradrenaline to adrenaline and then to adrenochrome. Double-blind controlled experiments conducted on acute schizophrenics with high doses of niacin (usually 3 to 6 g daily) were very successful, outperforming the then conventional treatments and reducing suicide rates.26 Niacin can lower the body's production of adrenochrome and its derivatives."-Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD, Feel Better, Live Longer with Vitamin B-3

As to how Niacin could be specifically working for this problem: Niacin is a known methylacceptor(it grabs and steals methyl groups). Adrenaline is made from norepinephrine by the addiion of a methyl group. Therefore the niacin protection could be clocking the conversion of norepinephrine to adrenaline, protecting people from the adrenaline surge, and also probably preventing a relative defieincy in noreinephirine( a neutotransmittor heavily involved with depression, lack of concentration, brain fog, etc, if there is a lack of it).

In sum, the vast majority of us could be dealing with a hyperadrenaline episode during orgasm, which can last for days, and which would make a lot of sense as to why niacin works for up to several hours(its blocking the massive adrenaline surge). To those who are not helped by niacin/b complex.... it very well could be an allergic response, or something else entirely...OR you could have a hyperadrenaline disorder which gets triggers NOT ONLY by orgasm, but by eating, sleeeping, exercising etc, hence the constant POIS.

Just food for thought on the issue :)

As an addendum: look at this link for the symptoms of something called POTS(a condition characterized by rapid heart beat due to adrenaline problems)- http://potsweb.50webs.com/

Symptoms include: flu-like feeling, fatigue, palpitations, digestive problems, feeling of pressure behind the eyes, aching muscles, urinate frequently..... the list goes on and on...

I also want to add, that this theory does not have to contradict the allergy theory. It very well could be that the activation of mast cells by semen in the urethra triggers a hyperadrenal episode, and that the most debilitating symptoms of POIS come from the fatigue of an adrenal episode AND a temporary defiency in Norepinephrine, while the nasal congestion, red eyes, and sneezing come from the pure allergy component of the problem.

Testosterone has helped several of us. Does this treatment fit your adrenaline surge theory? Thanks.

Look at this article on rat hearts, testosterone inhibits the release of norepinephrine into rat hearts, meaning it prevents it from reaching the heart where it eventually converts to adrenaline causing the surge: http://www.unboundmedicine.com/medline/ebm/record/22282243/abstract/Effects_of_testosterone_on_norepinephrine_release_in_isolated_rat_heart_

Also this: http://www.ncbi.nlm.nih.gov/pubmed/6684059

Testosterone makes u pee out norepinephrine(by making the kidneys build it up and excrete it), preventing the surge because norepinephrine is the precuroser to adrenaline: http://hyper.ahajournals.org/content/32/5/880.full

This theory explains why niacin works(prevents the conversion of norepinephrine to adrenaline), why testosterone works(it has been shown to block the adrenaline precursor,norepinephrine, release from cells along with making you pee out adrenalines precursor). It also explains why antidepressants/high protein have worked for some, it could be replinishing the neurotransmittor precursors to adrenaline, that are heavily depleted after the orgasm surge. Also this explains why a low glycemic diet works for some.... adrenaline and cortisol play a massive role in hypoglycemia, indeed, some of the terrbile symptoms from a hypoglycemic episode come from the massive adrenaline surge. Combine someones hypoglycemia with the rigours of an orgasm, and u could easily have terrible symptoms.

In effect, we could have something going on here very similar to  hyperadrenergic POTS(postural orthostatic tachycardia syndrome) except that instead of getting a massive norepinephrine release into our blood (which converts to adrenaline) upon standing...... we get it upon orgasm.

Theoretically beta blockers before orgasm should do the same thing as niacin, so it can be tested in this theory. BUT, niacin prevents conversion of norepinephrine to adrenaline, while beta blockers just blockadrenaline after its made. So niacin could be preventing adrenaline surges+ preventing adrenaline precursor neurotransmittor deficiencies, while beta blockers would only prevent the surge.


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