A new take on Silodosin

[Physi]

Hi everyone,

I have been experimenting Silodosin recently, because I have seen topics about it and because of the study of Yacov Reisman, reporting 57% success in treating POIS with silodosin (you can find attached a diagram summing up the study).

I have read every post of Poisers using silodosin on Reddit, pois center and the naked scientist.

What I have found myself and in many topics by many POISers is that silodosin works 100% in preventing ejaculation when orgasming and thus 100% in preventing POIS symptoms. Taking 8 mg daily before sleeping, I had NE?s but without ejaculation and without POIS (Silodosin held sperm inside).

But after about 3 weeks it stops working and thus it has never become a universal treatment.

Most of the POISers that have had that experience concluded that after 3-4 weeks of semen retention, there was too much sperm for silodosin to hold it.

However, I do not believe that because :
1) Semen production is auto regulated by the body
2) I have myself been on semen retention for 4+ months using ejaculation free orgasm (I will not discuss that here as it is not the subject of the topic) and Silodosin worked in the beginning for me as well

Furthermore, after 4 weeks of daily Silodosin, I had an interrupted intercourse (without ejaculating in the end) as I have regularly and for the first time in my life I had POIS due to it.

I think that Silodosin weakens the pelvic floor leading to sperm leakage even when not orgasming with arousal or interrupted intercourse. That would also be the reason why Silodosin stops working after a while.

Also it would be the reason why some Poisers have POIS from arousal whereas most of them have POIS only from an intercourse. It may be because their pelvic floor is weak, leading to sperm leakage with arousal.

If it is the reason, Pelvic Floor can be strengthened with Kegel exercises and it would compensate the Silodosin effect.

Silodosin has shown success for many members and is a 100% relief method, so I think it would deserve a second shot to find out why it stopped working for everyone using it. Also it is a very successful method to prevent NE.

Please give feedback if you have some insight about that !

[Physi]

After some research it is not directly the pelvic floor muscles that are affected :

How Silodosin Can Cause Semen Leakage Outside of Ejaculation :

Silodosin is an alpha-1A adrenergic receptor blocker primarily used to treat symptoms of benign prostatic hyperplasia (BPH). It works by relaxing smooth muscles in the prostate, bladder neck, and urethra, which helps improve urine flow. However, this same mechanism can lead to unintended effects on the bladder neck and seminal pathways, including semen leakage outside of ejaculation.

1. Normal Ejaculation Process (Without Silodosin)
   ?   During ejaculation, smooth muscles in the bladder neck contract to close off the bladder, preventing semen from entering it.
   ?   Simultaneously, the seminal vesicles, prostate, and vas deferens contract, pushing semen through the urethra and out of the penis.
   ?   The bladder neck acts as a gatekeeper, ensuring semen is directed outward.

2. How Silodosin Affects This Process
   ?   Silodosin relaxes the smooth muscles in the bladder neck and prostate by blocking alpha-1A receptors.
   ?   This relaxation prevents the bladder neck from closing properly during ejaculation or even in a resting state.
   ?   As a result:
   ?   The natural ?gatekeeping? function of the bladder neck is weakened.
   ?   Semen can leak backward into the bladder (retrograde ejaculation) or dribble out involuntarily through the urethra, even without sexual stimulation.

3. Why Semen Leakage Can Happen Outside of Ejaculation
   ?   Normally, small amounts of pre-ejaculatory fluid (produced by Cowper?s glands) are released during sexual arousal.
   ?   With the bladder neck relaxed, this fluid?or even small amounts of seminal fluid?can escape more easily through the urethra without the normal pressure or control mechanisms.
   ?   This can result in involuntary leakage of seminal fluid or pre-ejaculatory fluid at unexpected times, such as during physical exertion, bowel movements, or even without obvious triggers.

4. Key Factors Leading to Semen Leakage with Silodosin:
   1.   Bladder Neck Dysfunction: Failure to close properly allows fluids to pass freely.
   2.   Decreased Resistance in the Urethra: Relaxation reduces the natural pressure barrier.
   3.   Lack of Proper Muscular Contraction: Smooth muscles in the bladder neck lose their ability to hold fluids in place.

5. Is This Permanent?
   ?   No, the effect is reversible. Once Silodosin is discontinued, the bladder neck typically regains its normal function.

6. Summary:
   ?   Silodosin relaxes smooth muscles in the bladder neck and prostate.
   ?   This relaxation weakens the natural ?seal? of the bladder neck.
   ?   As a result, semen or pre-ejaculatory fluid can leak involuntarily through the urethra, even without ejaculation.
   ?   This is primarily due to the loss of muscle tone and control in the bladder neck.

I believe that that passage of seminal fluid is the reason of POIS here. I wonder if it can be compensated with kegels.

[b_jim]

Do you think strength of ejaculations may influence the intensity of symptoms ?
(for another reason I consider my ejaculations as "strong" :/ )

I remember some guys use myorelaxant (tetrazepam) with success.


Very good job anyway 

[Physi]

Do you think strength of ejaculations may influence the intensity of symptoms ?
(for another reason I consider my ejaculations as "strong" :/ )

I remember some guys use myorelaxant (tetrazepam) with success.


Very good job anyway 

Hi b_jim,

Thanks.

If I have a dry orgasm I have no symptoms at all, if not I have symptoms.

I don't think ejaculation strength have to do with silodosin as I had strong ejaculations and still a dry orgasm with silodosin.

The only reason I stopped silodosin is that leakage that occured after about 3 weeks of taking silodosin. It's a shame because I had 0 symptoms in the beginning when orgasming on silodosin.

I have tried dry orgasm by manually blocking the flow of semen and it worked as well (I documented that method in another post), but I do not master that technique enough to perform it well each time.

So for me dry orgasm = no POIS.
It's also the case for many other Poisers (many Poisers on the forum experienced it).

It's really a shame Silodosin causes that leakage, I hope there is a way to make Silodosin work on the long term with kegels or another method. Lots of people have experimented success with silodosin, but only for about 1 month.