Author Topic: Great success using antihistamine Lergigan, FODMAP free oral solution  (Read 2135 times)

Meshal

  • Jr. Member
  • **
  • Posts: 66
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #20 on: August 29, 2024, 01:19:52 PM »
Wow, I have to say I didn't expect it to work, but it did, and it was a massive success. If I wasn't required to take it before each orgasm, I'd even call it the ultimate cure for POIS.

For my trial, I used Rhinathiol Promethazine (liquid), with a dosage of 7.5mL to 10mL. Luckily, it's available at any pharmacy in my area without a prescription for as little as $2 USD.

My main POIS symptoms are both cognitive and physical: brain fog, short-term memory loss, intense fatigue, and inflammation lasting for about 3 days.

I took my first dose on August 9th, and an hour later I had an orgasm. And like you said, 0 POIS symptoms. The following day, I felt the physical symptoms, but they were minimal, only about 25% of the usual pain. And they only last for 2 days but I wasn't really feeling it that much compared to the usual pois. I suspect this might be partly due to my poor physical health, as POIS has kept me from working out and eating healthy for years. I imagine that with a regular workout routine, along with fenugreek and beetroot, the physical symptoms would cease to exist.

The best part is my brain functions remains fully intact, and it stays like that permanently, no time limits. No more waking up the next day post orgasm wondering what I did yesterday. It really feels like a protective shield for my brain. I've even returned to work at full performance after years of being on hiatus.

In my case, when I take it even 5 mins post orgasm, it won't work. It has to be explicitly 45-60 mins before orgasm. I still orgasmed like two or three times it still wouldn't make a difference in my symptoms, which is most impressive. even if I delayed my orgasm like 80-100 mins after my dose it would still work.
I've tried Niacin in the past, but it only managed to alleviate the physical symptoms. I still struggled with brain fog, and it was challenging to stay in a flushed state for it to work.
But with Promethazine, you just take the dose, wait an hour, and that's it. I do still experience an intense headache about three hours after the dose, lasting for two hours. I found that taking more than 8mL causes intense anxiety and headache, even when taken at night, it can still make sleeping super hard for a few hours. So I found my sweetspot to be 7.5mL, your mileage may vary.
This has genuinely transformed my life and perspective. After years of suffering, I can finally live POIS-free. I no longer have to worry about the symptoms, which used to hinder every aspect of my life.

I'm now even more curious about how it actually works to prevent my symptoms. How did you come to the conclusion that this might work?was it advice from a doctor or something you discovered through research?

I've been taking it for 3 weeks now, (I orgasm 3-4 times each week, so that's 3-4 doses) I've waited this long before posting to verify that it is not some placebo effect. No issues so far.
I'll never forget this post, and your name, Mike. From the bottom of my heart, thank you :)
« Last Edit: August 30, 2024, 09:11:19 AM by Meshal »

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #21 on: August 30, 2024, 03:52:02 AM »
Hi there,

Thanks for sharing your experience.
Could you tell me if you have to take this for like a week so it's in your system before you use it before sex?

Thanks
Neil

Hopeoneday

  • Hero Member
  • *****
  • Posts: 962
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #22 on: August 30, 2024, 12:26:50 PM »
I'm now even more curious about how it actually works to prevent my symptoms. How did you come to the conclusion that this might work?was it advice from a doctor or something you discovered through research?

It can cross blod brain barier (and protect CNS from POIS damaging,
my conclusion), it also antycholingeric, blocks the actions of acetylcholine.
This old types of antihistamines is tesded a long time on pois forum from mebers, me personaly didn,t react well on benadryl replacemant,
but i will tested again.
« Last Edit: August 30, 2024, 03:02:22 PM by Hopeoneday »
Dr-pois.

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #23 on: September 05, 2024, 12:09:57 PM »
I've had mine delivered today. Dreading it. I've not O in 3 months. I'm praying this work🙏 x

Muon

  • Hero Member
  • *****
  • Posts: 3102
    • MCAD Thread
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #24 on: September 05, 2024, 02:31:45 PM »
I've had mine delivered today. Dreading it. I've not O in 3 months. I'm praying this work???? x
Prescription? If not, where did you order it from?

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #25 on: September 05, 2024, 02:41:52 PM »
Medsforless.co.uk

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #26 on: September 10, 2024, 01:14:46 PM »
I've had mine delivered today. Dreading it. I've not O in 3 months. I'm praying this work???? x
Prescription? If not, where did you order it from?

Did you get any Muon?


Muon

  • Hero Member
  • *****
  • Posts: 3102
    • MCAD Thread
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #27 on: September 10, 2024, 01:20:51 PM »
No, I'm testing diphenhydramine at the moment.

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6355
  • All of us working together to defeat POIS!
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #28 on: September 10, 2024, 01:39:04 PM »

…I'm testing diphenhydramine at the moment.


Diphenhydramine worked minor miracles for me after my open heart surgery 12 yrs ago.

Unfortunately, I became addicted to it and even wound up in the ER/extended stay/hospital observation for excessive dosage use.

Nevertheless, I continued taking it in spite of *multiple* MD (primary care + specialists’) warnings - - warnings to avoid it - - even at moderate doses.

I’m now off it, and feel better for it. But my primary concern (cognitive impairment) might not be the same as yours.

A Harvard health study:
https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667
« Last Edit: September 15, 2024, 12:11:11 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #29 on: September 10, 2024, 10:39:22 PM »

No, I'm testing diphenhydramine at the moment.


Diphenhydramine worked minor miracles for me after my open heart surgery 12 yrs ago.

Unfortunately, I became addicted to it and even wound up in the ER/extended stay/hospital observation for excessive dosage use.

Nevertheless, I continued taking it in spite of *multiple* MD (primary care + specialists’) warnings - - warnings to avoid it - - even at moderate doses.

I’m now off it, and feel better for it. But my primary concern (cognitive impairment) might not be the same as yours.

A Harvard health study:
https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667



How are you getting on with it?

Huser

  • Newbie
  • *
  • Posts: 38
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #30 on: September 16, 2024, 01:51:54 PM »
If I am wright that POIS is overactivation of dopamine d3 receptors, than lergigan should realy work. Because lergigan (Promethazine) works as a direct antagonist at the mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain.

Huser

  • Newbie
  • *
  • Posts: 38
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #31 on: September 16, 2024, 01:57:05 PM »
That means it will directly block overactivation of dopamine receptors at orgasm and protect against overexpression of glutamate in the brain that causes neuropathic and psychiatric problems.

Huser

  • Newbie
  • *
  • Posts: 38
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #32 on: September 16, 2024, 02:07:32 PM »
This drug also promotes epileptic seizures that I have. So be carefull...

Meshal

  • Jr. Member
  • **
  • Posts: 66
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #33 on: September 17, 2024, 06:32:55 AM »
That means it will directly block overactivation of dopamine receptors at orgasm and protect against overexpression of glutamate in the brain that causes neuropathic and psychiatric problems.

Very Interesting. Are you suggesting that POIS patients exclusively have to avoid overactivation of dopamine during orgasm in order to protect themselves from the cognitive POIS symptoms? Meaning that for regular people, overactivation of dopamine during orgasm is perfectly fine?

freddie

  • Newbie
  • *
  • Posts: 19
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #34 on: September 18, 2024, 10:59:50 AM »
I've had mine delivered today. Dreading it. I've not O in 3 months. I'm praying this work🙏 x

How did it work for you Cosmic?

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #35 on: September 19, 2024, 12:27:33 AM »
I've had mine delivered today. Dreading it. I've not O in 3 months. I'm praying this work🙏 x


Hi, I've not tried it yet mate. I've been O free for 3 months and shut scared I'm going to turn back into thar other person.

How did it work for you Cosmic?

freddie

  • Newbie
  • *
  • Posts: 19
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #36 on: September 19, 2024, 06:07:34 AM »
Hi, I've not tried it yet mate. I've been O free for 3 months and shut scared I'm going to turn back into thar other person.
I understand.
from your reply i wonder whether you get symptoms that last more than a few days. For me the symptoms can last for months..

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #37 on: September 19, 2024, 06:49:14 AM »
Hi, I've not tried it yet mate. I've been O free for 3 months and shut scared I'm going to turn back into thar other person.
I understand.

from your reply i wonder whether you get symptoms that last more than a few days. For me the symptoms can last for months..

Ah mate that sucks I feel for you, mine use to last for months but slightly changed my diet and  now it has reduced to 2 - 3 weeks.

Cosmic1982@

  • Newbie
  • *
  • Posts: 18
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #38 on: September 27, 2024, 04:23:10 AM »
Hi, I've not tried it yet mate. I've been O free for 3 months and shut scared I'm going to turn back into thar other person.
I understand.


from your reply i wonder whether you get symptoms that last more than a few days. For me the symptoms can last for months..



Well I tried it mate and guess what. Back to square one. Now another 2 weeks for me to find myself again.

mike_sweden

  • Sr. Member
  • ****
  • Posts: 286
Re: Great success using antihistamine Lergigan, FODMAP free oral solution
« Reply #39 on: October 01, 2024, 09:32:16 AM »
Hi, I've not tried it yet mate. I've been O free for 3 months and shut scared I'm going to turn back into thar other person.
I understand.


from your reply i wonder whether you get symptoms that last more than a few days. For me the symptoms can last for months..



Well I tried it mate and guess what. Back to square one. Now another 2 weeks for me to find myself again.

That's interesting to hear, for me it work miracles, no issues at all.
What dose and how long time before orgasm did you take it?
Was it the oral, FODMAP free solution?