Author Topic: Important evidence d3 and NMDA receptors  (Read 1974 times)

Huser

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Important evidence d3 and NMDA receptors
« on: August 04, 2023, 02:40:18 PM »
Hello, I have found evidence for my POIS. Here are my datas:

After I tried Mirapexin (Pramipexole - dopamine agonist) and got same symptoms as with orgasm,  it is pretty clear that my symptoms start when my levels of dopamine get high. Connecting this information with diseases of my mother and grandmother (schizophrenia), I have strong evidence that my problem is:

OVERSTIMULATION OF  DOPAMINE D3 RECEPTORS IN HIPPOCAMPUS AND STRIATUM, WHICH LEADS TO EXCESSIVE GLUTAMATE RELEASE IN THE SAME PART OF THE BRAIN. 

Glutamate activates NMDA receptors or simply my chronic pain, which I got with infection when I was teenager.  Escalating levels of glutamate can lead to overactivation of NMDA receptors, which leads to pain syndrome that I got with Mirapexine and antibiotic Ciprofloxacine, lasting for 2-3 years. When NMDA receptors are overactivating I can trigger my symptoms/pain with sitting, reading and walking.

Orgasm - increases dopamine, than drops fast (will not drop so fast if you have POIS)
Mirapexin (dopamine agonist) - increases dopamine with stimulating d3 receptors
Schizophrenia (my mother, my grandmother)- the main cause is believed to be a gene DRD3, that is encoding dopamine receptor D3


High levels of dopamine increases striatal glutamate.

My EEG  is abnormal:
Sharp bursts of Theta waves in centrotemporal part of the brain - Theta waves derive from hippocampus, showing it is overactive like schizophrenic hippocampus. Theta waves affecting centrotemporal part, showing they are the reason for affecting my chronic pain. (Chronic pain connected with centrotemporal part of the brain).

My pain progressed into restless leg syndrome, shows that caudate nucleus was affected. Caudate nucleus is strongly conected with hippocampus.



Medications:
Doctor suggested me:

Duloxetine (antidepressant medicine known as a serotonin-noradrenaline reuptake inhibitor) - enhances glutamatergic activation, but not dopaminergic,, thats why I think it is not perfect for POIS.

Pregabaline (anticonvulsant, analgesic and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal and generalized anxiety disorder) - inhibiting certain calcium channels, thats why I think it would work for POIS like Carbamazepine helped in this topic https://poiscenter.com/forums/index.php?topic=4271.msg45771#msg45771. It means it blocks NMDA receptors. Also inhibiting dopamine and glutamate.

Cariprazine ( atypical antipsychotic medication indicated for the treatment of schizophrenia and bipolar mania) - Cariprazine acts to inhibit overstimulated dopamine receptors (acting as an antagonist), it means I would have to take this medication for whole my life, just to have normal sex. Side effects are worse as POIS, so I think it's not worth it.

I WONT TRY ANY OF THIS MEDICATIONS, BECAUSE OF PAST BAD EXPERIENCE!

You can try to check my theory with alcohol. Alcohol blocks NMDA receptors. If you drink alcohol before sex, you wont get POIS symptoms after sex. This works only once or twice in a short time (cca. 1 week)! If you do that often it wont work and POIS will get worse, because with alcohol you block only NMDA receptors and not dopamine and glutamate release, which are the main cause of your problem. Excessive glutamate will than activate your NMDA receptors (symptoms) even after light physical activity!



Huser

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Re: Important evidence d3 and NMDA receptors
« Reply #1 on: August 04, 2023, 02:53:22 PM »
If you check diseases connected with hyppocampus and striatum dysfuntion, you can see all of this diseases are part of our POIS center topics.

That why I think POIS is just a syndrome of:

Depression, Schizophrenia, Epilepsy, Parkinson s, Bipolar disorder, Chronic pain, Chronic fatigue syndrome....

Quantum

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Re: Important evidence d3 and NMDA receptors
« Reply #2 on: August 04, 2023, 08:28:12 PM »
I have been using some NMDA blockers for years, and they help with my symptoms.  I use magnesium, and also flaxseed oil because it contains lignan, a NMDA blocker ( https://pubmed.ncbi.nlm.nih.gov/22970936/).

They are not enough on their own to control my symptoms, but are part of my solution.
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Huser

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Re: Important evidence d3 and NMDA receptors
« Reply #3 on: August 05, 2023, 01:22:31 AM »
As I said, NMDA blockers hide pain or other symptoms, but they wont block dopamine and glutamate release. So If you block NMDA receptors too many times, orher two neurotransmiters can become abundant and start causing big problems.  You can become addicted with NMDA blockers then. It is better to avoid things that trigger POIS and use NMDA blocker rarely and carefuly.

demografx

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Re: Important evidence d3 and NMDA receptors
« Reply #4 on: August 05, 2023, 02:43:48 PM »
I have been using some NMDA blockers for years, and they help with my symptoms.  I use magnesium, and also flaxseed oil because it contains lignan, a NMDA blocker ( https://pubmed.ncbi.nlm.nih.gov/22970936/).

They are not enough on their own to control my symptoms, but are part of my solution.

Quantum, would it make any sense for me to experiment with your solution (link, please?) in addition to my less-than-100%-successful testosterone treatment for my POIS?

Maybe I’ll ask my new POIS doctors?
« Last Edit: August 05, 2023, 03:53:46 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Huser

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Re: Important evidence d3 and NMDA receptors
« Reply #5 on: August 14, 2023, 12:57:32 PM »
Sorry for late answer. Your new POIS doctor was on a vacation.

I apologize for not mentioning testosterone treatment. I forgot about it.

If you read scientific literature carrefuly you can see testosterone is very important for healthy hippocampus  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931212/

If you read further you can see, testosterone decreases d3 receptors: https://pubmed.ncbi.nlm.nih.gov/24618531/

This means testosterone would probably help me to decrease my  overactive d3 receptors and this could also be the sign that you have overactive d3 receptors.

It also means that if you want to have regular sex and you dont care about testosterone side affects (feftility and cardio vascular problems), than testosterone is fare better choice as NMDA blockers. If you choose NMDA blocker they will help only short time, than you have to stop taking them. Try alcohol carefully.

Testosterone also helps fybromyalgia and chronic fatigue syndrome https://www.sciencedirect.com/science/article/pii/S1567576915002490

I hope someone is happy we found some evidence, cinic answers leave for other forums.