Free Flow Discussion about POIS

[demografx]

Just for clarification: Is this [your set of cognitive POIS symptoms] with or without your TRT usage? :-)

Both. With TRT/daytime sleep aids,  symptoms are drastically reduced. From suffering POIS agony for 4 days pre-TRT, to as little as hours today.

Pre-TRT, POIS symptom intensity was also far greater.

berlin1984, thanks, great question.

[drop247]

Demo did you also have great success with TRT without the antihistamine sleep aids?

[demografx]

I’ve been on TRT for 11 years now. It’s always been my primary treatment method. Early years without Benadryl or Tylenol worked well. “Great”? Maybe more so in the beginning years. I’m looking forward to 100% cure. Not sure I’ll find it in my lifetime (I’m in my senior years).

[drop247]

Thanks I trialed hCG monotherapy but failed due to high estradiol side effects like anxiety. I'm going to see about Testosterone therapy next and perhaps low dose hCG to maintain fertility once I have the Test dosage dialed in with estradiol under control. The energy I experienced at the beginning of the hCG therapy before estrogen got out of control was exciting.

[demografx]

Best wishes, drop247!

[demografx]

My physical POIS symptoms are easier to describe than my cognitive POIS symptoms.

My physical symptoms: extreme exhaustion, dry fingertips

My cognitive symptoms:
the first day is usually the worst. My creative juices dry up. Nothing is exciting. I’m depressed, but in a way that’s difficult to describe. My emotions are flat. My decent sense of humor and my memory, concentration and my ability to smile, to appreciate beauty go right out the window. And the surreal symptom that’s most difficult to describe:

Just for clarification: Is this [your set of cognitive POIS symptoms] with or without your TRT usage? :-)

Both. With TRT/daytime sleep aids,  symptoms are drastically reduced. From suffering POIS agony for 4 days pre-TRT, to as little as hours today.

Pre-TRT, POIS symptom intensity was also far greater.

berlin1984, thanks, great question.

This is NOT my endorsement or recommendation for anyone else with POIS to try TRT! A good POIS treatment is between you and a trusted doctor. My preferred treatment can be unacceptably risky for many POISers.

[Hopeoneday]

Happy Christmas to all

[demografx]

From Admin/Moderator team

To all Forum Members
& POIS Research Team

[demografx]

My physical POIS symptoms are easier to describe than my cognitive POIS symptoms.

My physical symptoms: extreme exhaustion, dry fingertips

My cognitive symptoms:
the first day is usually the worst. My creative juices dry up. Nothing is exciting. I’m depressed, but in a way that’s difficult to describe. My emotions are flat. My decent sense of humor and my memory, concentration and my ability to smile, to appreciate beauty go right out the window. And the surreal symptom that’s most difficult to describe:

Just for clarification: Is this [your set of cognitive POIS symptoms] with or without your TRT usage? :-)

Both. With TRT/daytime sleep aids,  symptoms are drastically reduced. From suffering POIS agony for 4 days pre-TRT, to as little as hours today.

Pre-TRT, POIS symptom intensity was also far greater.

berlin1984, thanks, great question.

This is NOT my endorsement or recommendation for anyone else with POIS to try TRT! A good POIS treatment is between you and a trusted doctor. My preferred treatment can be unacceptably risky for many POISers

Example: taking the testosterone prescribed by my endocrinologist - -
my sperm count went to 0.00

Yes, I am now *infertile*

[demografx]

It all started here on February 18th, 2007, when forum member John21 posted at our predecessor forum, the Naked Science Forum’s POIS thread.
https://www.thenakedscientists.com/forum/index.php?topic=6576.new#new

We would all still be there today, but the owner of the Naked Science Forum’s POIS thread would not allow us to conduct internal member fundrai$ing for what is now the 2022 POIS Research Study:
https://poiscenter.com/forums/index.php?topic=3006.0

Million thanks, everyone - - old and new - - for making this the #1 forum on the internet for POIS!

I especially want to thank Quantum, my co-administrator, for being tremendously valuable and instrumental in raising greatly the level of scientific accomplishment - - including outreach to the medical community at large - in finding a solution to this misery we all call POIS!

Best wishes everyone for a Great Future in POIS discovery through forum teamwork!

[Limejuice]

Well said Demo! A big thank you is in order to you, Quantum, Berlin, every contributor who has posted, and every reader who is trying solve this mystery.  We hope that our strength and numbers continue to grow in our 16th year!

[demografx]

Many thanks, Limejuice!

[demografx]

Well said Demo! A big thank you is in order to you, Quantum, Berlin, and Limejuice! , every contributor who has posted, and every reader who is trying solve this mystery.  We hope that our strength and numbers continue to grow in our 16th year!

Mod edit

[demografx]

Well said Demo! A big thank you is in order to you, Quantum, Limejuice, and berlin1984! , every contributor who has posted, and every reader who is trying solve this mystery.  We hope that our strength and numbers continue to grow in our 16th year!

Another mod edit

[demografx]

Well said Demo! A big thank you is in order to you, berlin1984, [Limejuice], and Quantum! , every contributor who has posted, and every reader who is trying solve this mystery.  We hope that our strength and numbers continue to grow in our 16th year!

Yet another mod edit

[demografx]

Quantum, you once recommended a Waldinger link to show my physician(s) an “intro” to understand POIS.

It was excellent! But I misplaced it and want to show another of my physicians.

I’m trying to convince him to prescribe Gabapentin for my POIS symptom of “fingertips feeling dry and aggravated” during POIS.

[Quantum]

Quantum, you once recommended a Waldinger link to show my physician(s) an “intro” to understand POIS.

It was excellent! But I misplaced it and want to show another of my physicians.

I’m trying to convince him to prescribe Gabapentin for my POIS symptom of “fingertips feeling dry and aggravated” during POIS.

Here it is:  http://tau.amegroups.com/article/view/11107/11778

[demografx]

Quantum, you once recommended a Waldinger link to show my physician(s) an “intro” to understand POIS.

It was excellent! But I misplaced it and want to show another of my physicians.

I’m trying to convince him to prescribe Gabapentin for my POIS symptom of “fingertips feeling dry and aggravated” during POIS.

Here it is:  http://tau.amegroups.com/article/view/11107/11778

Many thanks, Quantum!

Other forum members might want to use this
above link to show to their physicians what POIS is all about - - for doctors who know nothing about POIS

[ozmoses]

A fellow suffered messaged me regarding my regimen and I thought I'd share this info below.

"Hi there.  While I've seen at least 50% improvement in symptoms, I still have a way to go.

I have a pretty extensive regimen and the core of it is addressing acetylcholine related imbalance.

I have low acetylcholinesterase levels (AChE) (I have blood tests supporting this) and this presents a unique problem which may be relevant for many of us dealing with POIS.

I'd recommend getting tested for this as it could save you some time/trouble either way and it's cheap.

https://www.ultalabtests.com/testing/search?__RequestVerificationToken=D3sk4rUwi28j0Lq6d43ylFTnJ_2N0cnY_J9o6wTEiAIkCBuIC-hOB7lCh2_8C9X4FC-V4kTcAsjaefTmxaB4mYfLXJA1&ItemName=cholinesterase


I take the h1 antihistamine chlorpheniramine and historically that's been very helpful- it has anticholinergic properties (lowers/blocks acetylcholine).  Benedryl and hydroxizine also have anticholinergic properties, but don't appear to have the same SSRI type benefits as chlorpheniramine.  I have to take oxybutynin or glycopyrrolate which are stronger anticholinergics and they do have their own unique side effects like blurry vision, photo sensitivity, etc. but they do reduce sweating and some of the cholinergic crisis type symptoms of POIS.    I also take famotidine which is usually taken for acid reflex, but it has good antiinflammatory benefits.  I like the flavanoid Luteolin and take DAO (histamine blocker)enzymes as well.  Black seed oil is great.   I'm on escitalopram (SSRI) and find generic adderall to be essential for me.   Some nootropic options are Piracetam, centrophenoxine, bromantane among others to mop up excess acetylcholine. 

I could go on and on, but I think it's important to rule out/rule in whether cholinesterase is at the root of your POIS.   If you suspect adrenal/thyroid (HPA axis) related issues, getting that stuff tested too could be of great value. I'll stop here for now and will update or continue if you have any other questions.  Best wishes to you and our fellow POIS sufferers.     

[demografx]

I just had cataract surgery this morning, maybe now I will see POIS more clearly?