(moved from another thread)
I have news. First of all - my POIS has been minimal since my gut-related efforts (see Mastic Gum, etc). After this success I was perplexed when it resurfaced, although only in a small manner. After considering the idea of hyperammonia I decided to try a few different supplements and eventually I tried l-carnosine. Now something is totally eliminating my premature ejaculation! I think that PE is a common thing that many on this forum share so this might be very significant to others. Also, following O I had zero POIS symptoms. The first time I took one single 250mg capsule. I found that the effect lasts for days and even builds up as time goes on. It has a antidepressant-like effect on me in that I don't feel quite normal on it yet it is not entirely unpleasant. The second time I tried it I took half a capsule (by separating the powder) and it had a similar effect. Again, PE was completely gone and the effect lasted for days. It affects my sleep in that I am able to sleep better but perhaps the sleep is not as deep and refreshing. I have no idea why this might be having this effect, the ammonia idea might be nowhere close to what is happening, but the effect is very profound. I have had severe PE for as long as I can remember! I have never been able to have what I would consider "normal" sex. I am wondering if in my early teens I messed up my development by masturbating too early and intensely, and that carnosine helps restore balance somehow. This is huge for me, I hope others can consider and perhaps benefit from it! It is possible that something else I have tried has made the difference but my best bet is the carnosine.