Author Topic: Could POIS be hyperammonia?  (Read 6871 times)

Muon

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Re: Could POIS be hyperammonia?
« Reply #20 on: October 25, 2023, 08:07:54 AM »
LOLA:
https://en.wikipedia.org/wiki/Hepatic_encephalopathy#L-ornithine_and_L-aspartate

"The combination of L-ornithine and L-aspartate (LOLA) lowers the level of ammonia in a person's blood.[24] Very weak evidence from clinical trials indicates that LOLA treatment may benefit people with hepatic encephalopathy.[24] LOLA lowers ammonia levels by increasing the generation of urea through the urea cycle, a metabolic pathway that removes ammonia by turning it into the neutral substance urea.[25] LOLA may be combined with lactulose and/or rifaximin if these alone are ineffective at controlling symptoms."

Mr Raba

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Re: Could POIS be hyperammonia?
« Reply #21 on: July 11, 2024, 01:12:54 AM »
A recent article

https://www.healthrising.org/blog/2024/06/24/metabolic-changes-chronic-fatigue-syndrome-long-covid/

mentioned LOLA. Hyper ammonia and Oxaloacetate. 

Note that semen contains Aspartic Acid. So if the body replenishes semen (higher priority to reproducirion)  POIS could be the temporary lack of Aspartic Acid, which may lead to less of it to reduce ammonia.

Also note that could explain symptoms becoming worse with exercise.
Simultaneous onset of CFS and POIS since Feb 1993. Married since 1989.

Helped by Immunocal (I explained how to take in previous posts).  Some relief on day one and day two.  It affects neurotransmitters.