I did 20 large-intestine enemas in a row during a period of 2 months (4 enemas each time) and it fixed the constipation issue but had no effects on POIS. I belive POIS has more to do with the small intestine since thats where the vitamins, cholesterol and fat (essential for the hormone balance) are absorbed. You cant reach the small intestines with lavage. The only way is by using a colon cleanse- or SIBOprotocol by mouth.