Warrior's Health Journal & POIS Protocol

[Warrior]

And what is the success of this? (symptoms before-after)

This is all very new. No implementation of the suggestions have occurred yet. Re-ask me in 3-6 months time. I’ve also likely had systemic candida overgrowth for decades at this point. It’s not going to go away overnight. But the test results are what is exciting. Can now isolate and target very specifically.

My current lvl of remission is still as depicted in my videos and main posts. The problem is that I continue to have food sensitivities which degrade the quality of my life, though I have made improvements in developing metabolic flexibility which allows my body to be carnivore/keto for the most part without issues. Carnivore/keto is excellent for food sensitivities but the long term cardiovascular risks I would prefer not to take.

[Warrior]

Claude AIs interpretation of OAT, & suggested supplements. Much of this converges with ChatGPTs interpretation & suggestions. I intentionally took OAT (organic acids test) during peak POIS & food sensitivity symptoms.

Supplement Recommendations Based on Organic Acids Test Results

Primary Concerns

Fungal/Yeast Overgrowth

Multiple elevated fungal markers including citramalic acid (61), 3-oxoglutaric acid (66), furancarbonylglycine (7.9), and tartaric acid (61)
High glycolic acid (87) without proportional oxalic acid elevation suggests fungal metabolism


Mitochondrial Dysfunction

Elevated succinic acid (8.7) indicates respiratory complex 2 dysfunction
Elevated 3-methylglutaric acid (0.73) suggests impaired leucine metabolism


Neurotransmitter Imbalance

Elevated HVA/VMA ratio (1. indicates decreased conversion of dopamine to norepinephrine


Detoxification Issues

Elevated 2-hydroxyhippuric acid (1.1) indicates salicylate exposure or metabolism issues



Recommended Supplement Regimen
1. Anti-Fungal Support

Caprylic Acid: 1000mg twice daily
Justification: Natural medium-chain fatty acid with antifungal properties effective against Candida and Aspergillus species identified in the test results
Berberine: 500mg three times daily
Justification: Botanical compound with broad-spectrum antimicrobial activity, particularly effective against fungal overgrowth
High-Potency Multi-Strain Probiotic: 50+ billion CFU daily
Justification: Helps restore microbial balance to counter fungal overgrowth; specifically mentioned in the test interpretation

2. Mitochondrial Support

Coenzyme Q10: 200mg daily
Justification: Essential for mitochondrial electron transport chain function; directly addresses the elevated succinic acid (respiratory complex 2 marker)
L-Carnitine: 1000mg twice daily
Justification: Supports fatty acid transport into mitochondria; recommended in test interpretation for 3-methylglutaric acid elevation
Riboflavin (B2): 100mg daily
Justification: Cofactor for mitochondrial function; specifically recommended for methylglutaric acid elevation in the test interpretation
Nicotinamide (B3): 500mg daily
Justification: Precursor to NAD+, essential for mitochondrial energy production; specifically recommended in test interpretation

3. Neurotransmitter Support

Vitamin C: 1000mg twice daily
Justification: 1) Patient's level is below mean (12); 2) Required cofactor for dopamine ?-hydroxylase (addresses elevated HVA/VMA ratio)
Copper Glycinate: 2mg daily
Justification: Essential cofactor for dopamine ?-hydroxylase enzyme; addresses elevated HVA/VMA ratio

4. Detoxification Support

N-Acetyl Cysteine (NAC): 600mg twice daily
Justification: Precursor to glutathione; supports detoxification pathways and helps address the 2-hydroxyhippuric acid elevation
Calcium-D-Glucarate: 500mg twice daily
Justification: Supports phase II detoxification and glucuronidation pathways for clearance of toxins

5. Vitamin Optimization

Pyridoxal-5-Phosphate (B6): 50mg daily
Justification: Low pyridoxic acid (0) indicates B6 deficiency; active form is more bioavailable
Pantothenic Acid (B5): 500mg daily
Justification: Level is below optimal (2.2 vs reference mean)
Calcium Citrate: 250mg with meals
Justification: Helps bind oxalates in the GI tract to reduce absorption; beneficial with elevated oxalic acid (88)

6. Additional Support

Magnesium Glycinate: 300mg daily
Justification: Supports over 300 enzymatic reactions including mitochondrial energy production; helps address muscle symptoms from oxalate issues
Vitamin E (mixed tocopherols): 400 IU daily
Justification: Antioxidant support recommended in test interpretation for oxalate issues and mitochondrial dysfunction

Implementation Recommendations

Staged Introduction: Introduce supplements gradually over 2 weeks to monitor tolerance
Priority Sequence:

Begin with antifungal protocol (probiotics first, then gradually add caprylic acid and berberine)
Next add mitochondrial support (CoQ10, L-carnitine)
Follow with vitamin support and detoxification support


Diet Modifications:

Consider low oxalate diet (avoid spinach, soy, nuts, berries)
Eliminate potential exposure to synthetic salicylates (aspartame)
Consider food sensitivity testing due to bacterial markers


Follow-up Testing:

Repeat Organic Acids Test in 3 months to evaluate efficacy
Consider GPL-TOX testing as recommended in interpretation to assess toxic chemical exposure contributing to mitochondrial dysfunction

[SchizoPIOS]

OAT (organic acid test) results are in. I got GPT to interpret, but I am waiting on a consultation with my herbalist. In the mean time, this is what my OAT test is indicating (GPTs interpretation). OAT is commonly used for understanding complex chronic diseases.

1. Fungal/Yeast Overgrowth
Elevated Markers: Citramalic, 5-Hydroxymethyl-2-furoic, Furan-2,5-dicarboxylic, Furancarbonylglycine, Tartaric, Arabinose

Interpretation: Strong signs of fungal overgrowth, particularly from Aspergillus and possibly Candida.

Recommendations:

Antifungal therapy: Either prescription (e.g., Nystatin or Fluconazole) or botanical (e.g., oregano oil, caprylic acid, berberine).

Probiotics: High-quality, multi-strain probiotic (25–50 billion CFU/day).

Dietary adjustments: Avoid sugar, refined carbs, and fermented foods that can fuel yeast.

Consider follow-up testing: Mycotoxin testing for further fungal species insight.

2. Bacterial Overgrowth
Elevated Marker: Hippuric acid

Recommendation:

Digestive support: Probiotics, possibly antimicrobial herbs like garlic, neem, or berberine.

Reduce paraben exposure: Avoid parabens in cosmetics, lotions, processed foods.

3. Elevated Oxalates
Elevated Markers: Oxalic (88), Glycolic (87), Succinic (8.7)

Interpretation: Suggests fungal overgrowth and possibly issues with oxalate metabolism.

Recommendations:

Calcium citrate with meals to bind oxalates.

Vitamin B6 (50–100 mg/day), magnesium, NAC, and taurine to support oxalate processing.

Low-oxalate diet: Avoid spinach, beets, nuts, soy, and chocolate.

Antifungal treatment: Since yeast may be a key source.

4. Mitochondrial Dysfunction
Markers: High 3-Methylglutaric and 3-Methylglutaconic acids

Recommendations:

Mitochondrial support supplements: CoQ10 (100–200 mg/day), Acetyl-L-carnitine (1–2 g/day), Riboflavin (B2), Niacinamide (B3), and Vitamin E.

Investigate possible environmental toxins with a GPL-TOX or heavy metals test.

5. Neurotransmitter Imbalances
Findings: Low VMA, high HVA/VMA ratio, low 5-HIAA

Interpretation: Suggests low norepinephrine/epinephrine, dopamine dominance, and low serotonin.

Recommendations:

Support neurotransmitter synthesis:

Vitamin C (500–1,000 mg/day) and copper for dopamine beta-hydroxylase support.

Tryptophan or 5-HTP for serotonin (monitor carefully).

Avoid aspartame.

Consider genetic SNP testing (MAO, COMT, DBH).

Mood support: Use SAM-e, adaptogens (ashwagandha, rhodiola), or amino acid therapy based on symptoms.

6. Vitamin Deficiencies
Low Markers: B6 (pyridoxic acid), B12 (methylmalonic), B2 (glutaric), Vitamin C, CoQ10

Recommendations:

Start with a broad-spectrum B-complex with activated forms (e.g., P5P for B6, methylcobalamin for B12).

Add Vitamin C (buffered if sensitive).

CoQ10 for mitochondrial and antioxidant support.

7. Toxicity Indicators
Elevated Succinic and 2-Hydroxyhippuric acids

Recommendations:

Reduce or eliminate aspartame and exogenous salicylates.

Consider a detox protocol: sauna, niacin (Hubbard protocol), glutathione or NAC.

Look into environmental toxin testing (e.g., Great Plains GPL-TOX).

This post is incredible, I have never heard of OATs before but your results are incredible.
I have dealt with candida in the past and I most likely still have it, since I have a white coating on my tongue, which is known as oral thrush.
Its incredibly difficult to deal with in my experience, one cheat day and you basically go back to square one. I will write up about my experience when I have more time, I've managed to eliminate some candida from my body for short periods (couple days/couple weeks) in the past and it has huuuuuuge impact on my body, for me the biggest effects was clear eyesight (felt like I was seeing in HD without glasses) and once I had an insanely clear brain, the brain fog completely lifted for a bit and the previous time I got partially rid of it my oral health improved drastically it was like every taste and texture was 10x more intense, that time my oral thrush on my tongue was completely gone for a little while. I never experimented with PMO so cant tell you the effects on POIS.

Also, do you know why the chatGPT is advising to avoid aspartame?
Where did you hear about OATs? It seems geniune although results would vary a lot no? since your urine might get affected a lot by what you previous drank or ate? I did a hair mineral analysis test years ago but now I realised it was probably not very meaninigful, at least it told me I had low levels of toxic metals so that kind of gave me some relief, but the website I heard to get hair analysis tests I now realise was just quackery and the dude is just trying to sell you his supplements

[Warrior]

This post is incredible, I have never heard of OATs before but your results are incredible.
I have dealt with candida in the past and I most likely still have it, since I have a white coating on my tongue, which is known as oral thrush.
Its incredibly difficult to deal with in my experience, one cheat day and you basically go back to square one. I will write up about my experience when I have more time, I've managed to eliminate some candida from my body for short periods (couple days/couple weeks) in the past and it has huuuuuuge impact on my body, for me the biggest effects was clear eyesight (felt like I was seeing in HD without glasses) and once I had an insanely clear brain, the brain fog completely lifted for a bit and the previous time I got partially rid of it my oral health improved drastically it was like every taste and texture was 10x more intense, that time my oral thrush on my tongue was completely gone for a little while. I never experimented with PMO so cant tell you the effects on POIS.

Also, do you know why the chatGPT is advising to avoid aspartame?
Where did you hear about OATs? It seems geniune although results would vary a lot no? since your urine might get affected a lot by what you previous drank or ate? I did a hair mineral analysis test years ago but now I realised it was probably not very meaninigful, at least it told me I had low levels of toxic metals so that kind of gave me some relief, but the website I heard to get hair analysis tests I now realise was just quackery and the dude is just trying to sell you his supplements

This post is incredible, I have never heard of OATs before but your results are incredible.
I have dealt with candida in the past and I most likely still have it, since I have a white coating on my tongue, which is known as oral thrush.
Its incredibly difficult to deal with in my experience, one cheat day and you basically go back to square one.

You need to work with someone who knows what they're doing after treating lots of patients with Candida, fungal, or bacterial overgrowth in the context of complex chronic conditions. I'm working with Byron Herbalist, but he's only available to Australian/New Zealand residents. There's a good chance your condition is Candida fuelled, but you would want to check with an OAT.

Getting concrete evidence is crucial. It might take 3-6 months to clear the fungal overgrowth. 4-5 weeks in you hit a wall, could be a biofilm, resistance, or potency issue, but you may have doubts if you aren't 100% certain you have a fungal problem.

As for the reliability of the OAT, there are instructions you need to adhere to that the provider will disclose through the accompanying forms. This info is also available online. This improves the reliability of the test.

OAT is a great test to screen for Candida, fungal, or bacterial as a cause for POIS. I deliberately triggered food sensitivity and POIS symptoms the day of that I tested. Many of the fungal and Candida overgrowth indicators were through the roof on my test, as you can see from AI's interpretation. I also have a long history of fungal problems, and hit all the anecdotal telltale signs of a fungal overgrowth i.e., food sensitivity to starches, history of eating high sugary chocolate when I was younger, 10 yr toe nail fungal infection that was super treatment resistant, fungal skin infections, responding to monolaurin, depletion of B vitamins, etc. Pretty sure I also got POIS right after a terbinafine prescription that successfuly treated my toe nail. Maybe it moved the fungal into a deeper part of my body causing POIS, who knows.

For now the OAT doesn't prove my POIS is caused by Candida, but it does prove there is an enormous Candida/fungal overgrowth burden on my body at the time I took the test (which was the day I deliberately triggered all possible symptoms, deliberately eating foods I'm very sensitive to, and releasing at least twice).

I also suspect my fungal overgrowth is likely to be accompanied by biofilms. This adds another layer of complexity. In the context of POIS, the fungal overgrowth is likely to be systemic. Not just limited to the GI tract, but other organs. Maybe the prostate for example.

The POIS cluster that responds to methylation may very well be a Candida/fungal overgrowth cause. Candida/fungal overgrowths deplete the body's storage of B vitamins through detox.

Anyway we'll know in 6-12 months time once all of this is given the opportunity to play out. This will be super interesting At the very least, removing this significant burden will improve health dramatically I suspect.

If any aussies or NZers are reading, I'd highly suggest Todd / Byron Herbalist. He doesn't pay me to say this.

[Warrior]

Calcium citrate in theory should help with this cluster of POIS. Fungal/candida overgrowth produces large amounts of oxalates. Calcium citrate helps bind to oxalates passing through the gut.

I also suspect an eye pressure condition that developed about a year ago may be related to oxalates and my high dose D3 use:

Candida Overgrowth (OAT confirmed)

His Organic Acids Test (OAT) showed elevated oxalic acid and arabinose
? This means Candida was overgrowing in his gut and producing oxalates internally

High-Oxalate Load ? Oxalates Circulate in the Body

Oxalates from Candida and possibly past diet started building up in tissues

High-Dose Vitamin D3 + High-Calcium Diet

D3 increases calcium absorption, and he was eating lots of calcium-rich foods (like dairy)

Free calcium + oxalates = calcium-oxalate crystals, which deposit in soft tissues—like the eyes

Oxalates Begin Depositing in the Eyes

This can lead to eye pressure, pain, and inflammation

Especially likely when oxalates + calcium circulate without enough support to clear them

Citric Acid Sensitivity = Sign of Oxalate Dumping

Citric acid made symptoms worse, which often happens when oxalates are being released too quickly
? His body was trying to clear them, but couldn't do it smoothly

High-Dose D3 Worsened Eye Pressure

D3 increases calcium levels, making it easier for oxalates to bind and form crystals

This triggered more eye inflammation and pressure

[Warrior]

Can confirm I am NOT sensitive to vegetables, mushrooms, etc when on a ketogenic diet. When I'm animal-based (and eating large amounts of carbs through fruit, dairy, maple syrup, etc) I get bad symptoms even from these. So something is obviously going on around sugar, fermentation, etc. This all lines up with Candida/fungal overgrowth theory, largely confirmed through recent OAT.

[Aladin]

It would be interesting to have a representative sample of POIS'ers to take the OAT-test and to see wether we all have candida-traces...
It would absolutely make sense that if there's a yeast infection in the prostate....