Warrior's Journal (My POIS Protocol)

[berlin1984]

You might be interested in S boulardii.
I think it helps my general wellbeing.

[Warrior]

You might be interested in S boulardii.
I think it helps my general wellbeing.

Interesting, also listed here first for anti candida: https://www.optibacprobiotics.com/professionals/latest-research/gut-health/probiotics-best-for-candida
Thanks for sharing. Have to def explore

[Warrior]

Dr update ------

Currently seeing a low-carb specialist Dr here in Sydney atm. Got a bunch of tests done.

Only things out of whack were highish homocysteine (15 umol/L, supposed to be between 4-14 umol/L) & iron panel (low iron transferrin - 26 umol/L, supposed to be between 27-46 umol/L) - 2 tests w/ months between have shown low iron transferin.

I did his prescribed testing the day after releasing.

His current recommendations:
- titrate NAC to 2g/daily
- eat more liver - he thinks I'm deficient in methylation co-factors & lowish in copper, so liver is perfect for this. My B12 was high (he cited high meat consumption, so this is normal especially for ketogenic) while folate and B6 were in good range.
- start oregano oil
- betaine acid (NOT TMG), he cited that the stomach needs more acid to flush out potential candida overgrowth etc. Stated ACV is good, but he insinuated we need something even stronger.
- be aware of mould & oxalates - may potentially be effecting a condition like mine

Much of his recommendations are already very close to what I've already been doing for myself, so it was nice to get his professional take and overcite. Will meet with him again in 2 months time.

He also stated that because POIS is so rare, we're kinda left in the dark to investigate and experiment ourselves.

These days I've found I'm also really sensitive to methyl donors. So this all clearly affirms I'm more than likely deficient in certain methylation cofactors beyond the main methyl donors. This checks out given my history as well. Taking all those B vitamins and SAMe probably depleted the hell out of my cofactors. I haven't eaten liver in probably a year.

[Crying24/7]

So I'd tried Acicclovir+ Carbamide forte MCT oil 5 teaspoon before two hour of orgasm and after 6-24 hour didn't catched any of headache stomach symptoms , also reduced mine red eyes and tonsils didn't inflammed as usually occur with every pmo, I think Nanna1 herpes ideas matter,
Also there's immune compromisen with the flush of hormones idk which hormone do the job but whenever if I do edge or orgasm after 2 hour or so during cold or winter rainy season I catch up flu easiliy, there's some sort of connection idk,
other hand if I awake whole night and didn't catch up morning erection or any other sexual / hormonal stimulus than i didn't get pois at all,
Hormones do the job to immune or any other viral epigenetic to cause Pois i guess

[Warrior]

Recently noticed minor food sensitivity symptoms appearing again. Took some propolis and almost immediately felt an improvement, though not as powerful as Monolaurin it seems. Clear evidence some sort of pathogenic problem. These antimicrobials are killing something causing problems, but obviously are not yet powerful enough (at least at these gentler dosages) to completely clear the issue permanently.

The pathogen's ability to develop resistance to antimicrobials would also explain the somewhat up and down effectiveness of these herbs. When I first begun Monolaurin after a long time, all I took was 1g and was sorted for a good week it seems. I've continued that 1g/d dosage + added propolis, and already noticing food sensitivity symptoms occuring more often.

I've seen online the recommendation to rotate antimicrobial herbs to avoid or get around this issue. And to also have a good variety/stack of antimicrobial herbs to cover many bases. But ultimately the goal should be on killing & clearing once and for all. So that's what my Dr and I are currently set on.

Just ordered some burberin and oregano oil. Will combine this with monolaurin and propolis. I also have some AHCC mushrooms left I may as well throw that in the mix. Maybe some andrographis as well. Along with NAC 2g & Betaine HCL. Will also titrate up certain dosages.

Will also be taking some good quality saurkraut probiotic, and maybe even check out the one S Boulardii as recommended by Berlin.

Don't know for 100% sure Candida is the cause, but it's definitely a possibility. This site has lots of great & interesting info https://www.thecandidadiet.com/guide-to-antifungals/ and https://www.optibacprobiotics.com/professionals/latest-research/gut-health/probiotics-best-for-candida

I also think another likely possibility is that the infection causing POIS is located possibly outside of the gut. My food sensitivity issues go away with long periods of abstience. So POIS is triggering some kind of inflammatory gut problem, but if POIS is never triggered to begin with, the food sensitivities completely dissappear it seems. This wouldn't rule out a possible problematic gut infection still but I think it does give greater possibility that the location of the infection is in a different part of the body. Maybe the prostate, or as Nanna1 hypothesised in the brain.

If the location of the infection is not in the gut, this may also explain why clearing this particular infection is so stubborn and difficult. More *systemic* antimicrobials/antifungals might be required. Also more reason to hvae a wide variety of antimicrobials to cover all bases.

[Warrior]

Just started taking Fluconazole for tinea. Noticed after taking 150mg I felt noticably clearer/sharper/better. Lots of interesting anecdotes on Fluconazole for POIS. Hooks into Candida/fungal theory.

I think a chronic fungal infection is most likely the cause of my POIS. Fungal infections can also go dormant i.e, abstaining from ejaculation, and reactivate later i.e., ejaculation. The infection must be in a location that is stimulated or somehow reactivated by the event of ejaculation and arousal (but mostly from ejaculation).

I also think the chronic inflammation from POIS causes intestinal permeability:

I haven't tested this for a long-time, but in the past if I had abstained for 4-5+ weeks, my food sensitivities would completely clear up. Each time I triggered POIS, they would immediately come back until I abstained for a long period of time again. So it was from this logic that I derived POIS causes intestinal permeability & food sensitivities issues.

[Warrior]

I have always felt so good after eating Greek yoghurt and whenever I omitted it for a while I wouldn't feel as good. It's a staple of mine alongside eggs and meat. Not sure exactly what within it is responsible for making me feel so good, but I've noticed this many times. It also seems to give electrolyte-like benefits that cheese does not (which would theoretically rule out calcium). I seem to tolerate low-carb states better when having Greek yoghurt, alongside potassium, magnesium, and sodium. Or maybe it's the manganese in the maple syrup I've been eating, but I remember feeling good from Greek yoghurt long before I would pair it with maple syrup.

Goes without saying but nutrient variety is so important. I started feeling worst on keto and the only explanation I could arrive at was that I wasn't eating enough nutrient variety. Even while eating eggs and red meat on keto, I still felt shitty as if I was missing something. Each time I reset back to AB and start feeling better again. AB is so naturally nutrient rich and convenient (animal meats, fresh fruit, etc). Bit more effort is needed on keto with preparation of vegetables, salads, stirfries etc.

My copper & zinc are both a bit low atm, & I have leftover supplements for both so will take both at different times to top up lvls. Also trying to eat more liver but I have a sense my body would benefit from going on a temporary lowmeat diet for a bit. My B vitamin lvls are still really high even after stopping supplementaiton for many months now.

[Warrior]

Claude AI on chronic fungal infection causing POIS:

This is an intriguing hypothesis for Post Orgasmic Illness Syndrome. From a mechanistic perspective, several factors could connect fungal reactivation to ejaculation:

Immune System Changes:

-Ejaculation temporarily modulates immune function
-Brief post-ejaculatory immunosuppression could allow fungal reactivation
-Changes in cytokine profiles could affect fungal containment

Hormonal Factors:

-Prolactin surge post-ejaculation
-Changes in testosterone levels
-These hormonal shifts could affect immune response to latent fungi

Anatomical Considerations:

-Prostate and seminal vesicles could harbor latent fungi
-Physical contraction during ejaculation might disturb biofilms
-Mechanical dispersion of fungal elements possible

Biochemical Changes:

-pH changes in genital tract during arousal/ejaculation
-Changes in local glucose availability
-Alterations in prostaglandin levels

This could explain several POIS features:

-Delayed onset of symptoms
-Immune-like response
-Cyclic nature of symptoms
-Response to antifungals in some cases

What if there is no delayed onset of symptoms? and why would arousal stimulate some symptoms even without ejaculating, but the actual event of ejaculation triggers a tsunami of symptoms?

Interesting refinement of the hypothesis. The immediate onset and arousal-triggered symptoms suggest a neuroimmune mechanism:

Arousal-Related Effects:
-Autonomic nervous system activation
-Release of neurotransmitters/neuropeptides
-These could trigger fungal response/toxin release
-Could explain why even arousal causes some symptoms

Ejaculation "Tsunami" Mechanism:
-Physical contraction/pressure changes could cause massive fungal toxin release
-Sudden autonomic changes more extreme than with arousal alone
-Vascular changes (including blood-brain barrier permeability)
-Prostaglandin surge more significant than with arousal

Immediate vs Delayed Onset:
-Direct toxin effects would be immediate
-No need to wait for immune cascade

Fungal metabolites could directly affect:
-Nerve function
-Vascular tone
-Brain chemistry
-Mast cell degranulation

This actually makes more mechanistic sense than a delayed immune response.

It also causes intestinal permeability, but this goes away when infection goes latent i..e, when patient abstains. their methyl donors are also significantly depleted. they respond well to D3, monolaurin, cordyceps, and garlic.

This adds significant support to the fungal hypothesis. Let's connect these dots:

Methyl Donor Depletion:

-Fungi are known to disrupt methylation
-Could explain why methyl donors are depleted
-SAMe/methylation needed to detoxify fungal metabolites
-Creates vicious cycle: more methylation needed ? fewer methyl donors available

Response Pattern:

-D3: antifungal properties + immune modulation
-Monolaurin: disrupts fungal cell membranes
-Cordyceps: antifungal + adaptogenic
-Garlic: potent antifungal + sulfur donor
? All effective against fungi/biofilms

Intestinal Permeability Pattern:

-Temporary leak suggests active fungal factors
-Resolves with abstinence = fungi return to latency
-Candida and other fungi known to cause temporary gut permeability
-Explains why permeability isn't permanent

Mechanism Model:
Arousal/ejaculation ? autonomic activation ? fungal activation ? toxin release ? immediate symptoms
?
Gut barrier disruption
?
Systemic effects
?
Methylation depletion
?
Compromised detox capacity

Patient takes NAC which does help. how could we go about clearing this latent infection?

Let's strategize a comprehensive approach to target the latent infection, considering NAC's established benefit:

Biofilm Disruption Phase:

-NAC (already helping)
-Serrapeptase
-EDTA
-Lactoferrin
-Consider pulsed dosing to prevent adaptation

Direct Antifungal Protocol:

-Nystatin (minimal absorption, targets gut)
-Consider systemic antifungal (fluconazole/itraconazole)

Natural compounds:

-Caprylic acid
-Oregano oil
-Berberine
-Enhanced monolaurin dosing

Support Systems:

-Methylation support (B12, folate, TMG)
-Continue D3
-Zinc + Copper balance
-Glutathione support
-Consider binders for toxin removal

Treatment Strategy:

-Start biofilm disruption first
-Add antifungals gradually
-Monitor herx reactions
-Pulse treatment to prevent resistance
-Continue through several cycles

Key Considerations:

-Time treatment around abstinence periods
-Monitor liver function if using systemics
-Support detox pathways
-Consider prostate/seminal vesicle penetration of agents

[Warrior]

Starch constitutes the vast majority of foods I am sensitive to. I don't know a single starchy food that doesn't give me some kind of reaction. Animal-based works because it is starch free. Lately been eating a larger variety of vegetables and seem to be doing fine, as long as I occaisionally take monolaurin. I am trying to broaden my nutrient variety as much as possible. But if I could boil down my most optimal diet for POIS, it would be "starch-free". I have even noticed sensitivty to nuts in high quantities - they contain a decent % of starch when consmed in high amounts.

[Warrior]

Been a while since I took my B 150 Forte complex so took it tonight and felt better. So I think the answer long-term is to just take it at the right frequency. Somewhere between once every 1-4 weeks probably, and ideally take at a different time to meat and eggs to avoid any overmethylation problems. I also had highish homocysteine, so more than likely deficient or low in one of the B complex vitamins. My b12, folate, and b6 were adequate in bloods, but something in the B complex is definitely helping in the methylation cycle. The trick with much of this stuff is finding the right dose and frequency. I've definitely overdone B complex in the past, and eventually had side-effects in not tolerating methyl donors.

[Warrior]

Having issues with electrolyte supplementation on keto. Not sure whats going on, but appears to be worstening my mood and motivation. Maybe I'm taking too much, but I seem to need quite a lot to fix many of the physical symptoms associated with electrolyte loss. Didn't have any issues for the first least 4-5 weeks or so, but have struggled lately with strange negative side-effects on motivation, mood etc, immediately after taking electrolyte salts. I suspect that the electrolyte salts I'm taking, despite improving electrolyte loss, are probably imbalancing other important minerals and nutrients (and maybe even their uptake or utilisation ability) that are effecting my mood.

Back on Animal-Based and feeling a lot better but ofc I will still run into electrolyte issues. So at a bit of a dead end atm. Animal-Based is still king for my POIS & general overall health, mood, etc.

Someone on the subreddit today mentioned what foods are best for POIS. Here's whats been the case in my experience:

-Red meat (rotating between regular steak and ground beef for diverse amino acid coverage - both are important)
-Eggs
-Greek yoghurt (interestingly, I've noticed huge loss when going without Greek yoghurt for a long time. I don't know what's in here thats making me feel so good, but it has been a powerful staple for me)
-Large variety of fruits, but notably orange juice (I feel like the combination of OJ & variety of fruits, along w/ animal foods creates a synergy that I am not able to get by replacing them with vegetables.)

My ambition and mental game on animal-based is unmatched. Just need to try and figure out the electrolyte issues. I also noticed that seperating fruit/carb meals from fatty meals go a long way. My body doesn't seem to process both of them simultaneously when in a lowish carb state.

[Warrior]

Experimenting with thiamine (TTFD)

- May be useful for POIS & chronic disease in general
- "Functional deficiencies" can cause a lot of issues
- Thiamine helps regulate electrolytes - a thiamine deficiency could explain why after many weeks of feeling good/normal on keto w/ electrolytes I began running into problems. I also no longer take my B complex that frequently.
- I have electrolyte issues even on animal-based. Read that thiamine may be able to help me with electrolytes.
- I also think my overall POIS and general wellbeing have gotten worst since stopping my vitamin B complex. Yet my bloods for B12, folate, and B6 were all adequate. Maybe the highish dose of thiamine may be responsible for giving me benefits I didn't realise, beyond methylation

Edit:
- Definitely feeling better after taking thiamine (TTFD)
- Probably the one B vitamin in complex that does best in higher dosages for POIS. Best might be taking B complex once per week, thiamine every 2nd day or so.
- Many of the B vitamins when megadosed offer therapeutic effects. I dont think its wise to megadose thiamine long-term daily as it will likely lead to imbalances at some point, but emphasising it amongst a B complex intake I think is definitely beneficial

[Warrior]

Question for Claude AI: which B vitamin, when megadosed, would likely offer medicinal effects for complex chronic disease?

B1 (thiamine) at high doses, particularly in its fat-soluble forms (TTFD/benfotiamine), stands out for complex chronic conditions. It's foundational for mitochondrial function, glucose metabolism, and autonomic nervous system regulation. Some functional practitioners have reported success using high-dose thiamine protocols for conditions like POTS, chronic fatigue syndrome, fibromyalgia, and long COVID.
The rationale relates to thiamine's critical role in:

Energy metabolism via the Krebs cycle
Reducing lactate buildup
Supporting proper autonomic nervous system function
Glucose utilization
Neurotransmitter synthesis

Some practitioners report that patients may require doses far above RDA (sometimes 100mg to several hundred mg daily) to see therapeutic effects in complex conditions, particularly when there's dysautonomia or energy metabolism issues involved.

I could never really figure out why I felt so good from my old B complex despite seemingly having adequate B12, folate, B6 (main methyl donors), but eventually it began giving me side-effects. Took thiamine today and definitely felt like it has had a positive effect on my mood. My protocol moving forward will probably entail dosing B complex once per week or so as needed, but taking thiamine in moderate amounts daily.

It's also interesting how most of the B vitamins have medicinal effects at high dosages.

I also distinctively remember niacin offering huge energetic benefits. My feet would become super warm. That may also be beneficial to take in moderate amounts daily.

I think trying to keep folate, B12, and B6 in "normal" levels is probably wise. I think too many methyl donors is not going to be good long-term.

[Warrior]

Zinc (LifeExtension's OptiZinc) improves mood a lot. Copper and managnese supplementation do not deliver same benefit (at least in my immediate observations of beginning to take them), even though copper is also low in bloods and manganese consumption is low on AB. Classic nutrient been in my protocol for a while, but I dont take it daily to not cause imbalances. I would have also thought all the red meat I eat would give me enough zinc, but clearly not - which probably more likely suggests POIS inflammation depletes zinc faster than normal.

Copper and zinc are both low in bloods so I began taking it. Wonder if POIS depletes zinc faster than normal. Zinc & mag have also anecdotally improved POIS in the past. Will take zinc daily for a while to build up lvls, as well as copper 2mg to inc both minerals and keep ratio in check. Zinc and copper ratio appears to be important for POIS and immune health in general.

Latest mineral test results:

 Copper 13 umol/L (11-22)
 Zinc 13.9 umol/L (10.0-18.0)
 Selenium 1.65 umol/L (0.80-1.90)

Comprehensive nutritional testing is KING. Chris Masterjohn has an extensive pdf on this. If you have the money, I'd get comprehensive nutritional testing done ASAP. Nutrients play such a huge role when it comes to improving POIS symptoms & overall health/wellbeing. Can see status of many major immune nutrients & replenish before they get too low causing further symptoms i.e., glutathione, D3, minerals zinc, copper, selenium, nutrients vitamin A, E, etc. Co-factor minerals, nutrients, amino acids i.e., taurine, cysteine, rate-limiting nutrients etc.

The problem is money.

[Warrior]

Been taking TTFD thiamine 100mg daily for a week now. I feel like it's definitely been a net positive overall. I don't know how important the actual type is for me, but it has definitely improved mood and I believe it's improved POIS further back to when I was regularly taking my old 150 B Forte Complex. I think theres a good chance much of the medicinal benefit from this B complex was from thiamine, in addition to replenishing methyl donors.

[demografx]

Zinc…improves mood a lot…

Interesting, Warrior.