Warrior's Journal (My POIS Protocol)

[Hopeoneday]

Hi Warrior, it could be that vitamine D regulate adaptive immune
response in regards yours pois and food sensitivites:

Although 1,25(OH)2D3 promotes the innate immune response, it is a suppressor of adaptive immunity [25,26,27]. 1,25(OH)2D3 suppresses immune responses mediated by Type 1 T helper (Th1) cells which are capable of producing inflammatory cytokines.24. sep 2015.

Vitamine D have many many roles in human body.
In my case, 2 doctors and 3 specialists didnt comented my
severe vitamine D defiency from my tests results( it was 9).

[Warrior]

Hi Warrior, it could be that vitamine D regulate adaptive immune
response in regards yours pois and food sensitivites:

Although 1,25(OH)2D3 promotes the innate immune response, it is a suppressor of adaptive immunity [25,26,27]. 1,25(OH)2D3 suppresses immune responses mediated by Type 1 T helper (Th1) cells which are capable of producing inflammatory cytokines.24. sep 2015.

Vitamine D have many many roles in human body.
In my case, 2 doctors and 3 specialists didnt comented my
severe vitamine D defiency from my tests results( it was 9).

The function of D3 is complex, so who knows exactly how it's helping. All I know is that it's been a huge breakthrough for me personally to control D3 serum levels for POIS.

This is absolutely insane that all those specialists failed to comment on your vitamin D deficiency...they should revoke their speciality status... if they aren't picking up on deficiency levels, there is little to no chance doctors are going to comment on low but in-range. The difference between low but in-range and optimal levels can be enormous.

Check out this link here and scroll down to "Vitamin D needed to TREAT Health problems (30 ng to 150 ng)" https://vitamindwiki.com/Is+50+ng+of+vitamin+D+too+high%2C+just+right%2C+or+not+enough#Overview_of_the_controversy

Those with inflammatory conditions appear to do better on serum levels upwards of 50ng/mL. Functional medicine recommends optimal range is between 60-90ng/mL, especially for those with inflammatory conditions. The important thing to keep in mind here is that the optimal serum level of D3 is debated. Not all specialists agree on a specific optimal level. Your doctor may have been trained that 30ng/mL is optimal, while other doctors who are more informed on optimal D3 levels for inflammatory conditions may recommend 80ng/mL or higher for example.

This has been in line with my personal experience with POIS. I am still in the process of identifying my optimal D3 serum level.

Dialling up my D3 has fixed the following POIS and food sensitivity symptoms:
- Fatigued throat which would occur especially after eating non AB foods
- Vastly improved body aches - at one point my body aches were intensifying a lot and couldn't figure out why. Most likely due to D3 levels dropping.
- Fixed weird facial tensions I experience with food sensitivities
- Improvement in mood overall, especially in reducing auditory thought (mental noise)
- Improved intensity of food sensitivity symptoms, but hasn't been able to stop it all together i.e., I still experience mood drops and a very distinct almost flight or fight response activation, even though it has been improved.

[Warrior]

1) SAM-e levels do appear to get depleted from POIS over time, and thus will need to be periodically replenished. No matter how much B complex, choline (eggs), and red meat I eat, SAM-e levels still appear to get depleted, which I think is a significant fact. POIS is clearly depleting SAM-e very directly. I am thus sceptical of alternative ways of replenishing SAM-e (for those with POIS) given that choline, folate, and other B complex vitamins were not able to keep levels maintained like I initially thought. Maybe creatine might work, but it will never be as direct as SAM-e supplementation.

2) SAM-e definitely improves my POIS and food sensitivities, though it does not appear to work as perfectly like it initially did.

3) The medical community don't really know much about SAM-e. It appears to be safe. I think there is a lot more to discover about it though...

[Hopeoneday]

The function of D3 is complex, so who knows exactly how it's helping. All I know is that it's been a huge breakthrough for me personally to control D3 serum levels for POIS.

We knows..
I suspect that pois is neurological and immune disorder.
So if one substance is helping like vitamine D, we can reasarch in wich ways it helping, because vit D i well science reasarched, so we can compare.

[Warrior]

The function of D3 is complex, so who knows exactly how it's helping. All I know is that it's been a huge breakthrough for me personally to control D3 serum levels for POIS.

We knows..
I suspect that pois is neurological and immune disorder.
So if one substance is helping like vitamine D, we can reasarch in wich ways it helping, because vit D i well science reasarched, so we can compare.

It's definitely some kind of immune inflammatory disorder haha thats for sure.

[Warrior]

VAGUS NERVE

Came across this guys post (https://www.reddit.com/r/covidlonghaulers/comments/1bywchc/update_99_recovered_after_treating_myself_for/?share_id=E162hPv3SU3dziZDGn96D&utm_content=1&utm_medium=android_app&utm_name=androidcss&utm_source=share&utm_term=1) from (https://www.reddit.com/r/POIS/comments/1d7x3zb/comment/l76tuft/?context=3) who claims had his POIS cured by fixing his "cranial instability". He had Long Covid as well, and spoke about a documentary where a cranial instability patient was misdiagnosed as MS/CFS for years. Long covid, MS-CFS, and POIS most likely share similar pathology.

I looked into cranial instability, and many of the symptoms are similar to POIS...brainfog, trouble speaking, ringing in the ears, fatigue, etc. I then did some exercises for cranial instability, and do feel like they made me feel better. This was shortly after eating an entire bowel of pasta, so I was expecting some food sensitivity symptoms (I've still come a long way improving those food sensitivitiy symptoms but not enough to reliably eat other foods without symptoms).

Cranial instability then led me to the vagus nerve... many people in the POIS community have spoken about it's possible link in POIS. Currently going down this rabbit hole and finding it very interesting. Links into Nanna1's CNS infection theory as well.

Too early to tell but I thought this was interesting enough to make a post on my thread for future documentation. I am certainly going to explore vagus nerve and cranial instability exercises moving forward just to see if theres anything here!

Interesting reads

https://www.reddit.com/r/POIS/comments/v9hxa4/finally_diagnosed_with_something_concrete/

Excellent video shared by Muon:

Compression of the vagus nerve due to cervical instability in Ehlers-Danlos Syndrome

[Warrior]

Given that there is a really strong chance POIS has something to do with a dysfunctional nervous system, this imo opens the door to many physical practices that may help regulate the overally active nervous system and thus improve symptoms.

Some ideas for these practices include:
Kriya Yoga breathwork, especially Kriya Pranyama
Wim hof
Iyengar yoga
Cranial instability exercises
Vagus nerve exercises
Many more online I am yet to research!
https://www.reddit.com/r/covidlonghaulers/comments/183yvjp/anyone_know_what_the_mechanism_is_behind_the_long/

In the past when I had a Kriya Yoga practice, I distinctively remember one time where I was able to reverse the depletive symptoms (back then they were relatively mild compared to the intensity of my symptoms at their worst 6 years ago) from POIS through my Kriya practice (only for that day). This would obviously need to be repeated for more proof, but it is definitely interesting nonetheless, and peaks my curiosity further for exploring these types of practices to relax the nervous system.

I think this is an entire world worth exploring for those suffering from POIS... to be utilised in conjunction with others nutritional and supplemental therapies. Something I have probably overlooked in my own journey.

In the tantric community and specifically within David Deida's books, he mentions the idea that having non ejaculatory sex increases the prana/life force energy, and thus the person will likely be able to handle more ejaculations. This is basically on the same idea. Distinct physical exercises like Kriya Yoga, or non-ejaculatory sex - where one might work to breathe the energy up and down the spine, will likely have very distinct physiological improvements on nervous system dysfunction aka - it may allow the body to recover from POIS faster and thus handle more ejaculations

I will also mention that Pranyama exercises are also very effective for moving sexual energy away from the groin. This can help those who are abstaining for periods of time.

[Warrior]

So at this point I do not believe high serum D3 and replenished SAM-e are able to completely remedy my food sensitivities, like I thought they possibly would. I still need to get my D3 checked, but I've been taking relatively high dosages for a while. They both improve symptoms significantly, but do not offer complete permanent relief entirely on their own AFAIK. With thta being said, I have not checked the serum levels but moving upwards of 80ng/mL long-term definitely carries risk requiring overview from a medical specialist.

Lately I've been eating quite a bit of pasta, grains, and other non AB foods. Overall, my sensitivities have improved dramatically, but I still experience symptoms. Most mental symptoms are gone, except I do notice my nervous system still gets somewhat rallied up, making me slightly more anxious than usual. Physically I will still experience body aches, but these have improved significantly since upping the D3. The body aches used to be very sharp, occuring all over the body. Now they feel more "broadly" achey, rather than sharp pains. Like my left leg or right arm will be feel achey in general, rather than small localised pins of aches. I also experience headaches and facial tensions. Almost as if someone has hit me across the head with a bat lol. All these symptoms last for 20mins - 1.5hr or so... I've also noticed during that period I can become more lazy and unmotivated than usual.

Contrast to this in the past, I would experinece extreme brainfog and anxiety from eating non AB foods, especially gluten, or even potatoes. This would literally linger into the next day. It would mess up my cognition, social "sense", etc. So improvements have been made! but not 100% there yet to be eating these foods consistently and feeling good, but enough to have the odd break here and there from my AB diet.

[Warrior]

So many similarities between POIS and Long Covid! Lots to be learned from this subreddit that may be able to be applied to POIS!

https://www.reddit.com/r/covidlonghaulers/comments/loe10t/hi_rcovidlonghaulers_im_the_one_who_suffered_a/
https://www.reddit.com/r/covidlonghaulers/comments/183yvjp/anyone_know_what_the_mechanism_is_behind_the_long/

[Warrior]

Bee sting therapy targetted at the location of hypothesised CNS infection:

https://poiscenter.com/forums/index.php?topic=2683.msg23766#msg23766

"So far, it seems like the trigeminal nerve could be the area of the brain most associated with my POIS symptoms."

Resources:
https://www.youtube.com/watch?v=p_Pdbxnc7Wc
https://youtu.be/ccrjJkhdn40?si=Kf1jxKXrBmyYTx8p
"Health and the Honeybee" https://www.amazon.com.au/Health-Honeybee-Charles-Mraz/dp/0964248506
"The therapeutic application of bee products, or apitherapy, is an ancient practice soon to find its place in modern medicine. History reveals that Greek and Roman civilizations benefited from the fruits of th ehive, and that the first Chinese acupuncture needle may have been the sting of a bee. (from back cover)"

[Andre2505]

So at this point I do not believe high serum D3 and replenished SAM-e are able to completely remedy my food sensitivities, like I thought they possibly would. I still need to get my D3 checked, but I've been taking relatively high dosages for a while. They both improve symptoms significantly, but do not offer complete permanent relief entirely on their own AFAIK. With thta being said, I have not checked the serum levels but moving upwards of 80ng/mL long-term definitely carries risk requiring overview from a medical specialist.

Lately I've been eating quite a bit of pasta, grains, and other non AB foods. Overall, my sensitivities have improved dramatically, but I still experience symptoms. Most mental symptoms are gone, except I do notice my nervous system still gets somewhat rallied up, making me slightly more anxious than usual. Physically I will still experience body aches, but these have improved significantly since upping the D3. The body aches used to be very sharp, occuring all over the body. Now they feel more "broadly" achey, rather than sharp pains. Like my left leg or right arm will be feel achey in general, rather than small localised pins of aches. I also experience headaches and facial tensions. Almost as if someone has hit me across the head with a bat lol. All these symptoms last for 20mins - 1.5hr or so... I've also noticed during that period I can become more lazy and unmotivated than usual.

Contrast to this in the past, I would experinece extreme brainfog and anxiety from eating non AB foods, especially gluten, or even potatoes. This would literally linger into the next day. It would mess up my cognition, social "sense", etc. So improvements have been made! but not 100% there yet to be eating these foods consistently and feeling good, but enough to have the odd break here and there from my AB diet.

I also have headaches (in the left back) and tension but in general not necessarily immediately after ejaculation. the third day is the one where I feel most tense of all

[Warrior]

Here’s a post from 3 whole years ago where I was able to significantly still POIS-like symptoms from my Kriya Yoga practice.

https://www.reddit.com/r/kriyayoga/s/UxBE4a5Hdx

At the time I would have been doing long semen retention streaks but was completely unconscious in regards to how much my diet was triggering never ending POIS-like symptoms, which resulted in basically a permanent state of social anxiety, even when abstaining for long periods of time. Whenever I did ejaculate back then, my symptoms were nothing short of extreme. So naturally back then I was trying anything and everything to fix my severe social anxiety and mental symptoms.

The point of this post is to demonstrate to others that Kriya Yoga, especially Kriya Pranayama - arguably the main exercise within Kriya, does appear to somehow improve POIS symptoms rather significantly. The comments in the post actually mention Kriya Yoga inducing the parasympathetic nervous system.

I understand that many around this community are skeptical of “eastern” and “mystical” practices, especially when the word “chakras” can be thrown around quite a bit. I would encourage skeptics to keep an open-mind, and view Kriya Yoga simply as a set of breathing techniques combined with focusing on different parts of the body. The purpose of Kriya is predominately spiritual development, but also to clear physical and emotional blockages within the body to prime it for higher conscious experiences.

[Warrior]

Just tried supplementing Vitamin E & CoQ 10. Noticed quite a significant improvement in energy after the CoQ10. Didn't notice anything after the Vitamin E. My diet is also very low source of vitamin E because I do my best not to eat seed oils. I don't have any strong views on the seed oil vs saturated fat argument apart from the fact that AB diet works very well for me, and I may as well listen to their advice regarding PUFA just in case.

I'm going to start supplementing these from now on provided I don't get any side-effects long-term. Vitamin E is especially important as an anti oxidant for PUFA, recommended by high saturated fat circles. So if theres a way to reduce CVD risk on AB, I'll take it lol. CoQ10 and Vitamin E both seemingly important to improve CVD health.

[Warrior]

Very interesting video on how functional medicine might interpret a CBC. Specifically for me, based on my bloods, I have always had low neutrophils, moderately low white blood cells, and moderately low lymphocites. These values increase back to normal and even go in normal-high range after periods of abstience. Based on this video, it's most like a chronic infection of some sort, likely viral. https://www.youtube.com/watch?v=M-2DA0gL1os

It's not perfect and obviously very complex, but interesting nonetheless, and would further support Nanna1's theory.

[Warrior]

Alright, I'm going to re-attempt Nanna1's immune therapy. Going to do it as intuitively as possible. Here are some notes I made:

My POIS is exceptionally similar to Nanna1’s in terms of symptoms, but also in terms of treatment i.e., methylation, D3, and HHV diagnosis i.e., HHV-6 and VZV, and CBC regarding low WBC and neutrophils See here https://poiscenter.com/forums/index.php?topic=2502.msg47816#msg47816.

This is the perfect depiction of mechanics behind immune therapy (scroll down to last paragraph): https://poiscenter.com/forums/index.php?topic=3151.msg33167#msg33167, basically dial-up AHCC, vitamin C, etc until symptom remission. Do things intuitively, but also keep everything safe.

https://www.youtube.com/@DrJinSung/videos amazing resource on chronic infections, building immunity, biofilm disruptors, etc

Bee venom therapy + apitherapy

Other useful supplements might be GlyNAC, quercetin, monolaurin, propolis, etc. Vitamin C IV.

The process must be intuitive.

[Sisyphus]

Good luck with re-attempting immune therapy Warrior.

Like you, I typically have low WBC and low neutrophils (on average 20% below ref range) but I don't tend to get the fluctations you describe during periods of abstinence. My lymphocyte counts are normal. There certainly seems to be a few poisers with low neutrophils and I wonder how many as a %? My RBC is also on the low side (but only by a small %).

[Warrior]

My gut becomes leaky for about 2 weeks~ following ejaculation if I recall correctly. This would probably put to bed any theory around a latent infection also in the GI tract. The POIS inflammatory storm is cleary making my gut temporarily leaky and thus susceptible to basically all plant foods. I explored this further with Claude AI:

Immune system dysregulation:
POIS is thought to involve an abnormal immune response triggered by ejaculation. This immune dysregulation could temporarily affect the gut-associated lymphoid tissue (GALT), leading to increased intestinal permeability ("leaky gut") and heightened sensitivity to food antigens.

Neuroinflammation:
If there is indeed a latent CNS infection, as you hypothesize, ejaculation might trigger its reactivation or exacerbation. This could lead to neuroinflammation, affecting the gut-brain axis and potentially altering the body's response to food antigens.

Mast cell activation:
POIS symptoms have been associated with mast cell activation in some cases. Mast cells play a role in both allergic responses and neuroinflammation. Their activation during POIS could lead to increased histamine release and food sensitivities.

Cytokine storm:
The immune response triggered by ejaculation in POIS patients might lead to a temporary cytokine storm. This could affect multiple systems, including the digestive system, leading to transient food sensitivities.

Autonomic nervous system dysfunction:
POIS might involve dysregulation of the autonomic nervous system, which could affect gut motility, secretion, and immune function, potentially leading to food sensitivities.

The temporary nature of these food sensitivities (disappearing after 14 days of abstinence) suggests that the underlying mechanism is reversible and directly linked to the POIS state. As the immune system and neuroinflammation settle down, the food sensitivities resolve.
To better understand this connection, you might consider:

Investigating inflammatory markers and cytokine levels during POIS episodes and comparing them to baseline.
Assessing gut permeability and microbiome composition during and outside of POIS episodes.
Evaluating mast cell activation markers during symptomatic periods.
Conducting neuroimaging studies to look for signs of neuroinflammation during POIS.
Testing for specific food antibodies during and outside of POIS episodes to see if there are measurable differences.

[Warrior]

Low-Cholesterol Version of Animal-Based:
Goal is to reduce CVD risk while maintaining AB diet.

• Lean chicken breast – does not feel as good after eating red meat, and certainly not as satiating.
• Eggs
• Sardines
• Salmon
• 5% lean red meat
• Mussels, pawns, seafood mix, etc

• 1 avocado per day
• Olives
• Olive oil
• 1 cup max of full fat yoghurt
• Low-fat dairy

• Sweet potato is the least inflammatory starchy carbohydrate for me. Tested multiple times & they're significantly better than literally ALL other starchy carbohydrates inc. white rice, white potatoes, gluten, etc.
• All fruits including banana, apple, medjool dates, pears, orange juice, etc.
• Vegetables-like fruits including avocado, cucumber, etc.

• Saurkraut
• Kefir

Experiment list:
• 1 cup of nuts i.e., walnuts
• Restricted quantities of plant foods
• 1 carrot
• Etc

[SchizoPIOS]

Hey Warrior,

So I had stopped taking fenugreek a while back when I realised it made me smell of it.

Well I had an O 3 days ago, Idk why but I was way too aroused and the O was very intense, it gave me quite strong POIS symptoms the past few days, more than usual, I think there is a correlation between arousal levels, O intensity levels and POIS level.
I felt really really bad yesterday, my testicles felt really sore and stinging then had the genius idea to take some fenugreek and in literally 10 seconds my testicle pain was gone.

I have a theory that maybe you can voice your opinion about, which is that anaphrodisiacs will dampen arousal levels, O intensity and eventually POIS symptoms. Actually I had read on this forum that fenugreek lowers O intensity. At the same time, I'm not sure about you but I suffer from PE, and I've noticed in the past that beer gave me more control, it happens to be an anaphrodisiac, muscle relaxant and increases mood. SSRIs increase mood, they lower libido and also happen to make people last longer.

I've been wondering if using these kind of anaphrodisiacs (well I don't really want to try SSRIs but the natural ones) might lower arousal, libido, PE and POIS symptoms.
The natural SSRIs also happen to lower libido.

I kinda feel obsessed with sex and my performance issues which are causing extra problems in my life, its been a couple years I've definitely been too obsessed with all sexual stuff, it would be nice to kinda take a break from sexual thoughts and focus on other things in life. My PE also makes me not want to go out and meet new people

[Warrior]

Hey Warrior,

So I had stopped taking fenugreek a while back when I realised it made me smell of it.

Well I had an O 3 days ago, Idk why but I was way too aroused and the O was very intense, it gave me quite strong POIS symptoms the past few days, more than usual, I think there is a correlation between arousal levels, O intensity levels and POIS level.
I felt really really bad yesterday, my testicles felt really sore and stinging then had the genius idea to take some fenugreek and in literally 10 seconds my testicle pain was gone.

I have a theory that maybe you can voice your opinion about, which is that anaphrodisiacs will dampen arousal levels, O intensity and eventually POIS symptoms. Actually I had read on this forum that fenugreek lowers O intensity. At the same time, I'm not sure about you but I suffer from PE, and I've noticed in the past that beer gave me more control, it happens to be an anaphrodisiac, muscle relaxant and increases mood. SSRIs increase mood, they lower libido and also happen to make people last longer.

I've been wondering if using these kind of anaphrodisiacs (well I don't really want to try SSRIs but the natural ones) might lower arousal, libido, PE and POIS symptoms.
The natural SSRIs also happen to lower libido.

I kinda feel obsessed with sex and my performance issues which are causing extra problems in my life, its been a couple years I've definitely been too obsessed with all sexual stuff, it would be nice to kinda take a break from sexual thoughts and focus on other things in life. My PE also makes me not want to go out and meet new people

Yeah man apparently fenugreek makes your odour smell sweet or something. The raw garlic will definitely make you stink unless you limit it to 1/3 of a clove or so. Thats what I did when I used to take them.

There does appear to be a correlation with arousal levels and intensity of POIS symptoms.

Anaphrodisiacs might help POIS by lowering arousal and thus intensity of symptoms. Much of this stuff can vary on a case by case. So you really just need to experiment and find what works for you man.

I've had ejaculations in the past where the arousal was very low, and I did feel like it reduced my symptoms. I think it's the same concept behind why wet dreams don't seem to illicit as intense symptoms. They aren't going to be as arousally intense compared to a sober ejaculation.

Using anaphrodisiacs might help your PE and POIS symptoms. Can't hurt to try bro!

I think theres a big list of anaphrodisiacs and other things you can play around with for reducing libido. Meat and eggs will most likely increase libido. Look into fasting. I know for sure my libido gets absolutely tanked when I'm in a caloric deficit. Thats another huge factor. Your body doesn't want to have sex if you aren't getting enough food or it's too stressed out i.e., you're smashing your body with exercise etc. Those things might not be healthy long-term tho. A vegetarian diet would could work really well unless of course you have food sensitivities like I do...

As for the PE stuff, which is kind of a separate issue and I can't really speak on it because I've fortunately never had those issues but I will give you my advice that I told my buddy who struggles with the same problem:

You really just need to talk about it when it happens. Just embrace it. Don't try and act all cool in the moment playing it off etc. Just vocalise exactly how you're feeling. This is going to require vulnerability and honesty on your part. It might sting your ego a bit, but the pressure of wanting to perform etc and the ego involved in that is exactly what is probably causing the PE. If you're having sex, then you're having a relationship with that person. All relationships require honesty and vulnerability for true connection. Read the book Models by Mark Manson. This is also how you develop true confidence, which is the main concept taught in the book.

If you ejaculate too quickly, who cares? A women is only going to take that as a compliment. If you haven't satiated her yet, you can easily do foreplay and all sorts of juicy things to her after...

Another thing you can look into is kegal exercises. Taylor Johnson who teaches how to do an integrative semen retention lifestyle has videos on this that I would recommend. He also talks quite a bit about the topic of PE because he struggled a lot with it as well.

Totally something you can overcome bro. Even then I personally don't see it as a big deal or anything really to overcome, apart from the fact that you just got turned on so hard because she's so beautiful. Haha as I said I would just embrace it, and be ok being the dude who finished early but gave her the most mindblowing oral sex she's ever had.

Hope that helps. Take whatever helps you, feel free to discard if you don't resonate with it.