Author Topic: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs  (Read 7108 times)

b_jim

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #60 on: November 29, 2024, 07:44:41 AM »
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.
« Last Edit: November 29, 2024, 11:12:33 AM by b_jim »
Taurine = Anti-Pois

demografx

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #61 on: November 29, 2024, 12:30:03 PM »
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.

Fascinating, b_jim! Your research with taurine goes way back to our predecessor-forum beginnings in 2007!
« Last Edit: November 30, 2024, 12:06:35 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Progecitor

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #62 on: December 01, 2024, 12:12:31 PM »
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.

This combination sounds to be a good idea! Coincidentally a treatment scheme for diabetic neuropathy may actually work in the treatment of POIS as well. Besides benfotiamine some of the following could be also utilized. As an available PKC inhibitor lycopene could be used.
I have just begun on a higher dose (100-150 mg) of benfotiamine, but I can certainly see some benefit. Niacin, lycopene, R-ALA and aspirin are also quite useful. ALCAR was less so and unfortunately for some reason I still have trouble with taurine, but this may be specific to my case.

With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril).
https://onlinelibrary.wiley.com/doi/full/10.1155/2013/168039
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.

demografx

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #63 on: December 01, 2024, 04:10:28 PM »

1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.


This combination sounds to be a good idea!…


Please keep the forum informed as to progress!
« Last Edit: December 02, 2024, 10:52:49 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Warrior

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #64 on: December 01, 2024, 04:33:58 PM »
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.


My TTFD has a small amount of magnesium taurinate in it which the brand have done deliberately. I keep hearing about combining it with magnesium and taurine. Must be something to it for sure.
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
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Warrior

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #65 on: December 01, 2024, 06:26:11 PM »
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.

This combination sounds to be a good idea! Coincidentally a treatment scheme for diabetic neuropathy may actually work in the treatment of POIS as well. Besides benfotiamine some of the following could be also utilized. As an available PKC inhibitor lycopene could be used.
I have just begun on a higher dose (100-150 mg) of benfotiamine, but I can certainly see some benefit. Niacin, lycopene, R-ALA and aspirin are also quite useful. ALCAR was less so and unfortunately for some reason I still have trouble with taurine, but this may be specific to my case.

With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril).
https://onlinelibrary.wiley.com/doi/full/10.1155/2013/168039

You might be interested in what r/7e7en87 (https://www.reddit.com/r/POIS/comments/1guili4/comment/lyxhrh4/?context=3) has been sharing at the POIS subreddit. I see overlap with his and your contributions - you might have a similar POIS cluster like I do. His contributions have been huge for my own POIS. He recommends ALA, taurine, TTFD along with magnesium taurate, creatine, methyl donors, cordyceps (high quality brand like Oriveda), D3 and some others. He's constantly updating his stack. I have found him very useful.
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
My POIS Protocol | My YouTube Channel

b_jim

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #66 on: December 02, 2024, 03:08:56 AM »
Thanks.

A 2020 animal study says :

- Thiamine has a critical role in spermatogenesis
- The group taking anti-thiamine drug (metronidazole) shows an important drop  of free testosterone, sperm concentration and moderate drop of LH/FSH.
- Anti-oxydant grapefruit might influences some datas.

The study didnt't prove thiamine deficiency explain the drops but it  maybe attributable to thiamine deficiency and oxidative stress.
.

So I think it's not stupid for poisers to try to boost our B1 level and increase anti-oxydant with food.
« Last Edit: December 02, 2024, 03:16:53 AM by b_jim »
Taurine = Anti-Pois

Sisyphus

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #67 on: December 02, 2024, 06:36:02 AM »
You might be interested in what r/7e7en87 (https://www.reddit.com/r/POIS/comments/1guili4/comment/lyxhrh4/?context=3) has been sharing at the POIS subreddit. I see overlap with his and your contributions - you might have a similar POIS cluster like I do. His contributions have been huge for my own POIS. He recommends ALA, taurine, TTFD along with magnesium taurate, creatine, methyl donors, cordyceps (high quality brand like Oriveda), D3 and some others. He's constantly updating his stack. I have found him very useful.

That's an interesting sub reddit, especially when he writes that his POIS is alleviated by multiple O's.

He gets POIS after one O.
His POIS is alleviated by multiple O's.
His POIS is worse after one O when preceded by a period of abstaining.

experience 3: "If I ejaculate a few more times in succession, my POIS symptoms become less intense, and the burning sensation decreases as well."
Isn't this the opposite of most people's POIS?
I thought most people get worse POIS symptoms the more times that they have O's?.
Do cases like this imply that it is time for the "O" requirement for POIS to be readdressed?!

He theorises about a chronic fungal infection. I suppose that is possible but imo, everything he describes could just as easily be autoimmune or allergy related or 100 other things.
ex/ another speculative theory (autoimmune?): Could it be the mere presence of sperm at a certain point in their life cycle in a particular area of the body (epidymis, vas deferens, urethra etc) that is triggering this person's POIS rather than an O? etc.
« Last Edit: December 02, 2024, 06:55:35 AM by Sisyphus »

demografx

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #68 on: December 02, 2024, 10:56:07 AM »
Thanks.

A 2020 animal study says :

- Thiamine has a critical role in spermatogenesis
- The group taking anti-thiamine drug (metronidazole) shows an important drop  of free testosterone, sperm concentration and moderate drop of LH/FSH.
- Anti-oxydant grapefruit might influences some datas.

The study didnt't prove thiamine deficiency explain the drops but it  maybe attributable to thiamine deficiency and oxidative stress.
.

So I think it's not stupid for poisers to try to boost our B1 level and increase anti-oxydant with food.


Thanks, b_jim!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #69 on: December 02, 2024, 10:58:46 AM »

Do cases like this imply that it is time for the "O" requirement for POIS to be readdressed?!


It’s still “early” enough in POIS research that we can think flexibly!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Warrior

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #70 on: December 03, 2024, 05:27:20 AM »
This guys channel (EONutrition) is a treasure https://www.youtube.com/watch?v=uod2DoGejvI. I know berlin already gave a link to his site in the original post, but his YouTube channel is filled with interesting anecdotal podcast reports of people's experiences with thiamine and medicinal dosing of other nutrients. Many of them have conditions that appear to be very similar to POIS.
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
My POIS Protocol | My YouTube Channel

berlin1984

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #71 on: December 03, 2024, 08:43:06 AM »
Just to chime in, I'm also taking TTFD for quite some time now (several months) and I definitely like it and will keep taking it.
It's good for my general energy and my normally lacking gut motility. (I think it also improves my POIS as my feeling is everything that is anti-fatigue, pro-muscle-building or pro-male-fertility or pro-testosterone is also improving POIS)

I also liked this guest post of the EONutrition guy on another blog (HormonesMatter): https://hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/

b_jim

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #72 on: December 04, 2024, 03:01:16 AM »
Yes I saw this.
It seems there is a vicious circle. Low B1 causes Sibo/bad digestive functions and vice versa.
Taurine = Anti-Pois