General Category > What is POIS
POIS media coverage megathread
Muon:
What is post orgasmic illness syndrome and how do you treat it?
Muon:
August 23 2023: POST-ORGASMIC ILLNESS SYNDROME SUCCESSFULLY TREATED WITH OMALIZUMAB (T J)
Use a youtube downloader to download and watch the video.
NSAIDs, high dose antihistamine therapy and SSRIs were considered ineffective.
Treatment: 3 months of therapy with 300 mg Omalizumab every 4 weeks. Patient had improvement of symptoms 3 days after start of therapy. I will add this to the pois paper treatment thread.
https://en.wikipedia.org/wiki/Omalizumab#Mechanism_of_action
demografx:
--- Quote from: Muon on August 31, 2023, 06:03:47 AM ---August 23 2023: POST-ORGASMIC ILLNESS SYNDROME SUCCESSFULLY TREATED WITH OMALIZUMAB (T J)
…
--- End quote ---
Thank you. Passed along to POIS Research Teams.
Quantum:
--- Quote from: Muon on August 31, 2023, 06:03:47 AM ---August 23 2023: POST-ORGASMIC ILLNESS SYNDROME SUCCESSFULLY TREATED WITH OMALIZUMAB (T J)
Use a youtube downloader to download and watch the video.
NSAIDs, high dose antihistamine therapy and SSRIs were considered ineffective.
Treatment: 3 months of therapy with 300 mg Omalizumab every 4 weeks. Patient had improvement of symptoms 3 days after start of therapy. I will add this to the pois paper treatment thread.
https://en.wikipedia.org/wiki/Omalizumab#Mechanism_of_action
--- End quote ---
Very interesting case report !
Sadly, they do not share how they came to decide to try omalizumab ( Xolair) for POIS. It is an allergic asthma treatment, and also treats urticaria (hives). The patient's symptoms were nausea and a decline of cognitive functions, starting 5 minutes after O, and his blood tests were normal, so I wonder how the immunology department came to this decision.
Xolair works essentially by depleting free IgE antigens. so that basophils, mast cells, and dendritic cells are gradually down-regulated. This case report goes in line with the last article of the late Dr. Waldinger, that POIS is an auto-immune disorder.
Muon:
The reason she tried it is because desensitization works in some cases and antihistamines were ineffective. The high affinity receptors for IgE are downregulated on the cells you mentioned not the cells themselves. Omalizumab is used in MC disorders as mast cell stabilizer when other MC stabilizers fail to be effective. Can we move the discussion to this thread? https://poiscenter.com/forums/index.php?topic=4412.0
Navigation
[0] Message Index
[#] Next page
[*] Previous page
Go to full version