POIS Theory Master List

[Muon]

https://www.reddit.com/r/POIS/comments/1ezk7lg/pois_starting_after_30/

Interested in hearing from guys who have “secondary” POIS that started in your 30s or 40s. What are your theories as to what triggered it? What changed if anything?

I did not have POIS in any shape or form for the majority of my life and then seemingly spontaneously about 7 years ago in my late 30s a switch flipped and nothing was ever the same. I thought I was dying at first lol.

I do have a theory that my lifestyle in my 30s triggered the condition, particularly my enthusiastic use of a certain powdery white substance. I think I caused some sort of brain chemistry imbalance that set off a chain reaction. A few one offs aside, the lifestyle is well behind me, but I have not healed. It would be great if the injury was not permanent, but who knows.

https://www.reddit.com/r/POIS/comments/1ezk7lg/comment/ljl7k0o/

In my case, however, I think it is somehow genetics. My family has a history mental disorders. Depression, anxiety, psychosis etc.

[Muon]

Do we need fMRI studies for POIS, like these?
https://www.mdpi.com/1648-9144/60/8/1370
https://www.mdpi.com/2076-3425/14/5/450

[demografx]

Do we need fMRI studies for POIS, like these?
https://www.mdpi.com/1648-9144/60/8/1370
https://www.mdpi.com/2076-3425/14/5/450

Sure, Muon, got $50,000+++?


The cost of an fMRI study - - NOT including professional administrators, science writers, lab workers, medical analysts, etc. - - can vary significantly depending on the location and institution. At the University of Michigan, the scan rate is $561 per hour, with a recommendation to budget $600 per hour for grant proposals. Yale School of Medicine charges $696 per hour for their Siemens 3T scanners, with a typical 1.5-hour session costing $1,044. Prices can also differ by state, with costs ranging from $274 in Arkansas to $343 in California.

[Muon]

https://www.reddit.com/r/POIS/comments/1gb3usl/sexmasturbating_causing_reactivation/

"Every time I have sex or masturbate, my EBV reactivates. I get exhausted for the next couple days, and get red spots on the roof of my mouth and swollen tonsils with pus on them.

If I have sex and/or masturbate multiple times and get too fatigued, my ulcerative colitis will flare until I abstain from sex or masturbating for at least a few days to a week. Then the colitis and EBV will both go back into remission.

It's also suspected that my ulcerative colitis is actually EBV Colitis that mimicks ulcerative colitis."

[Muon]

Sexual activity poll on CFS reddit:
https://www.reddit.com/r/cfs/comments/1ggmu29/do_you_have_triggers_related_to_sexual_activity/

Same poll on MCAS reddit:
https://www.reddit.com/r/MCAS/comments/1ggl1xq/do_you_have_triggers_related_to_sexual_activity/

[Muon]

https://www.reddit.com/r/POIS/comments/1gmfh78/comment/lwe6ke1/

Personally I believe this is all driven by the parasympathetic nervous system. Most of the people here fit the criteria of acetylcholine dominance. There are a few things you can do, but there is no magic pill. So your sympathetic system is asleep and your stuck in this dark state. The only way out is to lower choline. Choline manufactures acetylcholine, when acetylcholine is high dopamine is low. there is an inverse relationship to the two. Tonic water has quinine which lowers acetylcholine. Search reddit, loads of ideas on this. One way to tell is if your breath rate, is low like 8 breaths per minute. Normal is around 14 breaths per minute . Is your blood pressure low? All of these things show what's going on with the autonomic system.

https://poiscenter.com/forums/index.php?topic=3591.0

[Muon]

An extension of the previous post:

No_Age1208:

EDIT 2: My hormones are all normal, which... fun. So wish that could've been a solution.

Good question from POIS patient:

Pois_sufferer:

So r u female, how do you react to periods ? Curious to know about it, as with all of us slight hormonal flush do mess with immune response that leads latent virus to Reactivation.

No_Age1208:

Definitely have a reaction to my periods, (flushing, joint pain) but not as severe as the kind I get to orgasms.

[Jan]

Hi fellow patients,

Dr. De Boer has retired. He treated several patients with POIS and was also involved in research. He is listed on the "List of Doctors Who Know about POIS and are seeing POIS patients." I visited him as well and was impressed by his personal commitment. I sent him a thank-you message. Since he was involved with multiple POIS patients and research, perhaps more people could send him a message?

dr.lj.deboer at dbmgz.nl

I suspect he would appreciate this.

[demografx]

Hi fellow patients,

Dr. De Boer has retired. He treated several patients with POIS and was also involved in research. He is listed on the "List of Doctors Who Know about POIS and are seeing POIS patients." I visited him as well and was impressed by his personal commitment. I sent him a thank-you message. Since he was involved with multiple POIS patients and research, perhaps more people could send him a message?

dr.lj.deboer at dbmgz.nl

I suspect he would appreciate this.

Thanks, Jan!