POIS Theory Master List

[demografx]

The NP-C explained to me that Cialis IMPROVES NERVE CONDUCTION!

Thanks for putting this in your Theory thread (and thank you for organizing it!)

[Muon]

I've been diagnosed with ME/CFS. I'm stunned as I've always considered myself a pretty fit person! Just feel like huffing and puffing while in POIS!

I was diagnosed after a CT scan for the brain together with Neurospect.

I don't think it would influence my test results but just in case; I had 3 ejaculations in the 2 days before the scan test. Apparently there is no blood circulation in the front of my frontal lobe!

[Muon]

Other ways to observe mast cell activity

"Single cell laser microcapture and qRT-PCR should be used to identify mast cell phenotype variability and mediator synthesis/release in situ." Ref

"Electron microscopy using time lapse photography on bladder biopsies from IC/BPS patients and controls to see if the mast cells in the biopsies of IC/BPS patients are degranulating at a more frequent rate, or releasing inflammatory mediators without degranulating compared to the control group."Ref

[Muon]

Spermine/Spermidine depletion theory for POIS:
https://www.mdpi.com/2073-4409/10/8/1867

https://www.sciencedirect.com/science/article/abs/pii/S0031942206002251

S-Adenosyl-l-methionine (AdoMet or SAM) is a substrate in numerous enzyme-catalyzed reactions. It not only provides methyl groups in many biological methylations, but also acts as the precursor in the biosynthesis of the polyamines spermidine and spermine

[Progecitor]

Spermine/Spermidine depletion theory for POIS:
https://www.mdpi.com/2073-4409/10/8/1867

https://www.sciencedirect.com/science/article/abs/pii/S0031942206002251

S-Adenosyl-l-methionine (AdoMet or SAM) is a substrate in numerous enzyme-catalyzed reactions. It not only provides methyl groups in many biological methylations, but also acts as the precursor in the biosynthesis of the polyamines spermidine and spermine

In this relation it may be worthwhile to supplement ornithine as well:

Spermidine, a polyamine synthesized in vivo from ornithine, has been reported to induce autophagy through epigenetic regulation of autophagy genes.
https://www.frontiersin.org/articles/10.3389/fcell.2022.811701/full

I have to say though that I have already taken a box of spermidine without much benefit. I took only 1 per day, which was below recommendation, however I took it for two months this way, which makes a deficiency situation less likely.

[Muon]

In my case I believe it's a miss communication between brain and body

[Muon]

I received betamethasone injection for dermatitis three days ago and today it cleared my brain fog, fatigue and most surprisingly PE. Also i don't feel pois on this injection like i can cum 3-4 times with no symptoms (not even 1%).

[Muon]

I will put this here. Apparently the brain has a microbiome. https://youtube.com/watch?v=mZPQ0bgqoq8

[Muon]

7. My POIS theories
My sudden bursts of tachycardia, the inability to regulate my body temperature properly, the lack of appetite that has nothing to do with any issue in my digestive system, the feeling of nausea exactly where the vagus nerve is located under the sternum, my inability to apply pressure to that spot without POIS symptoms appearing... it all seems to fit with some kind of malfunction of the nervous system in general and/or the vagus nerve in particular. I first started thinking of the vagus nerve when I tried to train core strenght using the plank position and got sick, because it implies a lot of muscle tension in that point, same as resting my body weight on it when laying down in bed reading a book had made me sick too. Recently I've tried diaphragmatic breathing when I'm sick with POIS and it seems to reduce the symptoms, which would fit in this theory, since it stimulates the vagus nerve.

Also, the feeling of tension in the diaphragm that I always get before a POIS episode starts could suggest the nerves there being affected. It is a symptom that has got worse with time, and sometimes it even happens when I start eating: my diaphragm and core muscles seem to contract when food enters my stomach, but it goes away if I keep eating.

I wanted to share something that has happened to me this week, and that in my opinion confirms my intuition that something is wrong with my vagus nerve and vagal tone in general, especially since my worsening last year with the bleach.

I'm moving house right now, going back for a year to where I was born, before starting my PhD. It has been a complete mess, with people who had promised to help cancelling at the last minute, so me and my mother were left alone with the prospect of moving dozens of very heavy boxes, shelves, tables, all my gym equipment with weights and a treadmill... Considering my exercise intolerance, I was sure I was going to be extremely sick for days after this. I had got sick with a fever before from just trying to do a couple of push-ups!

Well, for the last three days I've been running up and down the stairs with heavy boxes that I could barely lift, and carrying furniture around. Zero symptoms so far, quite the opposite, I actually feel good! After thinking it over and over, the only explanation I can find is this: I've been talking the whole time while I did all these things. And talking stimulates the vagus nerve! I believe my exercise intolerance is due to my vagus nerve not working properly, so that it's unable to control inflammation.

[Muon]

I suspect that in my case brainstem function needs to be measured upon physical exertion and/or (post) sexual arousal/orgasm.

If i had to guess brain stem has some degenerative changes that makes it super vulnerable and then when you pour neuroinflammation on top of it you can get some nasty symptoms. It might be that we are more susceptable and or lived a life of chronic stress that lead to the brain degeneration.

[Muon]

POIS relief by sleep/naps is common knowledge in the community for years. Often overlooked but can be helpful pinpointing the mechanism in research. Nanna1 has posted graphs about sleep #connectthedots

I'm always relieved, however, the very next day. I wake up, and I can tell immediately I'm back to normal. All symptoms gone. This also works if I take a nap the next day after O-ing. Two sleeps after O, I'm always back.

Does anyone else experience this? It's probably also important to note that I'm Vitamin D deficient. I used to take supplements daily with that, and I definitely did see an improvement, but I've just been bad with taking them every day now.

[Muon]

In my opinion, this problem is related to the liver. The thing that globally affects well-being is insulin sensitivity, which can be improved with a diet for diabetics and aerobic exercise.

The second thing that strongly affects the condition is the limitation of fructose in the diet. I can't give exact numbers, I think it's an individual thing.

[Muon]

Found: the dial in the brain that controls the immune system

A body–brain circuit that regulates body inflammatory responses


A population of neurons in the brain stem, the stalk-like structure that connects the bulk of the brain to the spinal cord, acts as the master dial for the immune system.

Further experiments revealed two discrete groups of neurons in the vagus nerve: one that responds to pro-inflammatory immune molecules and another that responds to anti-inflammatory molecules

Desensitization succes in some individuals might just have been communication between semen content and the vagus nerve.

[Muon]

https://www.reddit.com/r/POIS/comments/1cpeaxy/my_journey_to_overcoming_pois_a_personal_research/

Successful Treatment:The link between varicocele and my symptoms led to a varicocelectomy, which has successfully resolved my POIS symptoms for several months now.

Similarities to Varicocele:Upon further evaluation and testing, I was diagnosed with varicocele, which presented an interesting parallel to the actions of doxycycline.

Both involve:

Increased MMP Activity: Varicocele can lead to higher MMP levels, which cause inflammation and tissue damage, similar to the inflammation mitigated by doxycycline.

Oxidative Stress: Varicocele can induce oxidative stress that damages cellular structures, including mitochondria. Doxycycline’s ability to reduce oxidative stress might explain why it temporarily alleviated my POIS symptoms.

Systemic Inflammation: The systemic inflammation caused by varicocele, driven by oxidative stress and elevated MMPs, closely mirrors the systemic effects that doxycycline helps to control.

[Muon]

it's latent Hsv virus bro, I'm positive for hsv1 and ghsv2 ,
even Aciclovir helps in daily brainfog that I get from morning erection, Also monolaurin helps immensely

[Muon]

I get the impression that the nervous system is hypersensitive, weak and easily overloaded.

POIS: A brief explanation:
https://www.reddit.com/r/POIS/comments/1csv0nu/pois_a_brief_explanation/

After some years I discovered that my symptoms were the result of a dysregulated nervous system. To put it simply, the difference between a person that struggles with POIS and a normal person is down to the sensitivity of their nervous system. A sensitive nervous system could be the result of years of self-stimulation, years of stress, years of trauma, or just genetic. The more the nervous system is over-stimulated by these events, the more sensitive your nervous system becomes.

[Muon]

I have seen comments of patients saying they feel like their (nervous) system ran out of juice with regards to POIS, exercise or even sleep deprivation.

[Muon]

People with thermal hypersensitivity might have abnormal nerve conduction velocities for certain types of nerve fibers.

[Muon]

Every human testicle contained microplastics in a new study

[Muon]

Dr. Matt Curley June 3, 2024:

"They keep saying that the "manifestations are elusive" that's a crock! Its a class 6 allergy to a protein found in semen where the body is convinced it's an invading virus. Since the prostate continues to produce this protein and it's an ongoing war with the immune system."

https://www.cureus.com/articles/245945-post-orgasmic-illness-syndrome-a-case-report#!/

Dr. Curley:

The REALITY is - Niacinamide may potentially worsen the condition. While I realize that a large number of men may try this method, I would warn them to be wary as Niacin related products can actually increase histamine.

Muon:

I have seen someone who developed POIS after high dose Niacin. There is a group of patients which time the niacin flush with orgasm for relief. PGD2 and 5-HT release (platelets) are involved in niacin flush. Low 5-HT is believed by some to be involved due to premature ejaculation

Dr. Curley:

I've been aware of the "Niacin" effect since 04. It has to do with four prostaglandins being released as a result of langerhans cells being triggered (fooled) into thinking that there is an infection present. As a result, the EJ immune system trigger is blunted.