POIS Theory Master List

[Muon]

Men versus women on sexual brain function: Prominent differences during tactile genital stimulation, but not during orgasm

"The only prominent gender difference during orgasm was male-biased activation of the periaqueductal gray matter."

Periaqueductal Gray

The neurobiology of central sensitization

We have similarly shown that decreased connectivity to antinociceptive brain regions, such as the periaqueductal gray (PAG - a critical locus of descending analgesic pathways), predicts responsiveness to milnacipran, a serotonin norepinephrine reuptake inhibitor. https://poiscenter.com/forums/index.php?topic=3312.0

Perhaps the most consistent finding noted to date is a mild elevation in IL-8, which is a cytokine associated with sympathetic function

I wonder if these milnacipran responders have mild elevations of this cytokine.

[Muon]

https://en.wikipedia.org/wiki/Norepinephrine
"Brain areas containing noradrenergic neurons"

[Muon]

Table 2: Potential biomarkers for the AIT efficacy, stratification and efficacy prediction.
Table 3: Biologicals used to support AIT.
Hot topics in allergen immunotherapy, 2023: Current status and future perspective