General Category > POIS Research
POIS Theory Master List
Muon:
--- Quote from: Iwillbeatthis on April 07, 2022, 05:49:55 AM ---Also in most cases I don't think the cause of POIS is mast cell related, its mainly neurotransmitter dysfunctions: imbalanced Glutamate/Gaba ratio causing excitotoxicity, low dopamine, low DBH activity, low BH4, high epinephrine, low norepinephrine, any mast cell symptoms are secondary to the neurotransmitter issues. Correcting gut microbiome imabalances/gut infections, mineral imbalances, methylation impairments, removing heavy metals you will see the neurotransmitter issues correct themselves.
Improving dopamine synthesis, normalising DBH, correcting an imbalanced gaba glutmate ratio will all also help.
This Post from an ME/CFS researcher has a lot of useful information.
https://bornfree.life/experimental-treatment-methodology/7/blood-ph-ion-channel-disturbances-neurotransmitters-and-mineral-deficiencies/37/
A preferred approach (after confirming noradrenaline is low and/or vanillylmandelic acid is low on urine tests), is to normalise DBH, thereby correcting the downstream cascade. This would be best mediated by removing any/all "low-hanging fruit", such as:
1. Quantifying and remediating deficiencies of vitamin C, copper, manganese, magnesium, zinc, lithium, riboflavin and potassium. (PQQ may also be helpful.)
2. Quantifying and remediating interstitial and blood pH. Confirming by blood smear that red blood cell morphology is normal. Any clumping or rouleaux may act to limit other interventions.
3. Quantifying and remediating pulmonary respiration function.
4. Antagonising a2-adrenergic receptors, using a suitable intervention. (At this time, appropriate a2-antagonists may include small doses of yohimbe / yohimbine, rauwolscine and phenoxybenzamine. This is a WIP)
5. Further reducing NLRP-3 using eg. hesperidin.
6. Removing / remediating any detected pathogens that impair DBH - this can be a long process.
7. Investigating a BH4 deficiency - this is difficult to measure directly. This may appear as low levels of neurotransmitters, low ferritin, low intracellular riboflavin, low 5-MTHF / folinic acid, low citrulline.
--- End quote ---
Muon:
Silodosin could be used for research to make a distinction between subgroups by blocking ejaculation.
Muon:
--- Quote from: demografx on June 13, 2022, 09:18:35 AM ---
--- Quote from: Muon on June 13, 2022, 06:11:49 AM ---Silodosin could be used for research to make a distinction between subgroups by blocking ejaculation.
--- End quote ---
Good idea. And Rapaflo?
--- End quote ---
Anything that fully blocks ejaculation. You could end up with 4 groups if the block is successfull:
1) POIS free
2) Diminished symptoms
3) Increased symptoms
4) No effect in symptoms
Group 1 and 4 could be isolated and investigated further.
Muon:
Type IV of hypersensitivity and its subtypes
Classification of hypersensitivity reactions
"It should be noted that some disorders are caused by IgE-independent, nonspecific activation of mast cells, which could be considered to be a subset of type I hypersensitivity reactions."
Perspective of Delayed Hypersensitivity: A review
"There is an increase in leukocyte concentration in tissues where immunological and inflammatory responses are occurring in response to external antigens because of the upregulation of endothelial cell adhesion molecule expression."
Why haven't these Type IV subtypes been explored already? The mediators are shown for each subtype.
dylanmurphy:
Pulsatilla 200c works well so far for me for stopping Ne's (touch wood) !!
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