Author Topic: Tyrosine kinase inhibitors related to pois  (Read 262 times)

Hopeoneday

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Tyrosine kinase inhibitors related to pois
« on: January 24, 2022, 04:18:48 PM »

As i think that somethig toxic-eg infection disbturb ours
signaling pathways in the body:

Reve case:
https://poiscenter.com/forums/index.php?topic=4048.msg43068#msg43068

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698043/

Protein kinases, as key regulators of most cellular pathways, are frequently associated with diseases, either as triggers or as therapeutic intervention points.

The protein kinase family offers a challenge but also an enormous opportunity for drug discovery. Disease arises when signal transduction in a cell breaks down, thereby removing the tight control that typically exists over cellular functions. Devastating diseases, such as cancer, neurological disorders, inflammation, autoimmune diseases, psoriasis, allergic reactions, and hormone-related diseases, can result from abnormal signal transduction.
« Last Edit: January 24, 2022, 04:27:22 PM by Hopeoneday »
Dr-pois.


Muon

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Re: Tyrosine kinase inhibitors related to pois
« Reply #2 on: April 19, 2022, 11:32:19 AM »
https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor#Signaling_cascade

https://en.wikipedia.org/wiki/Protein_kinase_C#Function

Alpha1AR-->PKC

2nd link about PKC shows a couple of 5HT receptors that have been discussed playing a role in premature ejaculation, 2A and 2C.
Also: "endothelial injury and tissue damage related to cigarette smoke". Nas gets POIS symptoms from cigarette smoke.

Hmm it seems it can activate the PI3K/AKT pathway if I'm not mistaken, that one is actually leading to mTOR which is a mast cell activator as well. "Low-level PKC activation is sufficient to reverse cell chirality through phosphatidylinositol 3-kinase/AKT signaling and alters junctional protein organization between cells with opposite chirality, leading to an unexpected substantial change in endothelial permeability, which often leads to inflammation and disease."
« Last Edit: April 19, 2022, 12:16:34 PM by Muon »