General Category > POIS Research

Genetic profile results

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Prospero:
Hi,

As some people shared parts of their genetic profile regarding methylation and detox, Muon asked me to gather them in a single thread - so here it is.

Please notice that these are really incomplete results and a very little part of our genes. Moreover, many of the gene polymorphisms highlighted here are very common. I guess that interpreting these results in terms of their concrete consequences on health is not an easy task for any of us. It would also certainly be interesting to look to the genes for other issues than methylation and detox.

Methylation results :
COMT V158M rs4680 : 2 +/+ (Prospero, Muon's brother), 5 +/- (CuriousCharacter, Berlin1984, drop247, Iwillbeatthis, rollercoaster), 1 -/- (Kurtosis)
COMT H62H   rs4633 : (always the same as the previous one)
COMT P199P   rs769224 : 4 -/- (Kurtosis, Berlin1884, Iwillbeatthis, rollercoaster)

VDR Bsm   rs1544410 : 2 +/+ (CuriousCharacter, rollercoaster), 1 +/- (Kurtosis), 4 -/- (Prospero, Iwillbeatthis, Berlin1984, drop247)
VDR Taq   rs731236 : 4 +/+ (Prospero, Iwillbeatthis, Berlin1984, drop247), 1 +/- (Kurtosis), 2 -/- (CuriousCharacter, rollercoaster)

MAO A R297R   rs6323 : 2 + (Kurtosis, Iwillbeatthis), 1 - (Berlin1984)

ACAT1-02   rs3741049 : 1 +/- (Iwillbeatthis), 2 -/- (Kurtosis, Berlin1984)

MTHFR C677T   rs1801133 : 3 +/- (Kurtosis, Prospero, drop247), 5 -/- (swell, Berlin1984, Iwillbeatthis, CuriousCharacter, rollercoaster)
MTHFR 03 P39P   rs2066470 : 1 +/- (Iwillbeatthis), 2 -/- (Kurtosis, Berlin1984)
MTHFR A1298C   rs1801131 : 1 +/+ (Iwillbeatthis), 5 +/- (Kurtosis, Prospero, Berlin1984, swell, CuriousCharacter), 2 -/- (drop247, rollercoaster)

MTR A2756G   rs1805087 : 1 +/- (Prospero), 5 -/- (Kurtosis, Berlin1984, Iwillbeatthis, drop247, rollercoaster)

MTRR A66G   rs1801394 : 3 +/+ (Prospero, swell, rollercoaster), 5 +/- (Kurtosis, CuriousCharacter, Berlin1984, drop247, Iwillbeatthis)
MTRR H595Y   rs10380 : 1 +/- (Kurtosis), 1 -/- (Iwillbeatthis)
MTRR K350A   rs162036 : 2 +/- (Kurtosis, Berlin1984), 3 -/- (drop247, Iwillbeatthis, rollercoaster)
MTRR R415T   rs2287780 : 5 -/- (Kurtosis, Iwillbeatthis, drop247, Prospero, rollercoaster)
MTRR A664A   rs1802059 : 2 +/- (Kurtosis, Iwillbeatthis), 1 -/- (Berlin1984)

BHMT-02   rs567754 : 1 +/+ (Berlin1984), 1 +/- (Prospero), 4 -/- (Kurtosis, Iwillbeatthis, drop247, rollercoaster)
BHMT-04   rs617219 : 2 -/- (Kurtosis, Iwillbeatthis)
BHMT-08   rs651852 : 1 +/+ (Berlin1984), 1 +/- (Kurtosis)

AHCY-01   rs819147 : 1 +/- (Kurtosis), 1 -/- (Berlin1984)
AHCY-02   rs819134 : 1 +/- (Kurtosis)
AHCY-19   rs819171 : 1 +/- (Kurtosis), 1 -/- (Berlin1984)

CBS C699T   rs234706 : 4 +/- (Kurtosis, Prospero, Iwillbeatthis, rollercoaster), 2 -/- (Berlin1984, drop247)
CBS A360A   rs1801181 : 2 +/- (Kurtosis, Berlin1984), 1 -/- (Iwillbeatthis)
CBS N212N   rs2298758 : 2 -/- (Kurtosis, Iwillbeatthis)

SHMT1 C1420T   rs1979277 : 1 +/+ (Prospero), 1 +/- (Kurtosis), 2 -/- (drop247, rollercoaster)


Detox results :
CYP1A1*2C A4889G   rs1048943 : 2 -/- (Berlin1984, Iwillbeatthis)
CYP1A1 m3 T3205C   rs4986883 : 2 -/- (Berlin1984, Iwillbeatthis)
CYP1A1 C2453A   rs1799814 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
CYP1A2 164A>C   rs762551 : 3 +/- (Berlin1984, Iwillbeatthis, rollercoaster), 1 -/- (Prospero)
CYP1B1 L432V   rs1056836 : 3 +/+ (Prospero, Iwillbeatthis, rollercoaster), 1 +/- (Berlin1984)
CYP1B1 N453S   rs1800440 : 2 -/- (Berlin1984, Iwillbeatthis)
CYP1B1 R48G   rs10012 : 1 +/- (Berlin1984)

CYP2A6*2 1799T>A rs1801272 : 1 +/- (Iwillbeatthis), 1 -/- (Berlin1984)
CYP2A6*20 rs568811809 : 2 -/- (Berlin1984, Iwillbeatthis)
CYP2C9*2 C430T   rs1799853 : 1 +/- (Iwillbeatthis), 3 -/- (Prospero, Berlin1984, rollercoaster)
CYP2C9*3 A1075C   rs1057910 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
CYP2C19*17   rs12248560 : 1 +/- (Iwillbeatthis), 3 -/- (Prospero, Berlin1984, rollercoaster)
CYP2D6 S486T rs1135840 : 2 +/+ (Berlin1984, Iwillbeatthis)
CYP2D6 100C>T rs1065852 : 1 +/- (Berlin1984)
CYP2D6 2850C>T rs16947 : 1 +/- (Berlin1984)

CYP2E1*1B 9896C>G   rs2070676 : 1 +/- (Prospero), 3 -/- (Berlin1984, Iwillbeatthis, rollercoaster)
CYP2E1*1B 10023G>A rs55897648 : 2 -/- (Berlin1984, Iwillbeatthis)
CYP2E1*4 4768G>A   rs6413419 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)

CYP3A4*1B   rs2740574 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
CYP3A4*2 S222P   rs55785340 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
CYP3A4*3 M445T   rs4986910 : 3 -/- (Prospero, Berlin1984, rollercoaster)
CYP3A4*16 T185S   rs12721627 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)

GSTP1 I105V   rs1695   : 1 +/+ (Iwillbeatthis), 1 +/- (rollercoaster), 2 -/- (Prospero, Berlin1984)
GSTP1 A114V   rs1138272 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)

SOD2 A16V   rs4880   : 2 +/+ (Prospero, Iwillbeatthis), 1 +/- (rollercoaster), 1 -/- (Berlin1984)

NAT1 R187Q   rs4986782 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
NAT1 R64W   rs1805158 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)

NAT2 I114T   rs1801280 : 2 +/+ (Iwillbeatthis,rollercoaster), 1 +/- (Berlin1984), 1 -/- (Prospero)
NAT2 R197Q   rs1799930 : 1 +/- (Prospero), 3 -/- (Berlin1984, Iwillbeatthis, rollercoaster)
NAT2 G286E   rs1799931 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
NAT2 R64Q   rs1801279 : 4 -/- (Prospero, Berlin1984, Iwillbeatthis, rollercoaster)
NAT2 K268R   rs1208 : 3 +/+ (Berlin1984, Iwillbeatthis, rollercoaster), 1 -/- (Prospero)




Links to the personal profiles : Kurtosis (M), Berlin1984 (M, D), Drop247 (M), Iwillbeatthis (M, D), Prospero (M, D), swell (M), CuriousCharacter (M), rollercoaster (M, D), Muon's brother.
Iwillbeatthis' more complete profile.
Additional genetic information from Trusttheprocess: FOXP3, IL-12B, CD40 etc

Prospero:
Reserved, for any practical purpose.

Prospero:
Reserved 2.

berlin1984:
Thanks a lot for going through the effort!

What I find very interesting (we also had a poll about this here in the forum) that a lot of people in the forum are engineer/science/nerd type of guys. (No idea about the low number of female POISers we have, but would beinteresting too).

Could be a coincidence that people like us are more likely to visit this kind of forum, but could also be a genetic clue for something.

Muon:
Thanks for the thread!

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