Dumping some half baked info here, will maybe take a look at it later. Could a subgroup of POISers be categorized as certain responders based on this diagram?
https://forums.phoenixrising.me/threads/dr-jay-goldsteins-rapid-remission-me-cfs-treatments.34516/page-6#post-582561Lot of stuff in the diagram is used by POISers.
I was looking at Goldstein diagram earlier. And it seems that Nicotine (dopamine agonist) gives me a bad reaction And Coffee (an Adenosine receptor stimulant) slightly improves my symptoms. So I don't know what's xxxxxx up, my dopamine receptors or Benzodiazepine receptors.
I think you meant to say that it increases adenosine, It's an antagonizer:
Caffeine and adenosine.
https://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_cafeine.html#drogues. Is a weak non-selective PDE inhibitor. Also got acetylcholinesterase inhibition properties.
Mestinon had no effect on Nas. Cigarette smoke induced symptoms in him (discussed this is endothelial dysfuncton thread).
"Nicotine and cigarette smoke both induce the expression of liver enzymes (e.g., certain cytochrome P450 proteins) which metabolize drugs, leading to the potential for alterations in drug metabolism"
https://en.wikipedia.org/wiki/Nicotine#Drug_interactionsI'm not interested to dive into this p450 rabbit hole:
https://en.wikipedia.org/wiki/Cytochrome_P450#Other_specific_CYP_functionsBut it could mess up hormone metabolism, already discussed in the case of Heather in the women's thread. And fatty acids and eicosanoids metabolism which is involved in PLA2/AA cascade inflammation.
Coffee dose dependent is benificial to HOD as benzodiazepines.
Takedrugstoletgo had succes with dextroamphetamine.
Benzo's and nootropics had some effect on my brother's symptoms.
Heather and demo felt awful on progesterone/norethisterone but good on testosterone (they aren't ketamine responders, rather the opposite, and/or dopamine responders).
A few individuals used viagra and PDE4.
Some do improve on mestinon (pyridostigmine)
So far the pyridostigmine (mestinon) isn't doing anything yet in my case. Mestinon increases acetylcholine availability. I feel bad on alcohol, a NMDA receptor blocker, it also blocks or activates nAChRs depending on subtype I believe.
Aren't the selective alpha1 blockers used in Reisman's paper also PDE5 inhibitors? These folks may feel worse on naphazoline. There are PDE inhibitors in the diagram.
I've also read that Midodrine is used for peripheral denervation in dysautonomia.
Me and Ironfeather could be trembling after exercise, isn't this effect also seen in alcohol abusers?