Author Topic: Allergy hypothesis for people with mainly cognitive problems  (Read 247 times)

Drew1312

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Allergy hypothesis for people with mainly cognitive problems
« on: September 18, 2020, 03:21:09 AM »
Can anyone post here  the papers  where they found evidence of allergy?

berlin1984

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #1 on: September 18, 2020, 03:26:20 AM »
I thought it was ruled our by most people many years ago that it's an allergy to anything.
Please vote on: https://poiscenter.com/forums/index.php?topic=3386.0
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Aladin

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #2 on: September 18, 2020, 05:51:45 AM »
As antihistamines help reduce the symptoms for a lot of people here, i don't thin it can be ruled out yet.

Muon

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #3 on: September 18, 2020, 08:27:53 AM »
Can anyone post here  the papers  where they found evidence of allergy?

All POIS papers can be found here: https://poiscenter.com/forums/index.php?topic=3127.0

berlin1984

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #4 on: September 18, 2020, 02:10:06 PM »
As antihistamines help reduce the symptoms for a lot of people here, i don't thin it can be ruled out yet.

Histamine has a ton of functions: https://en.wikipedia.org/wiki/Histamine#Roles_in_the_body
(Says Wikipedia, not me, I'm not a biologist either :-) ).

Might even be that certain antihistamines that people here take have a second function in the body as something else that makes them effective in POIS.
(They're not effective for me though)
Please vote on: https://poiscenter.com/forums/index.php?topic=3386.0
(There's real science behind it, not Astrology..)

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nanna1

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #5 on: September 22, 2020, 10:57:38 PM »
As antihistamines help reduce the symptoms for a lot of people here, i don't thin it can be ruled out yet.
Hi Aladin, Allergy has been ruled out by several POIS papers. For example:
Since Dr. Waldinger first proposed allergy type I and antigen type IV hypersensitivity as a cause of POIS (Waldinger, et al, 2011), several POIS case studies have tested hypersensitivity/allergy responses in POIS patients. It was concluded through semen injection studies that POIS patients do not show a greater allergic response to semen than non-POIS controls (Jiang, et al, 2015). Many POISers do not experience allergic reaction to semen injection. So there is no need to isolate a specific cell type or time frame. Several POIS case studies have ruled out allergy and autoimmunity through autonomous semen injections (Attia, et al, 2013)(Jiang, et al, 2015)(N. Depreux, et al, 2018)(De Amicis, et al, 2019)(Pierce, et al, 2019). So hypersensitivity does not appear to be involve in POIS.

  Centrizine and diphenhydramine failed to treat POIS in this study "Postorgasmic illness syndrome: potential new treatment options for a rare disorder (2019)". The same study showed that after 12 months, desensitization with autologous semen injections did not produce last results.

  The label "anti-histamine" is a marketing term used to maximize profits for drug companies. Most "anti-histamines" are actually broad spectrum receptor inhibitors that block dopamine, serotonin, acetylcholine, histamine and adrenergic receptors. People on this forum who see an effect from cetirizine, hydroxyzine or diphenhydramine (Benadryl) are usually overdosing on these drugs (higher than normal doses). That probably means that those POISers are using the sedative side-effects of the drugs to reduce POIS symptoms. This is called off-label use.
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Drew1312

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #6 on: September 23, 2020, 01:32:32 AM »
As antihistamines help reduce the symptoms for a lot of people here, i don't thin it can be ruled out yet.
Hi Aladin, Allergy has been ruled out by several POIS papers. For example:
Since Dr. Waldinger first proposed allergy type I and antigen type IV hypersensitivity as a cause of POIS (Waldinger, et al, 2011), several POIS case studies have tested hypersensitivity/allergy responses in POIS patients. It was concluded through semen injection studies that POIS patients do not show a greater allergic response to semen than non-POIS controls (Jiang, et al, 2015). Many POISers do not experience allergic reaction to semen injection. So there is no need to isolate a specific cell type or time frame. Several POIS case studies have ruled out allergy and autoimmunity through autonomous semen injections (Attia, et al, 2013)(Jiang, et al, 2015)(N. Depreux, et al, 2018)(De Amicis, et al, 2019)(Pierce, et al, 2019). So hypersensitivity does not appear to be involve in POIS.

  Centrizine and diphenhydramine failed to treat POIS in this study "Postorgasmic illness syndrome: potential new treatment options for a rare disorder (2019)". The same study showed that after 12 months, desensitization with autologous semen injections did not produce last results.

  The label "anti-histamine" is a marketing term used to maximize profits for drug companies. Most "anti-histamines" are actually broad spectrum receptor inhibitors that block dopamine, serotonin, acetylcholine, histamine and adrenergic receptors. People on this forum who see an effect from cetirizine, hydroxyzine or diphenhydramine (Benadryl) are usually overdosing on these drugs (higher than normal doses). That probably means that those POISers are using the sedative side-effects of the drugs to reduce POIS symptoms. This is called off-label use.



Can you please look here?


https://www.researchgate.net/publication/333610277_The_Post_Orgasmic_Illness_Syndrome_POIS_Selective_Bibliography


Elevated  seminal specific IgE


I personally think there may be difference causes. What 's your opinion on this?

nanna1

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #7 on: September 25, 2020, 12:15:22 AM »
Can you please look here?

https://www.researchgate.net/publication/333610277_The_Post_Orgasmic_Illness_Syndrome_POIS_Selective_Bibliography

Elevated  seminal specific IgE

I personally think there may be difference causes. What 's your opinion on this?
Hi Drew1312,

  Thanks for your question. The paper that you reference (Stafie and Stafie, 2019) is very similar to Waldinger, et al. (2011) and Kim, et al. (2018)(Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome). The papers Waldinger (2011), Kim (2018) and Stafie (2019) all found elevated IgE in semen and produced positive skin prick test. But none of them was able to find an antigen associated with IgE, and they also did not have a healthy control group to compare their results to. They did not establish a cause and effect relationship between semen allergy and POIS.

  Then Attia, et al. (2013) published the paper Post-orgasmic illness syndrome: a case report (version 1; peer review: 3 approved with reservations, 1 not approved) which was reviewed by several famous POIS researchers, including 3.Goldmeier and 4.Waldinger. Attia correctly argues that it is not possible for POIS to be caused by an allergy because the immune system would attack any part of reproductive system producing protein antigen (like sperm). Below is a direct quote from Attia's response to Waldinger's review of the paper:

"In regards to testing for allergic reactions, we would like to ask whether you think that the skin prick test is reliable as a diagnostic test for allergy. Is it valid to conclude that POIS patients are allergic to their own semen on the basis of this test and suggest that this is the cause of POIS? We would suggest that skin prick tests can lead to many false positive and negative results. As andrologists we know (and there is a body of evidence for this), that semen is regarded as foreign by the body and the immune system. Immune tolerance to semen is not present. Semen is separated from the immune system by a very competent blood-testis barrier that is formed by the highly efficient Sertoli-Sertoli cell junctional complex. We would suggest that this is not a "hypothetical membrane". In certain known pathological conditions this barrier may be broken. If this occurs, auto-antibodies can form against semen. Thus, if a subject's own semen is then injected intradermally, a reaction may take place as it is recognized as a foreign antigen. We would suggest that many people would get a positive reaction on the basis of such a prick test even though they do not suffer from POIS. If allergy to the patient's own semen is a suspected cause of POIS, it will be necessary to measure serum and seminal plasma anti-sperm antibodies; IgA, IgG and IgM, to conduct immuno bead and MAR testing and to report on the patient's seminogram changes. This might also suggest that POIS patients would be mostly infertile due to formation of anti sperm antibodies.

  Given these concerns regarding prick testing, we do not believe that the cause of POIS is allergy to one's own semen and also have doubts about the use of hyposensitization as a possible treatment."

 -Post-orgasmic illness syndrome: a case report (Attia, et al., 2013) (reply to reviewer 4)

  After the Attia (2013) paper, Jiang, et. al. (2015) published "Postorgasmic illness syndrome (POIS) in a Chinese man: no proof for IgE-mediated allergy to semen", which is the most important POIS paper that I know of because this is the first POIS study to use a control group. Jiang (2015) showed that healthy (non-POIS) males also have semen IgE and positive skin prick allergy test. This validated Attia's (2011) reply to Waldinger, namely that semen allergy is a common and separate disease from POIS. People need to know that you can have more that one disease, and one disease does not necessarily cause another.

  After Attia, et al. (2013) and Jiang, et al. (2015), Waldinger revised his original hypothesis to exclude Type I IgE allergy from his description of POIS (Waldinger, 2016):
"POIS is not associated with increased total serum IgE concentrations." -Post orgasmic illness syndrome (MD Waldinger, 2016)

  Finally, the study "Immunophenotypical Characterization of a Brazilian POIS (Post-Orgasmic Illness Syndrome) Patient: Adding More Pieces to Puzzle" by Amicis et al. (2019) used a control group to show that men with POIS and men without POIS have similar clinical reations to dilute semen skin prick test and subcutaneous semen injections. The POIS patient did not have elevated semen IgE, but two of the non-POIS healthy controls did have elevated semen IgE. So semen allergy was shown to be a separate disease from POIS. Also, both Amicis et al. (2019) and Kim et al. (2018) showed that hypodesensitization therapy (autologous semen injections) failed to produce lasting reductions of POIS symptoms. Amicis et al. (2019) did find elevated IgG in the semen of the POIS patient. And medical test from POISers on this forum do not confirm any correlation between POIS and semen allergy:
  MCAS test
--8 of us show normal trypase (mast cell activation syndrome) levels (itsmel, BluesBrother, nanna1, Vandemolen, Muon, Muon's brother, jakov, Simon66).
--11 of us show normal IgE (allergy) levels (BlueBrother, aswinpras06, certainlypois2, Vandemolen, kurtosis, rjmlr, Yin POIS Study, jakov, Depreux POIS study, kingfisher, Arata POIS study)
--3 of us show normal histamine levels (nanna1 tested histamine, itsmel and Muon tested histamine and N-methyl-histamine).
--1 of us show low histamine levels (Simon66, tested histamine and N-methyl-histamine)
--1 of us show normal PGD2 levels (muon).

   Autoimmunity test
--5 of us have normal autoimmune panel test (nanna1, quotz, Vandemolen, muon, Arata POIS study).
--1 of us show possible autoimmunity (Iwillbeatthis), correlated with positive EBV (HHV-4) infection
--1 of us show normal/negative autoimmune antibody test for onconeural antibodies, insulin, peripheral NMDA-receptor, adrenal-cortex, potassium channel, glutamic acid decarboxylase (Muon's brother)

  Inflammation
--3 show normal C reactive protein (CRP) (kingfisher, certainlypois2, BluesBrother, Simon66)
--1 reports high CRP (IronFeather)
--3 show normal ESR (Simon66, nanna1, certainlypois2)
--1 complement system activity (C3a, C4) normal (BluesBrother)

  I think that the semen allergy hypothesis has been thoroughly studied and discredited. I suspect that men (both POISers and non-POISers) with elevated immunoglobins (IgE or IgG) in their semen have sexually transmitted diseases. This is my personal hypothesis: viruses and bacteria that enter the seminal fluid can also stimulate immune cells to produce IgE/IgG antibodies against those pathogens so that they do not infect the female or kill the sperm. Injecting those viruses or bacteria (and their IgE/IgG antibodies) back into the body is probably not a good idea. I hope this helps. :)

« Last Edit: September 26, 2020, 10:39:18 PM by nanna1 »
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Clues

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #8 on: September 25, 2020, 01:37:22 AM »
nanna1, thanks for the detailed summary!
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nanna1

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Re: Allergy hypothesis for people with mainly cognitive problems
« Reply #9 on: September 26, 2020, 10:04:47 PM »
No problem Clues!
POIS clusters: 1,3,4,5,7
POIS criteria: 1,2,3,4,5
2 stacks that give me complete relief of POIS symptoms are listed here: POIS cure: theory & supplement stack
Find medical test: https://www.findlabtest.com/